Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer

Gao, Dan; Asghar, Sajid; Ye, Junxiu; Zhang, Mei; Hu, Rongfeng; Wang, Yadong; Huang, Lin; Yuan, Chengjun; Chen, Zhipeng; Xiao, Yanyu

doi:10.1016/j.carbpol.2022.119785

Cited by 23 publications

(14 citation statements)

References 73 publications

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“…They can be obtained for submicronization of macroscopic hydrogels prepared through self-assembly of natural or synthetic polymers (e.g., chitosan, cellulose, agarose, hyaluronic acid, etc.) or, as an alternative, of peptide sequences [ 22 , 23 , 24 , 25 , 26 ]. Due to their biocompatibility, biodegradability, and mild preparation conditions (they do not require the use of extreme pH and temperature values), peptide-based NGs seem to be a promising platform for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Smaldone¹,

Rosa

Gallo³

et al. 2023

Pharmaceutics

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Introduction: Hydrogel nanoparticles, also known as nanogels (NGs), have been recently proposed as alternative supramolecular vehicles for the delivery of biologically relevant molecules like anticancer drugs and contrast agents. The inner compartment of peptide based NGs can be opportunely modified according to the chemical features of the cargo, thus improving its loading and release. A full understanding of the intracellular mechanism involved in nanogel uptake by cancer cells and tissues would further contribute to the potential diagnostic and clinical applications of these nanocarriers, allowing the fine tuning of their selectivity, potency, and activity. The structural characterization of nanogels were assessed by Dynamic Light Scattering (DLS) and Nanoparticles Tracking Analysis (NTA) analysis. Cells viability of Fmoc-FF nanogels was evaluated by MTT assay on six breast cancer cell lines at different incubation times (24, 48, and 72 h) and peptide concentrations (in the range 6.25 × 10−4 ÷ 5·10−3 × wt%). The cell cycle and mechanisms involved in Fmoc-FF nanogels intracellular uptake were evaluated using flow cytometry and confocal analysis, respectively. Fmoc-FF nanogels, endowed with a diameter of ~130 nm and a zeta potential of ~−20.0/−25.0 mV, enter cancer cells via caveolae, mostly those responsible for albumin uptake. The specificity of the machinery used by Fmoc-FF nanogels confers a selectivity toward cancer cell lines overexpressing the protein caveolin1 and efficiently performing caveolae-mediated endocytosis.

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Section: Introductionmentioning

confidence: 99%

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Smaldone¹,

Rosa

Gallo³

et al. 2023

Pharmaceutics

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“…Cancer treatment [ 186] Nanogel HA Paclitaxel Enzyme-sensitive targeting Breast cancer treatment [ 187] Nanogel HA and 𝛽-CD derivative Auraptene and cisplatin pH-responsive, targeted delivery Synergistic therapy for breast cancer and cell imaging [ 188] Nanogel Poly (ethylene glycol) conjugated HA Cytochrome C Hypoxia response CD44 mediated tumor targeting [ 189] Nanogel Pluronic L61 linked HA Acid-sensitive capacity Cancer treatment [ 190] Nanogel HA, cisplatin, cancer cell membrane…”

Section: Cancer Treatmentmentioning

confidence: 99%

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Luo,

Wang,

et al. 2023

Adv Funct Materials

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Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.

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“…Gao et al 93 created a specific nanogel system for treating breast cancer by combining CD44 and biotin receptors, wherein they were loaded with paclitaxel (PTX/Bio-NG). After fabrication using enzyme-sensitive hyaluronic acid, nanogels exhibited a spherical shape with an average particle size of 149.1 AE 1.6 nm (Fig.…”

Section: Enzyme-responsive Polysaccharide Nanohydrogelmentioning

confidence: 99%

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Damiri,

Fatimi,

Santos

et al. 2023

J. Mater. Chem. B

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Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer

Cited by 23 publications

References 73 publications

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

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