Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery

Yadavalli, Tejabhiram; Ramasamy, Shivaraman; Gopalakrishnan, C.; Michael, Isaac; Therese, Helen Annal; Chennakesavulu, Ramasamy

doi:10.1016/j.jmmm.2014.09.035

Cited by 86 publications

(35 citation statements)

References 16 publications

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“…As the nanoparticles typically span in the size range of 10–500 nm, their interactions with mammalian cells can be programmed based on the particle size and functional requirement. In addition to more conventional polymeric nanoparticles, metal and metal oxide nanoparticles can also play a major role in detection [2], and external control over drug delivery [3]. Over the past two decades, various nanoparticles and drug delivery models have been designed and implemented to treat cancers [3–4], offset diabetes [5], control bacterial infections via antimicrobial coatings [6], cross the blood brain barrier [7], and form vaccines [8].…”

Section: Introductionmentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

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156

111

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Nanotechnology is increasingly playing important roles in various fields including virology. The emerging use of metal or metal oxide nanoparticles in virus targeting formulations shows the promise of improved diagnostic or therapeutic ability of the agents while uniquely enhancing the prospects of targeted drug delivery. Although a number of nanoparticles varying in composition, size, shape, and surface properties have been approved for human use, the candidates being tested or approved for clinical diagnosis and treatment of viral infections are relatively less in number. Challenges remain in this domain due to a lack of essential knowledge regarding the in vivo comportment of nanoparticles during viral infections. This review provides a broad overview of recent advances in diagnostic, prophylactic and therapeutic applications of metal and metal oxide nanoparticles in Human Immunodeficiency Virus, Hepatitis virus, influenza virus and Herpes virus infections. Types of nanoparticles commonly used and their broad applications have been explained in this review.

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Section: Introductionmentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

Self Cite

156

111

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“…Stimuli-responsive polymeric nanogels are cross-linked structures of colloidal particles in nanometer sizes, which can contract and expand in response to changes in the external environment, such as temperature, pH, or ionic strength [1][2][3]. Due to their exceptional features and extensive scope of applicability, these materials have drawn considerable attention over recent decades [2].…”

Section: Introductionmentioning

confidence: 99%

“…The thermoresponsive polymer known as poly-N-isopropylacrylamide (PNIPAm) is among the most widely researched stimuli-responsive polymers. The applications of PNIPAm are mainly related to the areas of drug delivery [3][4][5] and the immobilization as well as adsorption of enzymes and proteins [6]. This is partially due to inherent physical properties, which are modulated by the reversible phase separation behavior.…”

Section: Introductionmentioning

confidence: 99%

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Khan

El‐Toni

Alam

et al. 2018

Journal of Nanomaterials

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Herein, we report a simple and easy procedure for the synthesis of core-shell structures of glucose-sensitive 3-acrylamidophenylboronic acid (APBA) and temperature-responsive P(NIPAm-AAc) shell nanogel particles using MBA as a cross-linker via free radical polymerization. The synthesized particles were approximately 100 nm and were cross-linked to one another. The shell thickness of the nanogel particles was adjusted by increasing the concentrations of NIPAm through the semibath approach during the process of polymerization. The synthesized colloidal nanogel particle shows thermoresponsive behaviors. The dynamic light scattering technique also confirmed the change in the size of particles dispersed in an aqueous solution upon increase/decrease in temperatures, which is the result of its volume phase transition temperatures (VPTT). The size and morphology of the particles were characterized by TEM, FE-SEM, and AFM. The sensitivity of these nanogel particles to temperature and glucose suggests that they have the potential for applications related to the delivery of self-regulated insulin.

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“…Thermoresponsive polymers, especially poly(N-isopropylacrylamide) (PNIPAM) and its copolymers are investigated with great interest for their applications in biomedical fields [1][2][3][4][5]. These polymers in aqueous solution show a typical coil-to-globule transition above its lower critical solution temperature (LCST), that is upon heating the water soluble extended chains of the polymer collapse to form compact insoluble globules [6,7].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

Jadhav¹,

Scalarone²,

Brunella³

et al. 2017

Express Polym. Lett.

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Abstract.A series of poly(N-isopropylacrylamide-co-acrylamide) thermoresponsive random copolymers with different molecular weights and composition were synthesized and characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), differential scanning calorimetry (DSC), size exclusion chromatography (SEC) and proton nuclear magnetic resonance (NMR) spectroscopy. The lower critical solution temperatures (LCST) of the copolymers were tuned by changing the mole ratios of monomers. Copolymer with highest molecular weight and LCST (41.2°C) was grafted on SBA-15 type mesoporous silica particles by a two-step polymer grafting procedure. Bare SBA-15 and the thermoresponsive copolymergrafted (hybrid) SBA-15 particles were fully characterized by scanning electron microscope (SEM), ATR-FTIR, thermogravimetric analysis (TGA) and Brunauer-Emmett-Teller (BET) analyses. The hybrid particles were tested for their efficiency as temperature-sensitive systems for dermal delivery of the antioxidant rutin (quercetin-3-O-rutinoside). Improved control over rutin release by hybrid particles was obtained which makes them attractive hybrid materials for drug delivery.

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Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery

Cited by 86 publications

References 16 publications

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Semibath Polymerization Approach for One-Pot Synthesis of Temperature- and Glucose-Responsive Core-Shell Nanogel Particles

Thermoresponsive copolymer-grafted SBA-15 porous silica particles for temperature-triggered topical delivery systems

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