Dually enhanced phototherapy by gambogic acid and hyperthemia-activated chemotherapy for synergistic breast cancer treatment

Wang, Yuhan; Yue, Chunyan; Zhang, Mengyao; Li, Dazhao; Xu, Tao; He, Mengying; Wang, Mengyuan; Zhao, Yong; Ni, Zihui; Zhi, Feng; Hu, Yiqiao; Ding, Dawei

doi:10.1016/j.cej.2022.139108

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…GA has been demonstrated to intervene in the intrinsic protective mechanisms of tumor cells, thereby reducing their tolerance to high temperatures. [ 83 ] Tang et al have synthesized COF‐GA and conducted a series of cellular and animal experiments. [ 84 ] In cellular experiments, the cell survival rate of COF‐GA after laser treatment (30%) was significantly lower than that of COF cells after laser treatment (60%) (Figure 4d).…”

Section: Biological Applications Of Cofs In Anticancermentioning

confidence: 99%

The Cutting‐Edge Progress in Covalent Organic Framework‐Based Nanomedicine

Guo,

Liu,

Fang

et al. 2024

Advanced NanoBiomed Research

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Covalent organic frameworks (COFs) are a class of porous crystalline materials with exceptional properties, constructed through covalently linked organic units. COFs are extensively applied in the field of biomedicine, particularly in the context of anticancer treatments. First, this review summarizes the diverse synthetic methods of COFs, including solvothermal synthesis, microwave‐assisted synthesis, room temperature synthesis, interface synthesis, ionothermal techniques, mechanical grinding, and electrochemical methods, and their impacts on the material's structure and performance. Second, COFs exhibit tremendous potential in the field of cancer therapy because of their orderly lattice structure, tunable pore sizes, high surface area, and excellent thermal and chemical stability. Therefore, the article deeply explores the applications of COFs in diverse cancer treatment modalities, encompassing early diagnostic bioimaging, drug delivery, various phototherapies, chemodynamic therapy, sonodynamic therapy, radiation therapy, and their combined therapeutic strategies. Finally, the article points out current research challenges and future directions in this field.

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Section: Biological Applications Of Cofs In Anticancermentioning

confidence: 99%

The Cutting‐Edge Progress in Covalent Organic Framework‐Based Nanomedicine

Guo,

Liu,

Fang

et al. 2024

Advanced NanoBiomed Research

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“…To this end, this novel nanosystem showed great potential in concurrently overcoming serious challenges by advancing the effectiveness of synergistic photo/chemo/photodynamic therapies. 98 …”

Section: Gambogic Acid Nano-delivery Using Nano-particulatesmentioning

confidence: 99%

Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy

Fahmy,

Elghanam,

Rashid

et al. 2024

RSC Adv.

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“…Using an ultrasonication process, Wang et al combined the chemo drug paclitaxel (PTX), IR-780, and GA to prepare PTX-IR780-GA for PTT/PDT/chemotherapy of breast cancer ( Figure 5 ) [ 118 ]. Using 1-hexadecanol and oleic acid, they prepared a thermoresponsive phase-change material with a melting point of 46 °C, that can be used to control the drug release triggered by hyperthermia.…”

Section: Downregulation Of Hsp90/hsp70 Through a Nanomaterial-based A...mentioning

confidence: 99%

“… Dually enhanced phototherapy by gambogic acid and hyperthermia-activated chemotherapy for synergistic breast cancer treatment. Reprinted with permission from [ 118 ]. Copyright 2023, Elsevier B.V. …”

Section: Figurementioning

confidence: 99%

Functionalized Nanomaterials for Inhibiting ATP-Dependent Heat Shock Proteins in Cancer Photothermal/Photodynamic Therapy and Combination Therapy

Premji,

Dash,

Das

et al. 2024

Nanomaterials

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Phototherapies induced by photoactive nanomaterials have inspired and accentuated the importance of nanomedicine in cancer therapy in recent years. During these light-activated cancer therapies, a nanoagent can produce heat and cytotoxic reactive oxygen species by absorption of light energy for photothermal therapy (PTT) and photodynamic therapy (PDT). However, PTT is limited by the self-protective nature of cells, with upregulated production of heat shock proteins (HSP) under mild hyperthermia, which also influences PDT. To reduce HSP production in cancer cells and to enhance PTT/PDT, small HSP inhibitors that can competitively bind at the ATP-binding site of an HSP could be employed. Alternatively, reducing intracellular glucose concentration can also decrease ATP production from the metabolic pathways and downregulate HSP production from glucose deprivation. Other than reversing the thermal resistance of cancer cells for mild-temperature PTT, an HSP inhibitor can also be integrated into functionalized nanomaterials to alleviate tumor hypoxia and enhance the efficacy of PDT. Furthermore, the co-delivery of a small-molecule drug for direct HSP inhibition and a chemotherapeutic drug can integrate enhanced PTT/PDT with chemotherapy (CT). On the other hand, delivering a glucose-deprivation agent like glucose oxidase (GOx) can indirectly inhibit HSP and boost the efficacy of PTT/PDT while combining these therapies with cancer starvation therapy (ST). In this review, we intend to discuss different nanomaterial-based approaches that can inhibit HSP production via ATP regulation and their uses in PTT/PDT and cancer combination therapy such as CT and ST.

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Dually enhanced phototherapy by gambogic acid and hyperthemia-activated chemotherapy for synergistic breast cancer treatment

Cited by 9 publications

References 54 publications

The Cutting‐Edge Progress in Covalent Organic Framework‐Based Nanomedicine

The Cutting‐Edge Progress in Covalent Organic Framework‐Based Nanomedicine

Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy

Functionalized Nanomaterials for Inhibiting ATP-Dependent Heat Shock Proteins in Cancer Photothermal/Photodynamic Therapy and Combination Therapy

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