Dual α2-Adrenergic Agonist and α1-Adrenergic Antagonist Actions of Dexmedetomidine on Human Isolated Endothelium-Denuded Gastroepiploic Arteries

Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery

“…Several studies have shown that HR decreases after DEX injection, which may or may not be associated with a transitory increase in MBP [5,17,[42][43][44]. The decrease in HR is dose-dependent and is probably due to baroreflex activation [18], and slow drug infusion tends to minimize this.…”

Dexmedetomidine Combined with General Anesthesia Provides Similar Intraoperative Stress Response Reduction When Compared with a Combined General and Epidural Anesthetic Technique

“…Several studies have shown that HR decreases after dexmedetomidine injection, which may or may not be associated with a transitory increase in MAP. [34][35][36] A moderate dose of dexmedetomidine was used in this study so as to avoid the side effects usually associated with higher infusion rates, including bradycardia, hypotension, and/or hypertension. Study patients anesthetized with dexmedetomidine did not experience any episodes of bradycardia during surgery.…”

Vascular reactivity in human arteries: from experimental study to clinical application

“…The range of cardiovascular effects reported to be exerted by DEX may reflect the physiological consequences of activation of peripheral or central a 2 -adrenergic receptors. We have demonstrated that DEX has little direct effect on the smooth muscle in human resistance arteries at the steady-state plasma concentrations normally achieved in clinical practice (i.e., \10 -7 M), but that higher concentrations of DEX have dual a 2 -agonist and a 1 -adrenergic antagonist actions [26].…”