Dual targeting procyanidin nanoparticles with glutathione response for colitis treatment

Hepatic parenchymal cell and mitochondrial-targeted astaxanthin nanocarriers for relief of high fat diet-induced nonalcoholic fatty liver disease

“…Tie et al also found similar results, when they developed a double-targeted and glutathione response procyanidin nanocarriers with stability in simulated intestinal fluid. 23…”

“…HepG2 cells were seeded in laser confocal dishes with DMEM containing penicillin (1%) and fetal bovine serum (15%), and incubated with the nanocarriers labeled by red fluorescence for 2 h and 4 h. Subsequently, the cells were stained with a MitoTracker green fluorescent probe and detected by confocal laser fluorescence microscopy (Leica Microsystems GmbH., Wetzlar, Germany). 23 Biocompatibility, cellular antioxidant, anti-lipogenic and mitochondria energy metabolism of AST@TPP-WPI-Gal nanocarriers in vitro…”

Pickering emulsions stabilized by Chlorella pyrenoidosa protein–chitosan complex for lutein encapsulation

“…Therefore, it is necessary to develop a delivery system for lutein to improve its stability and bioavailability. 2–4…”

“…Therefore, it is necessary to develop a delivery system for lutein to improve its stability and bioavailability. [2][3][4] At present, many delivery systems including emulsions, nanoparticles and liposomes have been demonstrated as effective ways to improve the stability and bioavailability of natural nutrients. [5][6][7][8] Pickering emulsions are also considered as one of the most promising delivery systems on account of the good physical stability, simple preparation process and high loading rate.…”

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

“…202 Excitingly, the functional groups of chitosan, i.e., amine and hydroxyl groups, have the ability to combine with the above linkers, and this application has been reviewed by Sabourian et al 203 All of these studies could guide the delivery of polyphenols in the future, and the application of multi-targets is considered as a promising strategy for designing OCDSs that integrate the specific aggregation (a), uptake (b), and release of drugs (c) (Fig. 5), which has been referenced by some researches 204,205 to deliver polyphenols to the colon.…”