Dual-targeted poly(amino acid) nanoparticles deliver drug combinations on-site: an intracellular synergistic strategy to eliminate intracellular bacteria

Abstract

The on-site drug delivery system delivers the drug combination in a synergistic dose to efficiently eliminate intracellular bacteria.

Intracellular infection-responsive macrophage-targeted nanoparticles for synergistic antibiotic immunotherapy of bacterial infection

“…The barrier function of host cells not only enables intracellular S. aureus to evade the attack of the host immune system but also prevents traditional antibiotics from killing intracellular bacteria. 64,65 Herein, ox-Dex-Se/Van nanoparticles were prepared to eradicate intracellular bacteria through targeted antibiotic delivery, cellular ROS generation, and proinflammatory upregulation. To investigate the intracellular antibacterial activities of ox-Dex-Se, Van and ox-Dex-Se/Van nanoparticles, antibacterial materials with different concentrations were used to treat S. aureus-infected RAW 264.7 cells.…”

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

“…However, the emergence of drug-resistant strains has rendered many conventional antibiotics ineffective. 11,12 In recent years, photodynamic therapy has gradually entered the clinical treatment of bacterial infections due to its advantages of low dark toxicity, high selectivity and low risk of bacterial resistance. 13–16 However, for wound infections caused by Gram-negative bacteria, some small-molecule photosensitizers are unable to impart the expected effect due to the inability to counteract the outer membrane barrier.…”