Dual-threshold Time-over-Threshold nonlinearity correction for PET detectors

Gaudin, Émilie; Thibaudeau, Christian; Arpin, Louis; Bouziri, Haithem; Fontaine, R.

doi:10.1016/j.nima.2020.164100

Cited by 7 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, at the time of the measurements this procedure was not implemented in the scanner and a global correction was deemed sufficient. Further investigations to recalibrate the scanner using more advanced non-linearity correction (Gaudin et al 2020) are expected to reduce this discrepancy. Finally, the coincidence processor rejects all triple or higher order coincidences that cannot be assigned a single unambiguous LOR.…”

Section: Discussionmentioning

confidence: 99%

“…An automated procedure seeking the APD breakdown voltage while monitoring the signal baseline was used to operate the detector arrays at optimal bias maximizing the signal/noise ratio. The inherent non-linearity of the ToT signal (Orita et al 2011) was corrected using average corrections factors based on an energy calibration procedure using a single γ-ray source and a variation of the ASIC internal electronic gain (Gaudin et al 2020). Unless otherwise stated, measurements were performed using an effective energy window of 350-650 keV and a coincidence time window of 10 ns.…”

Section: System Calibrationmentioning

confidence: 99%

See 1 more Smart Citation

Performance evaluation of the mouse version of the LabPET II PET scanner

Gaudin¹,

Thibaudeau²,

Arpin³

et al. 2021

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

The LabPET II is a new positron emission tomography technology platform designed to achieve submillimetric spatial resolution imaging using fully pixelated avalanche photodiodes-based detectors and highly integrated parallel front-end processing electronics. The detector was designed as a generic building block to develop devices for preclinical imaging of small to mid-sized animals and for clinical imaging of the human brain. The aim of this work is to assess the physical characteristics and imaging performance of the mouse version of LabPET II scanner following the NEMA NU4-2008 standard and using high resolution phantoms and in vivo imaging applications. A reconstructed spatial resolution of 0.78 mm (0.5 μ l) is measured close to the center of the radial field of view. With an energy window of 350 650 keV, the system absolute sensitivity is 1.2% and its maximum noise equivalent count rate reaches 61.1 kcps at 117 MBq. Submillimetric spatial resolution is achieved in a hot spot phantom and tiny bone structures were resolved with unprecedented contrast in the mouse. These results provide convincing evidence of the capabilities of the LabPET II technology for biomolecular imaging in preclinical research.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: System Calibrationmentioning

confidence: 99%

Performance evaluation of the mouse version of the LabPET II PET scanner

Gaudin¹,

Thibaudeau²,

Arpin³

et al. 2021

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are two commonly used charge measurement methods in PET electronics, namely direct digitization through an ADC chip [15] with digital peak detection or integration, and time-overthreshold (TOT) with TDC digitization [16]. Several FPGA-based measurement methods have also been proposed on the basis of these two methods [24,28,29].…”

Section: Introductionmentioning

confidence: 99%

Prototype of a digitizer module based on multicycle-encoding FPGA ADC for a small animal PET

et al. 2023

View full text Add to dashboard Cite

Current research in small animal positron emission tomography (PET) scanners focus on obtaining better spatial resolution and higher sensitivity. These enhancements of scanner performance result in a corresponding increase in the complexity of the electronics, which usually manifests through an increase in the number of electronics channels. Analog-to-digital converters (ADCs) implemented in field programmable gate arrays (FPGAs) are an effective way to simplify electronics complexity. In this paper, a resource-saving multicycle-encoding structure of an FPGA-based ADC with automated calibration is proposed, which achieves a sampling rate of 250 Msps. A digitizer module prototype containing 64 charge measurement channels based on the FPGA ADC is designed using a Kintex-7 FPGA. The effective number of bits (ENOB) achieved using the FPGA ADC is 4.26 bits under a 10.0555 MHz sine wave input. The charge measurement resolution of each channel is better than 5‰ full width half maximum under a 0.8 V signal input and 3% under inputs in the range 0.1 V to 1.2 V. The integral nonlinearity of each channel is within ± 1%.

show abstract

Low-dose PET image denoising based on coupled dictionary learning

et al. 2021

Nuclear Instruments and Methods in Physics Research Section A:

View full text Add to dashboard Cite

Dual-threshold Time-over-Threshold nonlinearity correction for PET detectors

Cited by 7 publications

References 21 publications

Performance evaluation of the mouse version of the LabPET II PET scanner

Performance evaluation of the mouse version of the LabPET II PET scanner

Prototype of a digitizer module based on multicycle-encoding FPGA ADC for a small animal PET

Low-dose PET image denoising based on coupled dictionary learning

Contact Info

Product

Resources

About