Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors

Sun, Xin; Han, Shan; Lin, Qibo; Chen, Ziyan; Li, Dongxu; Liu, Zhankai; Peng, Ke; Chen, Zeyu

doi:10.3390/mi13060946

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Thus, PACT serves as a camera that reveals the light energy distribution in deep tissue by perceiving the distribution of light absorption ( 33 ). Here, we incorporated our AH-VIEW device into a home-built PACT system ( 34 ) to establish an AH-VIEW–enhanced PACT system (AH-VIEW-PACT), as illustrated in fig. S4A, to investigate the changes in the spatial distribution of optical energy under AH-VIEW by reconstructing the optical absorption distribution.…”

Section: Resultsmentioning

confidence: 99%

Acoustic hologram–induced virtual in vivo enhanced waveguide (AH-VIEW)

Lin,

Li,

Wang

et al. 2024

Sci. Adv.

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Optical imaging and phototherapy in deep tissues face notable challenges due to light scattering. We use encoded acoustic holograms to generate three-dimensional acoustic fields within the target medium, enabling instantaneous and robust modulation of the volumetric refractive index, thereby noninvasively controlling the trajectory of light. Through this approach, we achieved a remarkable 24.3% increase in tissue heating rate in vitro photothermal effect tests on porcine skin. In vivo photoacoustic imaging of mouse brain vasculature exhibits an improved signal-to-noise ratio through the intact scalp and skull. These findings demonstrate that our strategy can effectively suppress light scattering in complex biological tissues by inducing low-angle scattering, achieving an effective depth reaching the millimeter scale. The versatility of this strategy extends its potential applications to neuroscience, lithography, and additive manufacturing.

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Section: Resultsmentioning

confidence: 99%

Acoustic hologram–induced virtual in vivo enhanced waveguide (AH-VIEW)

Lin,

Li,

Wang

et al. 2024

Sci. Adv.

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“…In our previous work, we reported a ring-array-based PACT system [ 32 ]. Based on this, we further enhanced the laser coupling efficiency and improved the imaging algorithms, resulting in our new system with faster imaging speed and higher imaging resolution.…”

Section: Methodsmentioning

confidence: 99%

Indocyanine Green-Loaded Liposomes-Assisted Photoacoustic Computed Tomography for Evaluating In Vivo Tumor Penetration of Liposomal Nanocarriers

Wu,

Sun,

Liu

et al. 2023

Micromachines

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Liposomes possess the potential to enhance drug solubility, prolong the duration of circulation, and augment drug accumulation at the tumor site through passive and active targeting strategies. However, there is a lack of studies examining the in vivo tumor penetration capabilities of liposomes of varying sizes, which hampers the development of drug delivery systems utilizing liposomal nanocarriers. Here, we present an indocyanine green (ICG)-loaded liposomes-assisted photoacoustic computed tomography (PACT) for directly evaluating the tumor penetration ability of liposomal nanocarriers in vivo. Through the utilization of microfluidic mixing combined with extrusion techniques, we successfully prepare liposomes encapsulating ICG in both large (192.6 ± 8.0 nm) and small (61.9 ± 0.6 nm) sizes. Subsequently, we designed a dual-wavelength PACT system to directly monitor the in vivo tumor penetration of large- and small-size ICG-encapsulated liposomes. In vivo PACT experiments indicate that ICG-loaded liposomes of smaller size exhibit enhanced penetration capability within tumor tissues. Our work presents a valuable approach to directly assess the penetration ability of liposomal nanocarriers in vivo, thereby facilitating the advancement of drug delivery systems with enhanced tumor penetration and therapeutic efficacy.

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The influences of finite aperture size in photoacoustic computed tomography

Luo,

Jiang,

et al. 2023

Ultrasonics

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Dual-Wavelength Photoacoustic Computed Tomography with Piezoelectric Ring-Array Transducer for Imaging of Indocyanine Green Liposomes Aggregation in Tumors

Cited by 3 publications

References 31 publications

Acoustic hologram–induced virtual in vivo enhanced waveguide (AH-VIEW)

Acoustic hologram–induced virtual in vivo enhanced waveguide (AH-VIEW)

Indocyanine Green-Loaded Liposomes-Assisted Photoacoustic Computed Tomography for Evaluating In Vivo Tumor Penetration of Liposomal Nanocarriers

The influences of finite aperture size in photoacoustic computed tomography

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