Dual stimuli-sensitive dendrimers: Photothermogenic gold nanoparticle-loaded thermo-responsive elastin-mimetic dendrimers

Fukushima, Daichi; Sk, Ugir Hossain; Sakamoto, Yasuhiro; Nakase, Ikuhiko; Kojima, Chie

doi:10.1016/j.colsurfb.2015.05.012

Cited by 31 publications

(32 citation statements)

References 28 publications

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“…The sample temperature was measured by SK-1250MC (Sato Keiryoki MFG. Co., Ltd., Tokyo, Japan) immersed in the solution of the cell [23].…”

Section: Photothermal Measurementmentioning

confidence: 99%

“…After culture at 37°C for 24 h in Dulbecco's modified Eagle's medium with 10% fetal bovine serum, the medium was replaced with Opti-MEM containing AuNP-loaded dendrimers ([Au] = 200 µM, 100 µL) and incubated at 25°C and 37°C for 6 h. The cells were then washed with phosphate-buffered saline (PBS) twice, and fresh Opti-MEM (100 µL) was added to the cells. The cells were irradiated by green laser light (532 nm, 50 mW,  6.9 µm) at 37°C using a Thermo Plate (TR-110R05, Tokai Hit Co. Ltd., Shizuoka, Japan) for 1 min, and with a fluorescence microscope (IX71, Olympus Co., Tokyo, Japan) equipped with a laser irradiation system (SIGMA KOKI Co., Ltd., Tokyo, Japan) [23]. The live or dead assay was performed according to our previous reports [16,23].…”

Section: Phototoxicitymentioning

confidence: 99%

“…The cells were irradiated by green laser light (532 nm, 50 mW,  6.9 µm) at 37°C using a Thermo Plate (TR-110R05, Tokai Hit Co. Ltd., Shizuoka, Japan) for 1 min, and with a fluorescence microscope (IX71, Olympus Co., Tokyo, Japan) equipped with a laser irradiation system (SIGMA KOKI Co., Ltd., Tokyo, Japan) [23]. The live or dead assay was performed according to our previous reports [16,23].…”

Section: Phototoxicitymentioning

confidence: 99%

“…AuNP-loaded ELP-den and PEG-den were prepared according to our previous report [15,23]. Purification and condensation of AuNP solutions were performed by ultrafiltration with Amicon Ultra 3000 Da (Merck KGaA, Darmstadt, Germany), if necessary.…”

Section: Experimental 21 Materialsmentioning

confidence: 99%

“…AuNP-loaded elastin-mimetic dendrimers (ELP-den) and PEG-den were previously prepared [15,23]. These photo-and thermo-responsive properties were analyzed by ultraviolet-visible (UV-Vis) spectrometry, photothermal measurement and dynamic light scattering (DLS) and compare them.…”

Section: Introductionmentioning

confidence: 99%

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Applications of Gold Nanoparticle-Loaded Thermosensitive Elastin-Mimetic Dendrimer to Photothermal Therapy

Kojima

Fukushima

2016

J. Photopol. Sci. Technol.

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Gold nanoparticles (AuNPs) have photo-induced heat-generating properties, which can be applied to photothermal therapy. Dendrimers are synthetic macromolecules with a unique structure, and work as nanotemplates in the preparation of AuNPs, as well as potent vehicles. Previously, PEGylated dendrimer (PEG-den) has been used as a vehicle of AuNP. Thermosensitive elastin-mimetic dendrimers were previously prepared as a biocompatible thermosensitive nanoparticle by conjugating elastin-like peptides (ELPs) with valine-proline-glycine-valine-glycine (VPGVG) repeats to dendrimers. In this study, elastin-mimetic dendrimer (ELP-den) was used as a thermosensitive vehicle of AuNP. The AuNP-loaded ELP-den exhibited both photothermal and thermosensitive properties. AuNP-loaded ELP-den readily associated with cells and induced efficient photocytotoxicity, but the AuNP-loaded PEG-den did not. This suggests that ELP-den is a potent carrier of AuNPs for photothermal therapy.

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“…The sample temperature was measured by SK-1250MC (Sato Keiryoki MFG. Co., Ltd., Tokyo, Japan) immersed in the solution of the cell [23].…”

Section: Photothermal Measurementmentioning

confidence: 99%

Section: Phototoxicitymentioning

confidence: 99%

Section: Phototoxicitymentioning

confidence: 99%

Section: Experimental 21 Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Applications of Gold Nanoparticle-Loaded Thermosensitive Elastin-Mimetic Dendrimer to Photothermal Therapy

Kojima

Fukushima

2016

J. Photopol. Sci. Technol.

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Applications of Temperature‐Responsive Polymers Grafted onto Solid Core Nanoparticles

Mansfield

Williams

Khutoryanskiy

2018

Temperature‐Responsive Polymers

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A Naked‐eye Colorimetric pH and Temperature Sensor Based on Gold Nanoparticle‐Loaded Stimuli‐Sensitive Dendrimers

et al. 2022

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Gold nanoparticles (AuNPs) show unique size-and shape-dependent photosensitive properties resulting from localized surface plasmon resonance, which can be exploited in colorimetric sensors. Polyamidoamine (PAMAM) dendrimers are suitable nanotemplates of AuNPs and nanoplatforms of some stimuli-responsive materials. In this study, AuNP was loaded in phenylalanine (Phe)-modified PAMAM dendrimers with dual pH-and temperature-sensitive properties to produce a naked-eye colorimetric sensor with responsivity to both pH and temperature. The ultraviolet-visible (UV-Vis) spectra of AuNP-loaded PAMAM-Phe-Suc were changed by heating at pH 4 and 5, but unchanged at pH above 5.5. The UV-Vis spectra of AuNP-loaded PAMAM-Phe and PAMAM-Suc were only slightly changed by heating at pH above 5.5 and at pH 4 and 5, respectively. In solution, AuNP-loaded PAMAM-Phe-Suc changed color (from brown to gray) under high temperature (� 50 °C) and acidic (pH � 5) conditions, suggesting its functionality as a naked-eye colorimetric dual pH and temperature sensor.

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Dual stimuli-sensitive dendrimers: Photothermogenic gold nanoparticle-loaded thermo-responsive elastin-mimetic dendrimers

Cited by 31 publications

References 28 publications

Applications of Gold Nanoparticle-Loaded Thermosensitive Elastin-Mimetic Dendrimer to Photothermal Therapy

Applications of Gold Nanoparticle-Loaded Thermosensitive Elastin-Mimetic Dendrimer to Photothermal Therapy

Applications of Temperature‐Responsive Polymers Grafted onto Solid Core Nanoparticles

A Naked‐eye Colorimetric pH and Temperature Sensor Based on Gold Nanoparticle‐Loaded Stimuli‐Sensitive Dendrimers

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