Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma

Shinya, Takayoshi; Fujii, Soichiro; Shoji, Akira; Taniguchi, Toshitaka; Yoshio, Kotaro; Alafate, Aierken; Sato, Shuhei; Yoshino, Tadashi; Kanazawa, Susumu

doi:10.1007/s12149-012-0619-y

Cited by 31 publications

(24 citation statements)

References 18 publications

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“…Zhuang et al [12] suggested that dual-time-point 18 F-FDG PET imaging has a potential role in distinguishing malignancy from benign process, on the basis of the different time-activity responses in 18 F-FDG uptake patterns in both in vitro and in vivo studies. Other investigators have found controversial results on using dual-time-point acquisition of 18 F-FDG PET/CT for various malignant diseases [13–17]. …”

Section: Introductionmentioning

confidence: 99%

The Clinical Role of Dual-Time-Point 18F-FDG PET/CT in Differential Diagnosis of the Thyroid Incidentaloma

Lee

Park

et al. 2013

Nucl Med Mol Imaging

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Thyroid incidentalomas are common findings during imaging studies including 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for cancer evaluation. Although the overall incidence of incidental thyroid uptake detected on PET imaging is low, clinical attention should be warranted owing to the high incidence of harboring primary thyroid malignancy. We retrospectively reviewed 2,368 dual-time-point 18F-FDG PET/CT cases that were undertaken for cancer evaluation from November 2007 to February 2009, to determine the clinical impact of dual-time-point imaging in the differential diagnosis of thyroid incidentalomas. Focal thyroid uptake was identified in 64 PET cases and final diagnosis was clarified with cytology/histology in a total of 27 patients with 18F-FDG-avid incidental thyroid lesion. The maximum standardized uptake value (SUVmax) of the initial image (SUV1) and SUVmax of the delayed image (SUV2) were determined, and the retention index (RI) was calculated by dividing the difference between SUV2 and SUV1 by SUV1 (i.e., RI = [SUV2 - SUV1]/SUV1 × 100). These indices were compared between patient groups that were proven to have pathologically benign or malignant thyroid lesions. There was no statistically significant difference in SUV1 between benign and malignant lesions. SUV2 and RI of the malignant lesions were significantly higher than the benign lesions. The areas under the ROC curves showed that SUV2 and RI have the ability to discriminate between benign and malignant thyroid lesions. The predictability of dual-time-point PET parameters for thyroid malignancy was assessed by ROC curve analyses. When SUV2 of 3.9 was used as cut-off threshold, malignancy on the pathology could be predicted with a sensitivity of 87.5 % and specificity of 75 %. A thyroid lesion that shows RI greater than 12.5 % could be expected to be malignant (sensitivity 88.9 %, specificity 66.3 %). All malignant lesions showed an increase in SUVmax on the delayed images compared with the initial images. But in the group of benign lesions, 37.5 % (6/16) showed a decrease or no change in SUVmax. Dual-time-point 18F-FDG PET/CT, obtaining additional images 2 h after injection, seems to be a complementary method for the differentiation between malignancy and benignity of incidental thyroid lesions.

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Section: Introductionmentioning

confidence: 99%

The Clinical Role of Dual-Time-Point 18F-FDG PET/CT in Differential Diagnosis of the Thyroid Incidentaloma

Lee

Park

et al. 2013

Nucl Med Mol Imaging

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“…In these numerous studies, attempts have been made to qualify and quantify the impact of the length of the injection-to-scan time interval on differentiating malignant processes from benign processes. As one might expect, the findings reported amongst these various investigators have been highly variable, with some supporting the use of delayed phase and dual-time-point diagnostic 18 F-FDG PET imaging approaches [66-77,81-84,86,87,91-93,95-100,103-108,110,111,113,114,117-122,124-128,131,133,134,136,138,141,143,146,149,152,153,155,157,160-163,165,167,169], and with others not [65,78,89,90,94,101,102,109,115,116,123,129,130,132,135,137,139,140,147,148,150,151,156,158,164,166,168]. …”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution 18F-FDG-directed surgery experience: feasibility and quantification of 18F-FDG accumulation within 18F-FDG-avid lesions and background tissues

et al. 2014

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Background18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is a well-established imaging modality for a wide variety of solid malignancies. Currently, only limited data exists regarding the utility of PET/CT imaging at very extended injection-to-scan acquisition times. The current retrospective data analysis assessed the feasibility and quantification of diagnostic 18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals.Methods18F-FDG-avid lesions (not surgically manipulated or altered during 18F-FDG-directed surgery, and visualized both on preoperative and postoperative 18F-FDG PET/CT imaging) and corresponding background tissues were assessed for 18F-FDG accumulation on same-day preoperative and postoperative 18F-FDG PET/CT imaging. Multiple patient variables and 18F-FDG-avid lesion variables were examined.ResultsFor the 32 18F-FDG-avid lesions making up the final 18F-FDG-avid lesion data set (from among 7 patients), the mean injection-to-scan times of the preoperative and postoperative 18F-FDG PET/CT scans were 73 (±3, 70-78) and 530 (±79, 413-739) minutes, respectively (P < 0.001). The preoperative and postoperative mean 18F-FDG-avid lesion SUVmax values were 7.7 (±4.0, 3.6-19.5) and 11.3 (±6.0, 4.1-29.2), respectively (P < 0.001). The preoperative and postoperative mean background SUVmax values were 2.3 (±0.6, 1.0-3.2) and 2.1 (±0.6, 1.0-3.3), respectively (P = 0.017). The preoperative and postoperative mean lesion-to-background SUVmax ratios were 3.7 (±2.3, 1.5-9.8) and 5.8 (±3.6, 1.6-16.2), respectively, (P < 0.001).Conclusions18F-FDG PET/CT oncologic imaging can be successfully performed at extended injection-to-scan acquisition time intervals of up to approximately 5 half-lives for 18F-FDG while maintaining good/adequate diagnostic image quality. The resultant increase in the 18F-FDG-avid lesion SUVmax values, decreased background SUVmax values, and increased lesion-to-background SUVmax ratios seen from preoperative to postoperative 18F-FDG PET/CT imaging have great potential for allowing for the integrated, real-time use of 18F-FDG PET/CT imaging in conjunction with 18F-FDG-directed interventional radiology biopsy and ablation procedures and 18F-FDG-directed surgical procedures, as well as have far-reaching impact on potentially re-shaping future thinking regarding the “most optimal” injection-to-scan acquisition time interval for all routine diagnostic 18F-FDG PET/CT oncologic imaging.

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“…badanie całego ciała lub wybranego regionu), analizę czasowo-przestrzenną rozkładu radioznacznika w obrębie obserwowanej zmiany, co może zwiększyć czułość, specyficzność i dokładność badania, a tym samym prawdopodobieństwo podjęcia właściwej decyzji diagnostycznej [21][22][23].…”

Section: Wstępunclassified

“…Wcześniejsze publikacje podają, że badania opóźnione podnoszą czułość i swoistość metody 18 F-FDG PET/CT i mogą służyć codziennej praktyce klinicznej [4,11,[20][21][22][23].…”

Section: Dyskusjaunclassified

“…Otrzymany spadek w strukturach fizjologicznych oraz wzrost w obrębie zmian łagodnych oraz zmian złośliwych wskazuje jednakże na konieczność pogłębienia analizy celem wyznaczenia właściwego punktu odcięcia wartości SUVmax 90 minut po iniekcji radiofarmaceutyku. Z danych literaturowych wynika, że wzrastająca w czasie retencja znacznika w obszarze zmian łagodnych utrudnia diagnostykę różnicową, podnosząc średnią wartość parametru SUV w stosunku do reszty analizowanych obszarów [14][15][20][21][22][23].…”

Section: Dyskusjaunclassified

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Ocena przydatności badań opóźnionych 18F-FDG PET/CT w różnicowaniu zmian łagodnych i złośliwych

Pietrzak

Smoleń

Cholewiński

2017

los

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StreszczenieCelem pracy była ocena użyteczności badań opóźnionych w diagnostyce różnicowej zmian łagodnych i złośliwych regionu głowy i szyi. 27 mężczyzn (średnia wieku: 62±4 lata, przedział wiekowy: 54-67 lata) poddano badaniom dwufazowym pozytonowej tomografii emisyjnej/tomografii komputerowej z użyciem radiofarmaceutyku fluoro-18-deoksyglukoza ( 18 F-FDG-PET/CT). We wszystkich przypadkach analizowano struktury fizjologiczne nieobjęte procesem złośliwym (łącznie 207), zmiany złośliwe (41 guzów, 28 węzłów chłonnych) oraz zmiany łagodne (łącznie 15 obszarów). Badania przeprowadzono w dwóch fazach: początkowej -60min i opóźnionej -90 minut po dożylnej iniekcji radiofarmaceutyku 18 F-FDG. Analiza obejmowała porównanie średniej i maksymalnej standaryzowanej wartości wychwytu SUV: SUVmax, SUVmean oraz jej procentowe zmiany w obu fazach badania. Zmiany o charakterze łagodnym wykazały spadek wychwytu glukozy w czasie, a obszary złośliwe wyraźny wzrost aktywności metabolicznej. AbstractThe aim of this study was to evaluate the usefulness of dual time point (DTP) examinations with

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Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma

Cited by 31 publications

References 18 publications

The Clinical Role of Dual-Time-Point 18F-FDG PET/CT in Differential Diagnosis of the Thyroid Incidentaloma

The Clinical Role of Dual-Time-Point 18F-FDG PET/CT in Differential Diagnosis of the Thyroid Incidentaloma

18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution 18F-FDG-directed surgery experience: feasibility and quantification of 18F-FDG accumulation within 18F-FDG-avid lesions and background tissues

Ocena przydatności badań opóźnionych 18F-FDG PET/CT w różnicowaniu zmian łagodnych i złośliwych

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