Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma

Ni, Wenfeng; Li, Zhengye; Liu, Zengquan; Ji, Yuting; Wu, Lijun; Sun, Shan; Jian, Xiqi; Gao, Xiujun

doi:10.1016/j.xphs.2018.10.042

Cited by 65 publications

(37 citation statements)

References 53 publications

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“…PLGA has also been used in combination with poly(ethylene glycol) (PEG), which is widely applied in many biomedical applications due to its biocompatibility and high hydrophilic properties. Ni et al developed biotin-/lactobionic acid-modified poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol) (BLPP) copolymer NPs to deliver curcumin-and 5-fluorouracil [60]. The biotin and lactobionic acid served as dual targeting agents and they were linked to the amphiphilic triblock PEG-PLGA-PEG.…”

Section: Plga-based Npsmentioning

confidence: 99%

“…Abdelmoneed delivered two phytochemicals extracted from plants; berberine (BRB) and diosmin (DSN) using micelles [85]. Ni et al delivered both curcumin-and 5-fluorouracil-loaded with biotin-/lactobionic acid-modified PEG-PLGA-PEG (BLPP) copolymer NPs and saw synergistic anticancer effects (i.e., cytotoxicity) in vivo [60]. Curcumin is a polyphenol extracted from turmeric inducing anti-angiogenic, antitumor, and anti-inflammatory physiological responses [122].…”

Section: Natural Occurring Compoundsmentioning

confidence: 99%

“…The pullulan polysaccharide backbone in their biomaterials bind naturally to ASGP-Rs as shown in Figure 5 [136]. Ni et al used a dual targeting approach to target HCC cells [60]. Poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol) (BLPP) copolymer NPs were synthesized and conjugated with biotin-/lactobionic acid for targeted delivery of curcumin-and 5-fluorouracil.…”

Section: Carbohydrate-targeting Agentsmentioning

confidence: 99%

“…Poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol) (BLPP) copolymer NPs were synthesized and conjugated with biotin-/lactobionic acid for targeted delivery of curcumin-and 5-fluorouracil. Due to the dual targeting, a higher cellular uptake was seen in HCC cells, and a lower residual accumulation was seen in normal tissue in comparison to the single targeting and non-targeting NPs [60]. Similarly, Abdelmoneem et al used lactobionic acid and folic acid to target nanomicelles loaded with the phytochemicals berberine (BRB) and diosmin (DSN) to HCC cells [85].…”

Section: Carbohydrate-targeting Agentsmentioning

confidence: 99%

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Liver Cancer: Current and Future Trends Using Biomaterials

Chew

Moscato

George

et al. 2019

Cancers

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Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review summarizes the current biomaterial-based approaches for systemic delivery and implantable tools for locally administrating bioactive factors and provides a comprehensive discussion of the specific therapies and targeting agents to efficiently deliver those factors. This review also highlights the novel application of biomaterials to study HCC, which includes hydrogels and scaffolds to tissue engineer 3D in vitro models representative of the tumor environment. Such models will serve to better understand the tumor biology and investigate new therapies for HCC. Special focus is given to innovative approaches, e.g., combined delivery therapies, and to alternative approaches—e.g., cell capture—as promising future trends in the application of biomaterials to treat HCC.

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Section: Plga-based Npsmentioning

confidence: 99%

Section: Natural Occurring Compoundsmentioning

confidence: 99%

Section: Carbohydrate-targeting Agentsmentioning

confidence: 99%

Section: Carbohydrate-targeting Agentsmentioning

confidence: 99%

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Liver Cancer: Current and Future Trends Using Biomaterials

Chew

Moscato

George

et al. 2019

Cancers

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“…PLGA nanoparticles was used for sustained and controlled drug delivery with improved bioavailability of hydrophobic compounds such as curcumin [12]. 5-fluorouracil (5Fu) is a broadly used chemotherapy drug in various cancers such as colon cancer, liver cancer [13,14]. As an antimetabolite analogue of pyrimidine, 5Fu inhibited nucleoside metabolism and DNA synthesis, thereby resulting in cell apoptosis [15].…”

mentioning

confidence: 99%

Enhanced antitumor efficacy on colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perﬂuorocarbon

Wu¹,

Zhou²,

Zhu³

et al. 2019

Preprint

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Recurrence and metastasis are the shortcomings of the clinical treatment of colon cancer. Finding an efficacy strategy for the treatment of colon cancer is important. In recent years, PLGA has been shown to have potential as a broad therapeutic drug delivery system. this study aimed to design a dual-loaded nanoparticles drug delivery system to overcome the limitations of chemotherapeutic drugs in colon cancer therapy. We developed epidermal growth factor (EGF) functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) co-loaded with 5-fluorouracil (5Fu) and perﬂuorocarbon (PFC) (EGF-PLGA@5Fu/PFC) for target therapy of colon cancer. EGF-PLGA@5Fu /PFC NPs were estimated to have an average size of 200 nm with a 5Fu-loading efficiency of 7.29%. In vitro release profile exhibited a pH-responsive release. CCK-8, Hoechst33342 staining and flow cytometry assays were performed to investigate the functions of EGF-PLGA@5Fu/PFC NPs in SW620 cells. Targeted EGF-PLGA@5Fu/PFC NPs also exhibited higher cellular uptake than non-targeted NPs in colon cancer cells. EGF-PLGA@5Fu/PFC NPs were found to have the best efficiency on cell viability suppression and apoptosis induction in SW620 cells. In xenograft mice, EGF-PLGA@5Fu/PFC NPs had the best suppressive effects on tumor growth compared with 5Fu, PLGA@5Fu and PLGA@5Fu/PFC NPs. The results of histopathological analysis further indicated that EGF-targeted NPs were the most efficient on tumor growth inhibition. Mechanically, the data demonstrated the improved therapeutic outcomes were owing to the fact that PFC could relieve tumor hypoxia via transporting oxygen to the tumor. We creatively constructed a biocompatible nanodrug delivery system and functionalized nanoparticles may provide new potential for selective delivery of chemotherapy drugs to cancers.

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