Partially motivated by the fact that the grand partition function of the ABJM theory or its generalization is expressed by a spectral operator enjoying symmetries of the Weyl group, it was found that the grand partition function satisfies the q-Painlevé equation, which is constructed from the affine Weyl group. In this paper we clarify the affine symmetries of the grand partition function. With the affine symmetries, we find that the grand partition function extends naturally outside the fundamental domain of duality cascades and once the Painlevé equation holds in the fundamental domain, so does it outside.