Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

Salinas, Yolanda; Kneidinger, Michael; Fornaguera, Cristina; Borrós, Salvador; Brüggemann, Oliver; Teasdale, Ian

doi:10.1039/d0ra03210g

Cited by 17 publications

(16 citation statements)

References 39 publications

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“…Recently, an interesting study utilized MSNs with gatekeepers responsive to both temperature and pH for a more regulated delivery of chemotherapeutics into lung cancer cells [176]. Two strategies are commonly used for the preparation of MSNs for targeted and controlled release.…”

Section: Drug Releasementioning

confidence: 99%

“…In this approach, the disulfide bonds between the redox-responsive gatekeeper and MSNs are cleaved by GSH, leading to the cap opening and subsequent drug release [ 163 , 173 , 174 , 175 ]. Recently, an interesting study utilized MSNs with gatekeepers responsive to both temperature and pH for a more regulated delivery of chemotherapeutics into lung cancer cells [ 176 ]. Two strategies are commonly used for the preparation of MSNs for targeted and controlled release.…”

Section: The Fundamentals Of Msn-based Drug Deliverymentioning

confidence: 99%

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An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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Section: Drug Releasementioning

confidence: 99%

Section: The Fundamentals Of Msn-based Drug Deliverymentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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“…t ∈ [0, t rel ]. An explicit closed-form expression for the normalized number of released molecules as a function of time t can be obtained by inserting (7) into (8). The validity of the simplified model ( 7), ( 8) is discussed in Section VI.…”

Section: A Gradual Release Processmentioning

confidence: 99%

“…The MC framework is a promising approach to design drug delivery (DD) systems, where nanoparticle carriers deliver drug molecules to diseased cell sites and release them at the right time and rate [4]- [7]. This targeted delivery reduces potential side effects on non-target sites and helps mitigate toxicity, drug wastage, and healthcare costs compared to conventional treatment options.…”

Section: Introductionmentioning

confidence: 99%

Channel Responses for the Molecule Release from Spherical Homogeneous Matrix Carriers

Schäfer¹,

Salinas²,

Ruderer³

et al. 2021

Preprint

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Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel in between are modeled as transmitters, absorbing receivers, and diffusive channel, respectively. However, existing works on drug delivery systems consider only simple drug carrier models, which limits their practical applicability. In this paper, we investigate diffusion-based spherical matrix-type drug carriers, which are employed in medical applications. In a matrix carrier, the drug molecules are dispersed in the matrix core and diffuse from the inner to the outer layers of the carrier once immersed in a dissolution medium.We derive the channel response of the matrix carrier transmitter for an absorbing receiver. The results are validated by particle-based simulations and compared with commonly used point and transparent spherical transmitters to highlight the necessity of considering practical models. Moreover, we show that a transparent spherical transmitter, with the drug molecules uniformly distributed over the entire volume, is a special case of the considered matrix system. For this case, we provide an analytical expression for the channel response. Furthermore, we derive a criterion for evaluating whether the release process or the channel dynamics are more important for the characteristics of the channel response of a drug delivery system. For the limiting regimes, where only the release process or only the channel determine the behavior of the end-to-end system, we propose closed-form approximations for the channel response.Finally, as a scenario of practical relevance, we investigate the channel responses for the release of common therapeutic drugs, e.g., doxorubicin, from a diblock copolymer micelle acting as drug carrier.

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“…The ones with substituents such as amino acid esters and peptide esters constitute the largest group of degradable polyphosphazenes and have been extensively investigated and developed as tissue constructs for bone regenerative engineering (Allcock & Morozowich, 2012; Ogueri & Laurencin, 2018). Also, degradable polyphosphazenes have shown promise in their applications as carriers for the controlled release of bioactive and therapeutic molecules (Ogueri et al, 2020a; Salinas et al, 2020; Strasser & Teasdale, 2020). The process of tissue regeneration and the release of immobilized molecules can be controlled and regulated by modulating the degradation of polyphosphazenes (Ni et al, 2020; Ogueri, Allcock, et al, 2019; Ogueri et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of polyphosphazenes

Ogueri

Ude

et al. 2020

Med Devices & Sens

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Although numerous conventional organic polymers have been utilized in biomedical applications, a few numbers of them have had expected and desired success for essential medical use such as scaffolding materials for regenerative engineering, controlled drug delivery systems, and surgical sutures (Ogueri, Jafari, Ivirico, & Laurencin, 2019). This is because most organic polymers (with few exceptions) lack the design flexibility and property tunability as materials scientist and engineers often focus on harnessing and optimizing the physicochemical properties of polymers during design, scale-up, and commercialization (Ogueri, Ivirico, Nair, Allcock,

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Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

Abstract: Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

Cited by 17 publications

References 39 publications

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

Channel Responses for the Molecule Release from Spherical Homogeneous Matrix Carriers

Biomedical applications of polyphosphazenes

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