Dually targeted bioinspired nanovesicle delays advanced prostate cancer tumour growth in vivo

Ma, Guanglong; Severic, Maja; Barker, Matthew; Pereira, Sara; Ruiz, Amalia; Cheung, Calvin; Al-Jamal, Wafa' T

doi:10.1016/j.actbio.2021.07.021

Cited by 9 publications

(4 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bioinspired nanovesicles include biomimetics and cell-derived nanovesicles, which form a new class of drug delivery carriers ( Goh et al, 2017 ; Zhao et al, 2020 ). The construction of these vesicles involves extrusion of intact cells and then synthesis of nanoparticles with a coating of cell-derived membranes and fusing exosomes with lipid-derived particles ( Ma et al, 2021 ). This ensures a high loading capability and mimics many natural particles so that it may not evoke any type of immune response.…”

Section: Bioinspired Nanovesiclementioning

confidence: 99%

“… Ma et al (2021) simultaneously targeted two specific components of prostate cancer (PC). In PC, prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) are found to be highly upregulated in advanced stages of PC, and there was no evidence that they are both targeted.…”

Section: Bioinspired Nanovesiclementioning

confidence: 99%

“…Finally, they are also highly biocompatible, finding application in drug delivery, immunotherapy, tumor targeting, and gene delivery (Ilahibaks et al, 2019;Park et al, 2019). Ma et al (2021) simultaneously targeted two specific components of prostate cancer (PC). In PC, prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) are found to be highly upregulated in advanced stages of PC, and there was no evidence that they are both targeted.…”

Section: Bioinspired Nanovesicle Nanovesiclesmentioning

confidence: 99%

See 2 more Smart Citations

Recent advancement of bioinspired nanomaterials and their applications: A review

Wu¹,

Hui²,

Hu³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

With the advancement in the field of nanotechnology, different approaches for the synthesis of nanomaterials have been formulated, among which the bioinspired or biomimetic nanoplatforms have been utilized for different biomedical applications. In this context, bioinspired or biomimetic nanoparticles (NPs) have been synthesized in which the inspiration for synthesis is taken from nature or its components. Innovations in bioengineering tools and bio-conjugation chemistry have enabled scientists to develop novel types of such nanoplatforms. They have several advantages over normal synthesis protocols. In this review, we 1) summarized nanomaterial types and their advancements in bioinspired nanotechnology therapies; 2) discussed the major types, novel preparation methods, and synthesis progress of NPs in current biomedical fields; 3) gave a brief account of the need for synthesizing NPs via a bioinspired route rather than their common route; 4) highlighted the updated information on the biomimetic synthesis of different types of NPs; and 5) provided future perspectives in the synthesis of novel NPs for their potential applications in biomedical sciences.

show abstract

Section: Bioinspired Nanovesiclementioning

confidence: 99%

Section: Bioinspired Nanovesiclementioning

confidence: 99%

Section: Bioinspired Nanovesicle Nanovesiclesmentioning

confidence: 99%

See 1 more Smart Citation

Recent advancement of bioinspired nanomaterials and their applications: A review

Wu¹,

Hui²,

Hu³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Recently, cell‐derived nanosized vesicles “bioinspired soft nanovesicles” such as exosomes, extracellular vesicles, cell ghosts structures, and so forth have been proposed as versatile carriers of therapeutic biomolecules (Gurunathan et al, 2019; I. K. Herrmann et al, 2021; Kalluri & LeBleu, 2020; Ma et al, 2021; Pozzi et al, 2014; Singaravelu et al, 2020). These systems are excellent therapeutic candidates due to high biocompatibility, easy preparation, inherent targeting surface markers, specific bio‐distribution and selective targeting ability, and improved stability (Abello et al, 2019; Betzer et al, 2020; I. K. Herrmann et al, 2021; Malhotra et al, 2019; Parodi et al, 2013; Raposo & Stahl, 2019).…”

Section: Introductionmentioning

confidence: 99%

Bioinspired soft nanovesicles for site‐selective cancer imaging and targeted therapies

Prasad

Conde

2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Cell-to-cell communication within the heterogeneous solid tumor environment plays a significant role in the uncontrolled metastasis of cancer. To inhibit the metastasis and growth of cancer cells, various chemically designed and biologically derived nanosized biomaterials have been applied for targeted cancer therapeutics applications. Over the years, bioinspired soft nanovesicles have gained tremendous attention for targeted cancer therapeutics due to their easy binding with tumor microenvironment, natural targeting ability, bioresponsive nature, better biocompatibility, high cargo capacity for multiple therapeutics agents, and long circulation time. These cell-derived nanovesicles guard their loaded cargo molecules from immune clearance and make them site-selective to cancer cells due to their natural binding and delivery abilities. Furthermore, bioinspired soft nanovesicles prevent cell-to-cell communication and secretion of cancer cell markers by delivering the therapeutics agents predominantly. Cell-derived vesicles, namely, exosomes, extracellular vesicles, and so forth have been recognized as versatile carriers for therapeutic biomolecules. However, low product yield, poor reproducibility, and uncontrolled particle size distribution have remained as major challenges of these soft nanovesicles. Furthermore, the surface biomarkers and molecular contents of these vesicles change with respect to the stage of disease and types. Here in this review, we have discussed numerous examples of bioinspired soft vesicles for targeted imaging and cancer therapeutic applications with their advantages and limitations. Importance of bioengineered soft nanovesicles for localized therapies with their clinical relevance has also been addressed in this article. Overall, cell-derived nanovesicles could be considered as clinically relevant platforms for cancer therapeutics.

show abstract

Co-delivery of Anticancer Drugs Using Polymer-Based Nanomedicines for Lung and Prostate Cancer Therapy

Peter,

Naki,

Alven

et al. 2023

Interaction of Nanomaterials With Living Cells

View full text Add to dashboard Cite

Dually targeted bioinspired nanovesicle delays advanced prostate cancer tumour growth in vivo

Cited by 9 publications

References 59 publications

Recent advancement of bioinspired nanomaterials and their applications: A review

Recent advancement of bioinspired nanomaterials and their applications: A review

Bioinspired soft nanovesicles for site‐selective cancer imaging and targeted therapies

Co-delivery of Anticancer Drugs Using Polymer-Based Nanomedicines for Lung and Prostate Cancer Therapy

Contact Info

Product

Resources

About