Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure

Mutlak, Michael; Kehat, Izhak

doi:10.1016/j.cellsig.2021.110033

Cited by 14 publications

(11 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DUSPs specifically dephosphorylate and inactivate MAPKs ( Liu and Molkentin, 2016 ). ERK1/2 plays a key role in cell growth, differentiation, and proliferation ( Mutlak and Kehat, 2021 ). Previous study has reported that DUSP6 may inhibit ERK1/2 ( Ramkissoon et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…DUSPs specifically dephosphorylate and inactivate MAPKs . ERK1/2 plays a key role in cell growth, differentiation, and proliferation (Mutlak and Kehat, 2021).…”

Section: Effects Of Sg On the Expression Of Dusp6mentioning

confidence: 99%

“…A strong link between MAPK signaling pathway and cardiac hypertrophy has been reported ( Singh et al, 2017 ). Among these three MAPKs, JNK and p38 attenuate cardiac hypertrophy by regulating pro-inflammation and stress, whereas ERK1/2 regulates cell growth, differentiation, and proliferation ( Mutlak and Kehat, 2021 ). The dephosphorylation of MAPKs is achieved via dual-specificity phosphatases (DUSPs; Liu and Molkentin, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway

Ding

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

Background: Cardiac hypertrophy as a main pathological manifestation of diabetic cardiomyopathy (DCM), is a significant complication of diabetes. Bariatric surgery has been proven to relieve DCM; however, whether it can alleviate diabetes-induced cardiac hypertrophy is undefined.Methods: Diabetic and obese rats were performed sleeve gastrectomy (SG) after having diabetes for 16weeks. The rats were euthanized 8weeks after SG. Metabolic parameters, heart function parameters, myocardial glucose uptake, morphometric and histological changes, and the expression level of mitogen-activated protein kinases (MAPKs) were determined and compared among the control group (CON group), diabetes mellitus group (DM group), sham operation group (SHAM group), and SG group.Results: Compared with the SHAM group, the blood glucose, body weight, insulin resistance, and other metabolic parameters were significantly improved in the SG group. There was also a marked improvement in myocardial morphometric and histological parameters after SG. Furthermore, the myocardial glucose uptake and heart function were reversed after SG. Additionally, the phosphorylation of MAPKs was inhibited after SG, including p38 MAPKs, c-Jun N-terminal kinases (JNKs), and extracellular signal-regulated kinases 1/2 (ERK1/2). The expression of DUSP6, which dephosphorylates ERK1/2, was upregulated after SG. These findings suggest that SG ameliorated diabetes-induced cardiac hypertrophy correlates with the MAPK signaling pathway.Conclusion: These results showed that diabetes-induced cardiac hypertrophy was ameliorated after SG was closely related to the inhibition of the MAPK signaling pathway and upregulation of DUSP6. Therefore, this study provides a novel strategy for treating diabetes-induced cardiac hypertrophy.

show abstract

Section: Resultsmentioning

confidence: 99%

“…DUSPs specifically dephosphorylate and inactivate MAPKs . ERK1/2 plays a key role in cell growth, differentiation, and proliferation (Mutlak and Kehat, 2021).…”

Section: Effects Of Sg On the Expression Of Dusp6mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway

Ding

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…GSEA found that the MAPK signaling pathway, PI3K-Akt signaling pathway, B cell receptor signaling pathway, cellular senescence, phagosomes, and other pathways related to HF are involved. Studies have reported the potential role of the MAPK signaling pathway and the PI3K-Akt signaling pathway in HF (Mutlak et al 2021;Qin et al 2021). The FAG collection related to HF was obtained by integrating the characteristic genes in the module with 259 ferroptosis-associated genes discovered in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Integrated bioinformatics and machine learning strategies reveal PRDX6 as the key ferroptosis-associated molecular biosignature of heart failure

Jiang¹,

Jiang²

2022

gpb

View full text Add to dashboard Cite

Heart failure (HF) is the leading cause of death and public health problems in the global population. This study aimed to identify and validate ferroptosis-related biomarkers associated with HF in clinical medicine using bioinformatics and machine learning strategies. Weighted co-expression network analysis (WGCNA) was applied to screen the module genes and analyze their biological functions and pathways. Ferroptosis-associated genes (FAG) in HF were determined and then machine learning algorithms were used for screening. Next, multiple external independent microarrays were used to verify molecular biosignature. Simultaneously, CIBERSORT was applied to estimate the immune infiltration landscape. Combined with the results of the WGCNA, 25 FAGs were determined and 6 FAMBs were selected by machine learning strategies. In addition, Peroxiredoxin 6 (PRDX6) was finally selected as the key ferroptosis-associated molecular biological feature based on multiple verifications of independent data sets. From the results of the infiltration and enrichment analysis, we believed that PRDX6, as a protective biomarker related to ferroptosis in HF, may help provide new ideas in the immunotherapy of HF.

show abstract

“…The dual speci c phosphatase (DUSP) family is characterized by dephosphorylating its substrates on the tyrosine and serine/threonine residue [12]. Several DUSPs could dephosphorylate and suppress the activation of MAPK and JAK/STAT signaling pathway which are important regulators in cardiac hypertrophy [13,14]. A recent study found that DUSP19 could ameliorate apoptosis and in ammatory through inhibiting NF-κB signaling in spinal cord injury [15].…”

Section: Introductionmentioning

confidence: 99%

Dual-Specificity Phosphatase 19 Alleviates Cardiac Hypertrophy Via Inhibiting ASK1 Phosphorylation

Jia

Liu

et al. 2022

SSRN Journal

View full text Add to dashboard Cite

Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure

Cited by 14 publications

References 64 publications

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway

Integrated bioinformatics and machine learning strategies reveal PRDX6 as the key ferroptosis-associated molecular biosignature of heart failure

Dual-Specificity Phosphatase 19 Alleviates Cardiac Hypertrophy Via Inhibiting ASK1 Phosphorylation

Contact Info

Product

Resources

About