Dual-response for Hg<sup>2+</sup> and Ag<sup>+</sup> ions based on biomimetic funnel-shaped alumina nanochannels

Wang, Huimin; Hou, Shengnan; Wang, Qinqin; Wang, Zhiwei; Fan, Xia; Zhai, Jin

doi:10.1039/c4tb01804d

Cited by 40 publications

(33 citation statements)

References 60 publications

(69 reference statements)

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“…For example, appropriate determination of

I - V

response of a PE‐brush grafted nanochannel in presence and in absence of an external ionic species allows sensing of that particular species (e.g. L‐tryptophan , DNA oligomer , hydrogen peroxide , enantiomers , cysteine ,

H g^{2 +} i o n s

A g^{+}

ions , etc.). Very often such a response can be pH‐sensitive , given that this particular chemical moiety may have a pH‐sensitive ionization.…”

Section: Discussionmentioning

confidence: 99%

“…L‐tryptophan , DNA oligomer , hydrogen peroxide , enantiomers , cysteine ,

H g^{2 +} i o n s

A g^{+}

ions , etc.). Very often such a response can be pH‐sensitive , given that this particular chemical moiety may have a pH‐sensitive ionization. Therefore, having a theoretical foundation for quantifying the pH‐responsive ionic current in a PE‐grafted nanochannel in a manner such that the specifics of the PE configuration is also accounted for in the ionic current calculation is central for designing a PE‐grafted nanochannel as an efficient bioanalyte and ion sensing device.…”

Section: Discussionmentioning

confidence: 99%

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Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Chen

Das

2017

Electrophoresis

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In this paper, we study the thermodynamics, electrostatics, and an external electric field driven ionic current in a pH-responsive, end-charged polyelectrolyte (PE) brush grafted nanochannel. By employing a mean field theory, we unravel a highly nonintuitive interplay of pH and electrolyte salt concentration in dictating the height of the end-charged PE brush. Larger pH or weak hydrogen ion concentration leads to maximum ionization of the charge-producing group-as a consequence, the resulting the electric double layer (EDL) energy get maximized causing a maximum deviation of the brush height from the value (d ) of the uncharged brush. This deviation may result in enhancement or lowering of the brush height as compared to d depending on whether the PE end locates lower or higher than h/2 (h is the nanochannel half height) and the salt concentration. Subsequently, we use this combined PE-brush-configuration-EDL-electrostatics framework to compute the ionic current in the nanochannel. We witness that the ionic current for smaller pH is much larger despite the corresponding magnitude of the EDL electrostatic potential being much smaller-this stems from the presence of a much larger concentration of H+ ions at small pH and the fact that H+ ions have very large mobilities. In fact, this ionic current shows a steep variation with pH that can be useful in exploring new designs for applications involving quantification and characterization of ionic current in PE-brush-grafted nanochannels.

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“…For example, appropriate determination of

I - V

H g^{2 +} i o n s

A g^{+}

ions , etc.). Very often such a response can be pH‐sensitive , given that this particular chemical moiety may have a pH‐sensitive ionization.…”

Section: Discussionmentioning

confidence: 99%

“…L‐tryptophan , DNA oligomer , hydrogen peroxide , enantiomers , cysteine ,

H g^{2 +} i o n s

A g^{+}

Section: Discussionmentioning

confidence: 99%

Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Chen

Das

2017

Electrophoresis

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“…Such a great property is very useful for building a 4 highly sensitive and specific biosensor. Therefore, it is desirable to develop the nanochannel-based biosensor for high sensitive and specific detection of biomolecules (Sun et al, 2014;Liu et al, 2015;Sun et al, 2015;Gao et al, 2015;Wang et al, 2015;Sun et al, 2012;Xu et al, 2015;.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Sun

Liao

Zhang

et al. 2016

Biosensors and Bioelectronics

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“…The same principle was later utilized for the simultaneous responsiveness to Ag + and Hg 2+ in funnel‐shaped alumina nanochannels covalently modified with ssDNA, taking advantage of the specific interaction between Hg 2+ ions and T bases as well as Ag + ions and C bases . By varying the pH of the solution, Hg 2+ and Ag + ions could be sensed individually.…”

Section: Rational Integration Of (Bio)molecular Architectures Into Namentioning

confidence: 99%

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

et al. 2019

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Solid‐state nanopores are fascinating objects that enable the development of specific and efficient chemical and biological sensors, as well as the investigation of the physicochemical principles ruling the behavior of biological channels. The great variety of biological nanopores that nature provides regulates not only the most critical processes in the human body, including neuronal communication and sensory perception, but also the most important bioenergetic process on earth: photosynthesis. This makes them an exhaustless source of inspiration toward the development of more efficient, selective, and sophisticated nanopore‐based nanofluidic devices. The key point responsible for the vibrant and exciting advance of solid nanopore research in the last decade has been the simultaneous combination of advanced fabrication nanotechnologies to tailor the size, geometry, and application of novel and creative approaches to confer the nanopore surface specific functionalities and responsiveness. Here, the state of the art is described in the following critical areas: i) theory, ii) nanofabrication techniques, iii) (bio)chemical functionalization, iv) construction of nanofluidic actuators, v) nanopore (bio)sensors, and vi) commercial aspects. The plethora of potential applications once envisioned for solid‐state nanochannels is progressively and quickly materializing into new technologies that hold promise to revolutionize the everyday life.

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Dual-response for Hg²⁺ and Ag⁺ ions based on biomimetic funnel-shaped alumina nanochannels

Abstract: DNA modified funnel-shaped alumina nanochannels have been fabricated, which could sense Hg2+ and Ag+ ions with good selectivity and sensitivity.

Cited by 40 publications

References 60 publications

Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

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Dual-response for Hg2+ and Ag+ ions based on biomimetic funnel-shaped alumina nanochannels

Abstract: DNA modified funnel-shaped alumina nanochannels have been fabricated, which could sense Hg2+ and Ag+ ions with good selectivity and sensitivity.

Cited by 40 publications

References 60 publications

Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Thermodynamics, electrostatics, and ionic current in nanochannels grafted with pH‐responsive end‐charged polyelectrolyte brushes

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

Contact Info

Product

Resources

About

Dual-response for Hg²⁺ and Ag⁺ ions based on biomimetic funnel-shaped alumina nanochannels