Dual-response nanocarrier based on graft copolymers with hydrazone bond linkages for improved drug delivery

He, Yueying; Zhang, Yan; Xiao, Yan; Lang, Meidong

doi:10.1016/j.colsurfb.2010.05.038

Cited by 43 publications

(19 citation statements)

References 37 publications

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“…This was demonstrated by Lang et al, who utilized the hydrazone bond to prepare pH/Temperature dual responsive polymer brushes [72]. It is known that hydrazone bonds are stable at physiological pH (7.0-7.4) but cleavable at the low pH levels (5.0-5.5).…”

Section: Thermo and Ph Dually Responsive Molecular Brushesmentioning

confidence: 93%

When dual and multi-responsiveness meet molecular brushes

Guo

Peng

Yuan

2015

European Polymer Journal

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Section: Thermo and Ph Dually Responsive Molecular Brushesmentioning

confidence: 93%

When dual and multi-responsiveness meet molecular brushes

Guo

Peng

Yuan

2015

European Polymer Journal

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“…The diameters of spheres observed by TEM were slightly smaller than those by DLS ( Figure 5). The reason for this difference was that the mean diameters determined by DLS represented their hydrodynamic diameters after the hydration of mPEG segments, whereas those determined by TEM reflected the dried micelles [36,37].…”

Section: Characterization Of Empty and Dox Loaded Micellesmentioning

confidence: 99%

Novel PLGGE graft polymeric micelles for doxorubicin delivery

Sheng

et al. 2012

Chin. Sci. Bull.

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Novel poly{(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-g-monomethyl poly(ethylene glycol) (PLGGE) micelles were prepared and used as carriers for anti-tumor drug delivery. Three PEGylated PLGG copolymers (PLGGE2000, PLGGE1100 and PLGGE500) were characterized by XRD, TG and DSC. The critical micelle concentrations (CMCs) of the amphiphilic copolymers were 1.04, 0.55 and 0.13 μg/mL, respectively. The TEM, AFM and DLS measurements revealed that the micelles were homogeneous spherical nanoparticles with the diameters ranged from 50 to 150 nm when THF was used as solvent in the preparation of the micelles. Interestingly, extended cylindrical micelles were obtained using CHCl 3 as solvent. The micelles could trap doxorubicin (DOX) in the core with the highest drug loading content up to 23.7%. The mean diameter of drug loaded micelles was much bigger than that of blank micelles. The in vitro drug release of the micelles was diffusion-controlled release within the first 36 h and initial burst release was not obvious. However, after 36 h, the release rate in pH 5.0 was faster than that in pH 7.4 due to the degradation. The PLGGE micelles were nontoxic to both NIH 3T3 fibroblasts and HepG2 cells. The in vitro cytotoxicity against HepG2 cells demonstrated that the drug loaded micelles exhibited high inhibition activity to cancer cells. CLSM observation of HepG2 cells showed that DOX released from the micelles could be delivered into cell cytoplasm and cell nuclei. PLGGE micelles are potential promising carriers for anti-tumor drug delivery. PLGGE, micelles, drug delivery, doxorubicin Citation:Yu Z X, He B, Sheng M M, et al. Novel PLGGE graft polymeric micelles for doxorubicin delivery.

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“…Poly( N ‐isopropyl acrylamide) [poly(NIPAAm)] is a widely investigated thermoresponsive polymer, which shows a lower critical solution temperature (LCST) around 32 °C in aqueous media . PNIPAAm is water soluble below 32 °C, and above this, the polymer becomes water insoluble, and the system approaches macroscopic phase separation .…”

Section: Introductionmentioning

confidence: 99%

Vesicular and micellar self‐assembly of stimuli‐responsive poly(N‐isopropyl acrylamide‐b‐9‐anthracene methyl methacrylate) amphiphilic diblock copolymers

Pawar

Kutcherlapati

Yeole

et al. 2018

J of Applied Polymer Sci

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Dually responsive amphiphilic diblock copolymers consisting of hydrophilic poly(N‐isopropyl acrylamide) [poly(NIPAAm)] and hydrophobic poly(9‐anthracene methyl methacrylate) were synthesized by reversible addition fragmentation chain‐transfer (RAFT) polymerization with 3‐(benzyl sulfanyl thiocarbonyl sulfanyl) propionic acid as a chain‐transfer agent. In the first step, the poly(NIPAAm) chain was grown to make a macro‐RAFT agent, and in the second step, the chain was extended by hydrophobic 9‐anthryl methyl methacrylate to yield amphiphilic poly(N‐isopropyl acrylamide‐b‐9‐anthracene methyl methacrylate) block copolymers. The formation of copolymers with three different hydrophobic block lengths and a fixed hydrophilic block was confirmed from their molecular weights. The self‐assembly of these copolymers was studied through the determination of the lower critical solution temperature and critical micelle concentration of the copolymers in aqueous solution. The self‐assembled block copolymers displayed vesicular morphology in the case of the small hydrophobic chain, but the morphology gradually turned into a micellar type when the hydrophobic chain length was increased. The variations in the length and chemical composition of the blocks allowed the tuning of the block copolymer responsiveness toward both the pH and temperature. The resulting self‐assembled structures underwent thermally induced and pH‐induced morphological transitions from vesicles to micelles and vice versa in aqueous solution. These dually responsive amphiphilic diblock copolymers have potential applications in the encapsulation of both hydrophobic and hydrophilic drug molecules, as evidenced from the dye encapsulation studies. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46474.

show abstract

Dual-response nanocarrier based on graft copolymers with hydrazone bond linkages for improved drug delivery

Cited by 43 publications

References 37 publications

When dual and multi-responsiveness meet molecular brushes

When dual and multi-responsiveness meet molecular brushes

Novel PLGGE graft polymeric micelles for doxorubicin delivery

Vesicular and micellar self‐assembly of stimuli‐responsive poly(N‐isopropyl acrylamide‐b‐9‐anthracene methyl methacrylate) amphiphilic diblock copolymers

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