2015
DOI: 10.4049/jimmunol.194.supp.185.5
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Dual roles of GM-CSF in modulating NK-cell migratory properties (CAM4P.147)

Abstract: Background: Natural Killer (NK) cells play a key role in innate immunity against viral, microbial infections and transformed cells and their migration for effector function to peripheral tissues or inflamed lymph nodes are tightly regulated. Of interest, production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by cancer cells is correlated to host immune suppression and tumor metastasis, suggesting an immune evasion property of GM-CSF. Here we examined role(s) of recombinant GM-CSF in the regula… Show more

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