2003
DOI: 10.1051/medsci/200319111101
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Dualité fonctionnelle des récepteurs des kinines en physiopathologie

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Cited by 9 publications
(3 citation statements)
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“…The aminopeptidases, carboxypeptidases, neutral endopeptidase and angiotensin converting enzyme (also known as kininase II) are the main enzymes responsible for the metabolism of bradykinin (BK) and kallidin (Lys‐BK) into active and inactive peptide fragments. These enzymes ensure that the half‐life of kinins is only a few seconds (Décarie et al, ; Gabra et al, ). Kinins exert their biological effects by activating two GPCRs: the bradykinin B 1 receptor and B 2 receptor (Regoli et al, ; Leeb‐Lundberg et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…The aminopeptidases, carboxypeptidases, neutral endopeptidase and angiotensin converting enzyme (also known as kininase II) are the main enzymes responsible for the metabolism of bradykinin (BK) and kallidin (Lys‐BK) into active and inactive peptide fragments. These enzymes ensure that the half‐life of kinins is only a few seconds (Décarie et al, ; Gabra et al, ). Kinins exert their biological effects by activating two GPCRs: the bradykinin B 1 receptor and B 2 receptor (Regoli et al, ; Leeb‐Lundberg et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…La production de certaines cytokines inflammatoires, telles que l'Il-6 dans les cellules glandulaires prostatiques [6], permettra aussi de moduler la voie d'expression du PSA [12,38]. Enfin, le PSA, en tant que kallikréine, est impliqué dans la réaction inflammatoire incitant la production des facteurs d'inflammation [8].…”
Section: Discussionunclassified
“…Thus, inhibition of the angiotensin-converting enzyme by ACE inhibitors results in reduced levels of Ang II, which is also coupled to increased levels of bradykinin, a vasodilator which exerts its effects through binding to the B2 receptor. The B2 receptor is coupled to G -proteins and the effects of bradykinin are through the GPCR signalling pathway [ 123 , 124 ]. This demonstrates the crucial role played by the angiotensin converting enzyme and the B2 receptor in regulating BP.…”
Section: Literature Reviewmentioning
confidence: 99%