Dual-Sensitive Graphene Oxide Loaded with Proapoptotic Peptides and Anticancer Drugs for Cancer Synergetic Therapy

Zhang, Jing; Chen, Liqun; Shen, Biao; Chen, Lingdong; Mo, Jiaying; Feng, Jie

doi:10.1021/acs.langmuir.9b00611

Cited by 34 publications

(31 citation statements)

References 59 publications

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“…The GO carrier was coated by bovine serum albumin (BSA) and the DOX@GO-SS-KLA/BSA DDS, which was stable in biological media, was prepared. The results showed that the reduction and pH inside the cells, respectively, caused the release of KLA and DOX, and synergy was achieved [154].…”

Section: Figure 11mentioning

confidence: 98%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Figure 11mentioning

confidence: 98%

Graphenic Materials for Biomedical Applications

2019

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“…That the improvement of drug efficacy was achieved by the loading of GO that has a low toxicity has been reported [37]. Zhang et al [38] confirmed that the GO-loaded pro-apoptotic polypeptide drug delivery system effectively inhibit the proliferation of cancer cells. Similar results were reported in this study that AWRK6/GO was more efficient and effective with regard to the amelioration of the survival time and survival rate of LPS mice than AWRK6.…”

Section: Discussionmentioning

confidence: 75%

Efficacy of graphene oxide-loaded cationic antimicrobial peptide AWRK6 on the neutralization of endotoxin activity and in the treatment of sepsis

Song

Zhao

Yang

et al. 2021

Aging

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Objective: This study is to assess the therapeutic effect of graphene oxide (GO) loaded with AWRK6 on endotoxininduced sepsis. Method: AWRK6/GO was prepared by GO loaded AWRK6, with the structure characterization of AWRK6/GO conducted by atomic force microscope (AFM) and ultraviolet spectrophotometer, the sustained release rate of AWRK6/GO detected by high performance liquid chromatography (HPLC), and the neutralization ability of AWRK6/GO to lipopolysaccharide (LPS) tested by in vitro experiments. The levels of IL-8 and TNF-α in mouse cells after drug intervention were detected by ELISA; a LPS mouse model was established to observe the effects of drug intervention on the survival cycle and survival rate of mice. Results: The sustained drug release rate of AWRK6/GO reached 85% within 24 hours observed under in vitro conditions, with an efficient neutralization effect to LPS (P < 0.01); Compared with the control group, the intervention of LPS succeeded in remarkably elevating the levels of IL-8 and TNF-α in the whole blood and macrophages of the mice (P < 0.01), whose survival cycle and survival rate consequently observed an obvious decline (P < 0.01); The intervention with AWRK6 or AWRK6/GO predominantly brought down the levels of IL-8 and TNF-α in the whole blood and macrophages of mice given LPS (P < 0.01), resulting in an elevation of the survival rate and survival time (P < 0.01). Conclusion: GO loaded with cationic antimicrobial peptide AWRK6 exerts a rosy neutralization effect on endotoxin activity, with no obvious side effects on mice observed, which is of certain application value in the treatment of sepsis.

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“…As the simultaneous loading of several drugs with different mechanisms of action on the same nanocarrier, obtaining a nanocarrier sensitive to double/multiple endogenous stimuli is also a way to increase therapeutic efficacy. Recently, Zhang J. et al (2019) designed and constructed a dual-sensitive cancer combination treatment system utilizing GO to load proapoptotic peptide (KLA) and anticancer drugs. The proapoptotic peptide is an amino acid sequence of lysine (K), leucine (L), and alanine (A), (KLAKLAK) 2 , that can induce mitochondrial-dependent apoptosis while remaining relatively non-toxic extracellularly.…”

Section: Drug Delivery Application In Cancer Therapymentioning

confidence: 99%

Methods to Scale Down Graphene Oxide Size and Size Implication in Anti-cancer Applications

Tufano

Vecchione

Netti

2020

Front. Bioeng. Biotechnol.

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Despite considerable progress in the comprehension of the mechanisms involved in the origin and development of cancer, with improved diagnosis and treatment, this disease remains a major public health challenge with a considerable impact on the social and economic system, as well as on the individual. One way to improve effectiveness and reduce side effects is to consider responsive stimuli delivery systems that provide tailor-made release profiles with excellent spatial and temporal control. 2D nanomaterials possess special physicochemical properties (e.g., light, ultrasonic and magnetic responses) and biological behaviors such as endocytosis, biodistribution, biodegradation, and excretory pathways, which lead to their use in various biomedical applications. In particular, among 2D nanomaterials, graphene and its derivatives, namely graphene oxide (GO) nanomaterials, have attracted enormous attention in cancer diagnosis and therapy because they combine, in a unique material, extremely small size, NIR absorption, delocalized electrons, extremely high surface area, and versatile surface functionality. Taking into account the fundamental role played by GO size, in this review, we summarize the main methods employed to reduce and homogenize in nanometric scale the lateral dimensions of graphene oxide produced by chemical exfoliation of graphite, as well as post-synthesis separation techniques to uniform the size. We also discuss the implication of the small size in cancer treatment by exploiting GO nanocarriers as an effective theranostic tool.

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Dual-Sensitive Graphene Oxide Loaded with Proapoptotic Peptides and Anticancer Drugs for Cancer Synergetic Therapy

Cited by 34 publications

References 59 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Efficacy of graphene oxide-loaded cationic antimicrobial peptide AWRK6 on the neutralization of endotoxin activity and in the treatment of sepsis

Methods to Scale Down Graphene Oxide Size and Size Implication in Anti-cancer Applications

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