Dually crosslinked injectable hydrogels of poly(ethylene glycol) and poly[(2-dimethylamino)ethyl methacrylate]-b-poly(N-isopropyl acrylamide) as a wound healing promoter

Kannan, Deepika; Nutan, Bhingaradiya; Singh, Shailja; Jewrajka, Suresh K.

doi:10.1039/c7tb00848a

Cited by 42 publications

(66 citation statements)

References 51 publications

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“…This is a dynamic process, taking approximately 10 min under controlled conditions of temperature (25 °C) and atmospheric pressure. The SEM images of the gel formed in the representative DMSO/water system show physically cross-linked 3D fibrous networks ( Figure 7 J–L), 61 , 62 whereas AFM images ( Figure 7 M–O) show the formation of short sponge-like fibers. 63 As shown in AFM images of the organogels ( Figure 7 M–O), bundles of fibers are linked through physical interactions.…”

Section: Resultsmentioning

confidence: 99%

Concentration- and Temperature-Responsive Reversible Transition in Amide-Functionalized Surface-Active Ionic Liquids: Micelles to Vesicles to Organogel

et al. 2020

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A ubiquitous example of DNA and proteins inspires the scientific community to design synthetic systems that can construct various self-assembled complex nano-objects for high-end physiological functions. To gain insight into judiciously designed artificial amphiphilic structures that through self-assembling form various morphological architectures within a single system, herein, we have studied self-aggregation of amide-functionalized surface-active ionic liquids (AFSAILs) with different head groups in the DMSO/water mixed system. The AFSAIL forms stimuli-responsive reversible micelle and vesicle configurations that coexist with three-dimensional (3D) network structures, the organogel in the DMSO/water mixed system. The self-assembly driving forces, self-organization patterns, network morphologies, and mechanical properties of these network structures have been investigated. With the proven biodegradability and biocompatibility, one can envisage these AFSAILs as the molecules with a new dimension of versatility.

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Section: Resultsmentioning

confidence: 99%

Concentration- and Temperature-Responsive Reversible Transition in Amide-Functionalized Surface-Active Ionic Liquids: Micelles to Vesicles to Organogel

et al. 2020

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“…The current article deals with the reaction of the bifunctional coupler (piperazine‐bearing aminochlorohydrin and azetidinium group) with bromohexadecane followed by N,N′ ‐dimethylaminoethyl methacrylate (DMAEMA) to produce piperazine‐methacrylate monomer and its homopolymer using free‐radical polymerization process. The DMAEMA was chosen due to its wide applications in the production of biodegradable packaging, hydrogels, wound dressing materials to control moisture in and around the infected area, and drug delivery systems due to its low toxicity …”

Section: Introductionmentioning

confidence: 99%

Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms

Jalageri

Puttaiahgowda

Parambil

et al. 2019

J of Applied Polymer Sci

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The study intends to design a simple and powerful synthesis of piperazine‐methacrylate monomer and its homopolymer. The synthesized piperazine‐methacrylate monomer was polymerized by solution polymerization technique in the presence of free‐radical initiator azobis(2‐methylpropionitrile) resulting in the formation of multifunctionalized piperazine polymer. The structural investigation was done by FTIR and NMR (1H and 13C NMR). The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature (Tg) at 88.4 °C. The polymer surface was found to be soft and nonporous which was examined by FESEM. The synthesized polymeric compound exhibited good antimicrobial activity against Gram‐negative bacterium Escherichia coli, tubercular variant Mycobacterium smegmatis, and Gram‐positive bacterium Staphylococcus aureus with a zone of inhibition at a range of 15.60–19.33, 15.33–17, and 15.67–18 mm diameter, respectively. The polymer also showed good activity against fungus Candida albicans with a zone of inhibition at a range of 16.33–22 mm diameter. The percentage inhibition of microorganisms increased with increase in concentration (1.5–12 mg) which is carried out by optical density method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47521.

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“…Hydrogel dressings can be developed for specific wounds based on their size, severity, and location. In addition, these dressings can be easily applied to irregular or deep wounds due to their ability to induce in situ and cytocompatible chemical crosslinking [ 45 , 46 , 47 , 48 ]. In the next section, we review functional hydrogels for chronic wound healing.…”

Section: Chronic Woundsmentioning

confidence: 99%

Functional Hydrogels for Treatment of Chronic Wounds

Firlar

Altunbek

McCarthy

et al. 2022

Gels

107

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Chronic wounds severely affect 1–2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.

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Dually crosslinked injectable hydrogels of poly(ethylene glycol) and poly[(2-dimethylamino)ethyl methacrylate]-b-poly(N-isopropyl acrylamide) as a wound healing promoter

Abstract: PEG-based dually crosslinked injectable hydrogels have been developed through extremely simple chemistry which avoids use of small molecular weight crosslinker, formation of by-products and involved low heat change. The hydrogels are useful for wound healing and soft tissue regeneration.

Cited by 42 publications

References 51 publications

Concentration- and Temperature-Responsive Reversible Transition in Amide-Functionalized Surface-Active Ionic Liquids: Micelles to Vesicles to Organogel

Concentration- and Temperature-Responsive Reversible Transition in Amide-Functionalized Surface-Active Ionic Liquids: Micelles to Vesicles to Organogel

Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms

Functional Hydrogels for Treatment of Chronic Wounds

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