2022
DOI: 10.3389/fneur.2022.923142
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Dual vs. mono antiplatelet therapy for acute ischemic stroke or transient ischemic attack with evidence of large artery atherosclerosis

Abstract: Background and purposeCurrent pieces of evidence support the short-term use of dual antiplatelet (DAPT) in minor ischemic stroke or transient ischemic attack (TIA) based on the studies performed in patients with a broad range of non-cardioembolic stroke mechanisms. However, the efficacy and safety of DAPT use in ischemic stroke patients with large artery atherosclerosis (LAA) are still uncertain. We undertook a systemic search and formal meta-analysis to compare DAPT vs. mono-antiplatelet therapy (MAPT) in pat… Show more

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Cited by 6 publications
(3 citation statements)
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“…Despite ongoing debates regarding the safety and efficacy of DAPT in ischemic stroke patients with ICAS, there is currently no consensus on its use ( 4 , 5 , 44 ). Our systematic review, incorporating recent RCTs, shows that DAPT significantly reduced the composite of ischemic and bleeding events, strokes, and cerebral infarctions in these patients.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Despite ongoing debates regarding the safety and efficacy of DAPT in ischemic stroke patients with ICAS, there is currently no consensus on its use ( 4 , 5 , 44 ). Our systematic review, incorporating recent RCTs, shows that DAPT significantly reduced the composite of ischemic and bleeding events, strokes, and cerebral infarctions in these patients.…”
Section: Discussionmentioning
confidence: 99%
“…This systematic review is subject to limitations. Notably, variability in outcomes was observed, influenced by factors such as the ICAS location and severity, timing of DAPT initiation ( 44 , 53 , 54 ), and duration of therapy ( 4 , 5 , 44 ). These heterogeneities could impact our findings’ reliability, yet they not accounted for in our meta-analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Asians have a higher risk of ischemic stroke secondary to intracranial atherosclerosis when compared to Caucasians, [ 2 ]. Several ongoing trials such as CHANCE-2 and CAPTIVA have attempted to elucidate the optimal medical management for stroke patients with intracranial atherosclerosis mechanism [ 3 , 4 ]. Despite undergoing medical management, patients with intracranial atherosclerosis remain at a higher risk for recurrent ischemic strokes [ 5 ].…”
Section: Introductionmentioning
confidence: 99%