Dual-source powered nanomotors coupled with dual-targeting ligands for efficient capture and detection of CTCs in whole blood and in vivo tumor imaging

Ren, Jiaoyu; Chen, Zekun; Ma, Enhui; Wang, Wenjun; Zheng, Shaohui; Wang, Hong

doi:10.1016/j.colsurfb.2023.113568

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…The modification of folic acid (FA) and hyaluronic acid (HA) carbon dots endowed the nanomotor with target recognition ability. This nanomotor showed the ability to capture specific circulating tumor cells, provide imaging (fluorescence from carbon dots), and achieve quantitative detection due to the modification of the recognition elements (FA and HA), thus providing a new possibility for cancer detection [ 122 ].…”

Section: Dual-propelled Nano/micromotorsmentioning

confidence: 99%

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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Nano/micromotors are artificial robots at the nano/microscale that are capable of transforming energy into mechanical movement. In cancer diagnosis or therapy, such “tiny robots” show great promise for targeted drug delivery, cell removal/killing, and even related biomarker sensing. Yet biocompatibility is still the most critical challenge that restricts such techniques from transitioning from the laboratory to clinical applications. In this review, we emphasize the biocompatibility aspect of nano/micromotors to show the great efforts made by researchers to promote their clinical application, mainly including non-toxic fuel propulsion (inorganic catalysts, enzyme, etc.), bio-hybrid designs, ultrasound propulsion, light-triggered propulsion, magnetic propulsion, dual propulsion, and, in particular, the cooperative swarm-based strategy for increasing therapeutic effects. Future challenges in translating nano/micromotors into real applications and the potential directions for increasing biocompatibility are also described.

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Section: Dual-propelled Nano/micromotorsmentioning

confidence: 99%

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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“…This overexpression can be utilized to attach a large amount of modified nanoparticles to obtain the desired effect, which will have a minimum impact on normal blood or tissue cells [ 21 , 22 ]. Ren et al used folic acid- and hyaluronic acid-modified carbon dot-coated magnetic nanoparticles (CD@NMs) with the overexpressed folate receptor on tumor cells and the self-propulsion of CD@NMs under the drive of a magnetic field and H 2 O 2 , CD@NMs can efficiently and sensitively capture CTCs [ 23 ]. Bio-affinity capture methods are very effective isolation methods but can be combined with physical methods to increase capture efficiency.…”

Section: Introductionmentioning

confidence: 99%

Design and Application of Microfluidic Capture Device for Physical–Magnetic Isolation of MCF-7 Circulating Tumor Cells

Bendre,

Somasekhara,

Nadumane

et al. 2024

Biosensors

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Circulating tumor cells (CTCs) are a type of cancer cell that spreads from the main tumor to the bloodstream, and they are often the most important among the various entities that can be isolated from the blood. For the diagnosis of cancer, conventional biopsies are often invasive and unreliable, whereas a liquid biopsy, which isolates the affected item from blood or lymph fluid, is a less invasive and effective diagnostic technique. Microfluidic technologies offer a suitable channel for conducting liquid biopsies, and this technology is utilized to extract CTCs in a microfluidic chip by physical and bio-affinity-based techniques. This effort uses functionalized magnetic nanoparticles (MNPs) in a unique microfluidic chip to collect CTCs using a hybrid (physical and bio-affinity-based/guided magnetic) capturing approach with a high capture rate. Accordingly, folic acid-functionalized Fe3O4 nanoparticles have been used to capture MCF-7 (breast cancer) CTCs with capture efficiencies reaching up to 95% at a 10 µL/min flow rate. Moreover, studies have been conducted to support this claim, including simulation and biomimetic investigations.

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Microfluidic devices for the isolation and label-free identification of circulating tumor cells

Anwar,

Reis,

Zhang

et al. 2024

Chemical Engineering Journal

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Dual-source powered nanomotors coupled with dual-targeting ligands for efficient capture and detection of CTCs in whole blood and in vivo tumor imaging

Cited by 5 publications

References 28 publications

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Design and Application of Microfluidic Capture Device for Physical–Magnetic Isolation of MCF-7 Circulating Tumor Cells

Microfluidic devices for the isolation and label-free identification of circulating tumor cells

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