Dual Sensory Impairment and Cognitive Decline: The Results From the Shelter Study

Yamada, Yukari; Denkinger, Michael; Onder, Graziano; Henrard, Jean-Claude; Roest, Henriëtte van der; Finne-Soveri, Harriet; Richter, Tomáš; Vlachova, Martina; Bernabei, Roberto; Topinková, Eva

doi:10.1093/gerona/glv036

Cited by 90 publications

(74 citation statements)

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“…Sensory loss is associated with an array of detrimental clinical and functional outcomes, depending on the sense involved . Evidence supporting such relationships has focused primarily on single‐sensory modalities or dual impairments (typically vision and hearing), and dual deficits have ben found to have synergistic detrimental effects …”

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confidence: 99%

Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults

Pinto

Wroblewski

Huisingh-Scheetz

et al. 2017

J American Geriatrics Society

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OBJECTIVES:To evaluate global sensory impairment (GSI, an integrated measure of sensory dysfunction) as a predictor of physical function, cognition, overall health, and mortality. DESIGN: Prospective study. SETTING: The National Social Life, Health, and Aging Project. PARTICIPANTS: A national probability sample of 3,005 home-dwelling older U.S. adults assessed at baseline and 5-year follow-up (2010-11). MEASUREMENTS: Gait speed, activity, disability, cognition, overall health, 5-year mortality. RESULTS: At baseline, older adults with worse GSI were slower (Timed Up and Go times: odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.17-1.50) and had more activity of daily living deficits (≥2: OR = 1.26, 95% CI = 1.10-1.46). Five years later, they were still slower (timed walk: OR = 1.22, 95% CI = 1.05-1.42), had more disabilities (≥2 instrumental activities of daily living; OR = 1.45, 95% CI = 1.23-1.70), were less active (daytime activity according to accelerometry: b = À2.7, 95% CI = À5.2 to À0.2), had worse cognitive function (Montreal Cognitive Assessment; b = À0.64, 95% CI = À0.84 to À0.44), more likely to have poorer overall health (OR = 1.16, 95% CI = 1.03-1.31) and lose weight (>10%: OR = 1.31, 95% CI = 1.04-1.64), and have died (OR = 1.45, 95% CI = 1.19-1.76). All analyses were adjusted for relevant confounders at baseline, including age, sex, race and ethnicity, education, smoking, problem drinking, body mass index, comorbidities, and cognitive function. CONCLUSION: GSI predicts impaired physical function, cognitive dysfunction, significant weight loss, and mortality 5 years later in older U.S. adults. Multisensory evaluation may identify vulnerable individuals, offering the opportunity for early intervention to mitigate adverse outcomes.

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confidence: 99%

Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults

Pinto

Wroblewski

Huisingh-Scheetz

et al. 2017

J American Geriatrics Society

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“…Nursing home residents with dual sensory impairment (i.e., of concurrent vision and hearing) have a greater cognitive decline over time compared to those without sensory impairment (Yamada et al 2016). The primary auditory cortex (A1) is dynamically regulated by the neurotransmitter ACh; the regulatory mechanism modulated by ACh has been shown to integrate sensory information processing in A1 neurons (Metherate 2011).…”

Section: Sensory Impairment: Multiple Risk Factors Sensory Decline Inmentioning

confidence: 99%

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Daulatzai

2016

Neurotox Res

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Sporadic Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is essential to unravel its etiology and pathogenesis. This should enable us to study the presymptomatic stages of the disease and to analyze and reverse the antemortem behavioral, memory, and cognitive dysfunction. Prima facie, an ongoing chronic vulnerability involving neural insult may lead normal elderly to mild cognitive impairment (MCI) and then to AD. Development of effective preventive and therapeutic strategies to thwart the disease pathology obviously requires a thorough delineation of underlying disruptive neuropathological processes. Our sensory capacity for touch, smell, taste, hearing, and vision declines with advancing age. Declines in different sensory attributes are considered here to be the primary "first-tier pathologies." Olfactory loss is among the first clinical signs of neurodegenerative diseases including AD and Parkinson's disease (PD). Sensory dysfunction in the aged promotes pathological disturbances in the locus coeruleus, basal forebrain, entorhinal cortex, hippocampus, and several key areas of neocortex and brainstem. Hence, sensory dysfunction is the pivotal factor that may upregulate cognitive and memory dysfunction. The age-related constellation of comorbid pathological factors may include apolipoprotein E (APOE) genotype, obesity, diabetes, hypertension, alcohol abuse, head trauma, and obstructive sleep apnea. The concepts and trajectories delineated here are the dynamic pillars of the current hypothesis presented-it postulates that the sensory decline, in conjunction with the above pathologies, is crucial in triggering neurodegeneration and promoting cognitive/memory dysfunction in aging and AD. The application of this thesis can be important in formulating new multifactorial preventive and treatment strategies (suggested here) in order to attenuate cognitive and memory decline and ameliorate pathological dysfunction in aging, MCI, and AD.

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“…In particular, the risks of worsening functional and cognitive abilities, social isolation, 6,7 falls 8 and sensory impairment should be highlighted. 7 The services provided by LSIEs must be sensitive to the needs of the elderly in order to reduce the risks associated with institutionalization, thereby providing comfort, security, and quality of life and preserving independence. Thus, this study aims to characterize long-term institutions for the elderly regarding physical-structural and organizational aspects.…”

Section: Introductionmentioning

confidence: 99%

“…17 Consequently, there may be little interaction among residents, excessive idle time, or only their involvement in passive activities. 7 A study on the sensory and cognitive decline of 4156 elderly people living in nursing homes in eight European countries reported that factors such as hearing and visual impairment are directly associated with functional decline. This decline is higher in elderly people who present social isolation, resulting not only from a lack of interaction with other residents, but also from a lack of activities such as reading, listening to the radio, and watching television.…”

mentioning

confidence: 99%

“…This decline is higher in elderly people who present social isolation, resulting not only from a lack of interaction with other residents, but also from a lack of activities such as reading, listening to the radio, and watching television. 7 Hence, the importance of developing diversified activities is emphasized with an expanded multi-professional team including professionals such as a physical educator and the existence of spaces that encourage the elderly to leave their beds to interact with other residents.…”

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confidence: 99%

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Long-stay institutions for the elderly: physical-structural and organizational aspects

et al. 2017

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Objective: To characterize long-stay institutions for the elderly in respect to physical-structural and organizational aspects.Method: This descriptive, cross-sectional, quantitative research was carried out in four long-stay institutions for the elderly in Salvador -Bahia, Brazil, between September and November 2013. Data were collected from the technical officers of the institutions using a questionnaire based on National Health Surveillance Agency standards. Results: This study highlights a partial compliance with current regulations both in respect to the physical-structural and organizational aspects. The elderly are exposed to an environment that is sometimes unhealthy with risk factors for health problems. Conclusion and implications for practice: There is need for adjustments in the institutions to comply with current legislation. This study shows the importance of a multidisciplinary team to provide comprehensive care of institutionalized elderly, with emphasis on the role of nurses in the qualification of institutions and valorization of the elderly. Evidencia-se um atendimento parcial à regulamentação vigente tanto nos aspectos físico-estruturais quanto organizacionais. Os idosos são expostos a um ambiente, por vezes, insalubre e a fatores de riscos para agravos à saúde. Conclusão e implicações para a prática: Há necessidade de ajustes nas instituições para o atendimento à legislação vigente. Defende-se a importância de uma equipe multiprofissional para o cuidado integral às pessoas idosas institucionalizadas, com ênfase no papel da enfermagem para a qualificação das instituições e valorização dos idosos.Palavras-chave: Idoso; Instituição de Longa Permanência para Idosos; Saúde do idoso; Estrutura dos serviços. resumenObjetivo: Caracterizar instituciones de larga estadía para los ancianos como los aspectos físicos estructurales y organizativas.Método: Transversal, la investigación cuantitativa descriptiva, llevado a cabo en cuatro instituciones de larga estadía para las personas mayores de Salvador -Bahia, Brasil, entre septiembre y noviembre de 2013. Los datos fueron recogidos entre los responsables técnicos de las instituciones a través de un cuestionario basado en estándares Agencia Nacional de Vigilancia Sanitaria. Resultados: Este estudio pone de manifiesto un cumplimiento parcial de la normativa vigente, tanto en los aspectos físicos y estructurales como de organización. Los ancianos están expuestos a un ambiente a veces factores insalubres y de riesgo de problemas de salud. Conclusión e implicaciones para la práctica: Existe la necesidad de ajustes en las instituciones para el cumplimiento de la legislación vigente. Aboga por la importancia de un equipo multidisciplinario para la atención integral a las personas mayores institucionalizadas, con énfasis en el papel de la enfermería para la calificación de las instituciones y la apreciación de las personas mayores.Palabras clave: Anciano; Hogares para ancianos; Salud del anciano; Estructura de los servicios. EEAN.edu.br 2

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Dual Sensory Impairment and Cognitive Decline: The Results From the Shelter Study

Abstract: Cognitive function declines faster in nursing home residents with DSI only when residents were not socially engaged. Therefore, residents with DSI might cognitively benefit from interventions to improve involvement in social life at nursing homes.

Cited by 90 publications

References 44 publications

Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults

Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Long-stay institutions for the elderly: physical-structural and organizational aspects

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