2022
DOI: 10.3892/ijmm.2022.5189
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Dual roles of oxostephanine as an Aurora kinase inhibitor and angiogenesis suppressor

Abstract: The Aurora kinases, including Aurora A, B and c, play critical roles in cell division. They have been found overexpressed in a number of types of cancer and may thus be potential targets in cancer therapy. Several Aurora kinase inhibitors have been identified and developed. Some of these have been used in clinical trials and have exhibited certain efficacy in cancer treatment. However, none of these has yet been applied clinically due to the poor outcomes. Oxostephanine is an aporphine alkaloid isolated from s… Show more

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Cited by 5 publications
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“…The study conducted by Tran et al (2022) . extracted oxostephanine from the leaves of Stephania dielsiana Y.C.Wu., and demonstrated its potential as an aurora kinase inhibitor.…”
Section: Resultsmentioning
confidence: 99%
“…The study conducted by Tran et al (2022) . extracted oxostephanine from the leaves of Stephania dielsiana Y.C.Wu., and demonstrated its potential as an aurora kinase inhibitor.…”
Section: Resultsmentioning
confidence: 99%