Duan-Nai-An, A Yeast Probiotic, Improves Intestinal Mucosa Integrity and Immune Function in Weaned Piglets

Zhaxi, Yingpai; Meng, Xiaoqin; Wang, Wenhui; Wang, Ling; He, Zhuolin; Zhang, Xintong; Pu, Wanxia

doi:10.1038/s41598-020-61279-6

Cited by 28 publications

(23 citation statements)

References 48 publications

(35 reference statements)

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“…The starter feed is very crucial to a successful transition and the taste is important to piglets. They have to like what they are eating to continue to return to the feeder [15]. From our results of daily weight gain, daily food consumption, and feed conversion rate, additions of Totipro or/and PF1001 do not affect the daily food consumption significantly, while the daily weight gain is actually increased comparing to the control and antibiotic groups.…”

Section: Discussionmentioning

confidence: 69%

The Postbiotics, Totipro PE0401, and Probiotic Mixture, PF1001, Modulate the Gut Microbiota and Ameliorate Diarrhea in Weaning Piglets

Ho¹

2020

BJSTR

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Pigs are a popular form of livestock, with high economic values in food, clothing, cosmetics, and medical industries. More than one billion pigs butchered each year worldwide, and the main consuming countries are in Asia as dietary food source. The weaning stage is considered one of the most critical periods in swine production, where piglet performance can be seriously affected and where they are predisposed to the overgrowth of opportunistic pathogens [1]. Piglet diarrhea or "scour" can be common at both the neonatal and the post-weaning stages. It is a common cause of mortality and is often closely associated with poor hygiene, inappropriate husbandry (e.g., early weaning), stressful environment and inappropriate feeding factors. Poor hygiene can lead to overgrowth of pathogenic bacteria in the environment. Escherichia coli (E. coli) strains are common within the first week of life, and again in the first week after weaning. The weaning process increases the stress on piglets, and thus their susceptibility to viral and bacterial infections. Diarrhea in these older piglets tends to be less severe, and mortality rates lower than in pre-weaning piglets. Potential sources of diarrhea at this stage include E. coli, Rotavirus, TGE (Transmissible gastroenteritis), salmonellosis, Campylobacter and Brachyspira hyodysenteriae [2]. Therefore, uses of antibiotics or medications are almost inevitable during the weaning process in the past. However, due to the increasing problem of drug resistance of bacteria, the use of antibiotic growth promoters for prevention of diarrheal diseases in piglets has been banned since 2006 [3]. Coincidentally, due to the concern of environmental and food safety, the use of medicinal zinc oxide (ZnO) must be phased out by 2022 [4]. Thus, alternative strategies are urgent needs to prevent diarrhea and promote the health in weaner piglets. Various natural

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Section: Discussionmentioning

confidence: 69%

The Postbiotics, Totipro PE0401, and Probiotic Mixture, PF1001, Modulate the Gut Microbiota and Ameliorate Diarrhea in Weaning Piglets

Ho¹

2020

BJSTR

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“…improve ADG and feed utilization of piglets (16)(17)(18). Yeast culture stimulated intestinal fermentation, increased the yield of volatile fatty acids and the products of bacterial fermentation, and provided some energy for pigs to improve nutrient utilization (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Yucca Schidigera Extract and Oral Candida utilis on Growth Performance and Intestinal Health of Weaned Piglets

Yang

Wang

et al. 2021

Front. Nutr.

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Weaning piglets experienced the transformation from breast milk to solid feed and present the proliferation of pathogens, the presence of diarrhea, poor growth performance and even death. Plant extracts and probiotics have certain potential in improving animal growth performance, antioxidant capacity and immune function. The purpose of this study was to explore the effects of dietary yucca schidigera extract (YSE) and oral Candida utilis (CU) on growth performance and intestinal health weaned piglets. According to a 2 × 2 factorial design with the main factors being CU (orally administered 1 mL of 0.85% saline with or without CU; fed basal diet with or without 120 mg/kg YSE), forty 28 d healthy weaned piglets were randomly allocated into four groups of 10 barrows each: (1) piglets fed basal diet and orally administered 1 mL of 0.85% saline (CON); (2) piglets fed basal diet and orally administered 1 mL 1 × 109 cfu/mL C. utilis in 0.85% saline (CU); (3) piglets fed the basal diet containing YSE (120 mg/kg) and orally administered 1 mL of 0.85% saline (YSE); (4) Piglets fed the basal diet containing 120 mg/kg YSE and 1 mL 1 × 109 cfu/mL C. utilis in 0.85% saline (YSE+CU). This study lasted 28 days and evaluated the effects of dietary YSE and oral CU on growth performance, immunity, antioxidant function, ileal morphology, and intestinal microflora in weaned piglets. Dietary YSE increased ADG, the spleen and lymph node indexes, serum GLU, BUN, T-SOD, T-AOC, CAT concentrations, ileal villus height and villus height/crypt depth, jejunal occludin, and β-definsin-2 concentrations and ileal occludin concentration in weaned piglets (P < 0.05); decreased the diarrhea rate and mortality, rectal pH and urine pH, the BUN and MDA concentrations, crypt depth (P < 0.05); improved the diversity of cecal microflora. Orally CU increased ADG, and ADFI, the T-SOD, T-AOC, and CAT activity, ileal villus height, villus height/crypt depth, jejunum occludin, and β-definsin-2 concentrations (P < 0.05); reduced the diarrhea rate and mortality, urine pH, the BUN and MDA concentrations, crypt depth (P < 0.05); improved the diversity of cecal microflora. Dietary YSE and orally CU increased the T-SOD, T-AOC, and CAT activity, villus height/crypt depth, jejunal occludin concentration; reduced the diarrhea rate of weaned piglets by 28%, gastric pH, ileal pH, cecal pH and urine pH, MDA, crypt depth; improved the diversity of cecal microflora. YSE and CU could improve the growth performance, reduce the diarrhea rate, improve intestinal health, and increase the diversity and abundance of cecal microflora in weaned piglets and expected to be used as antibiotics alternative feed additives in the production of weaned piglets.

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“…Shen et al [13] showed that yeast culture could signi cantly increase the feed intake of piglets. In addition, the researches on piglets and growing-nishing pigs showed that yeast culture could improve the daily gain and feed utilization rate of piglets [14][15][16] . It may be that yeast culture stimulated intestinal fermentation, increased the yield of volatile fatty acids and the end products of bacterial fermentation, and provided some energy for pigs to improve nutrient utilization [17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

Effects of Yucca Shidigera Extract and Candida Utilis on Growth Performance and Intestinal Health of Weaned Piglets

Yang¹,

Wang²,

He³

et al. 2020

Preprint

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BackgroundEconomic benefit is an important goal pursued by animal husbandry industry. The emergence of antibiotics has promoted the development of animal husbandry, but many problems caused by the abuse of antibiotics have caused concerns about the use of antibiotics from all walks of life. Therefore, it is imperative to find alternatives to antibiotics. A large number of studies have shown that plant extracts and probiotics have certain potential in improving animal growth performance, antioxidant capacity and immune function. The purpose of this study was to explore the effects of Yucca Shidigera Extract (YSE) and Candida Utilis (CU) on weaned piglets. We compared and evaluated the effects of YSE and CU on weaned piglets from the aspects of growth performance, immunity, antioxidant function, ileal morphology and microflora changes. Forty 28-day-old healthy weaned piglets (Rongchang pig×Landrace×Large white) were randomly divided into 4 treatments: (1) control group (CON); (2) CU; (3) YSE; (4) CU+YSE. ResultsOur results showed that YSE and CU improved the growth performance by significantly increasing final weight, average daily gain (ADG) (P < 0.05), and there is decreasing trend of feed/gain ratio (P=0.087). The effect of adding YSE or CU alone on growth performance had little difference, and the effect of oral CU was slightly better than that of adding YSE. At the same time, the combination of YSE and CU had a good effect on reducing the diarrhea rate. In addition, both YSE and CU increased the diversity of cecal microflora, and CU increased the diversity more significantly, but did not change the dominant microflora of cecum. We also found that the addition of YSE and CU could maintain the structural integrity of intestinal tissue and regulate intestinal pH, to maintain the level of intestinal-associated immune proteins. At the same time, YSE and CU have certain benefits in regulating intestinal flora. ConclusionYSE and CU can improve the growth performance, reduce the diarrhea rate, improve intestinal health, and increase the diversity and abundance of cecal microflora in weaned piglets. Therefore, they are expected to be used as probiotics in the production of weaned piglets.

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Duan-Nai-An, A Yeast Probiotic, Improves Intestinal Mucosa Integrity and Immune Function in Weaned Piglets

Cited by 28 publications

References 48 publications

The Postbiotics, Totipro PE0401, and Probiotic Mixture, PF1001, Modulate the Gut Microbiota and Ameliorate Diarrhea in Weaning Piglets

The Postbiotics, Totipro PE0401, and Probiotic Mixture, PF1001, Modulate the Gut Microbiota and Ameliorate Diarrhea in Weaning Piglets

Effects of Dietary Yucca Schidigera Extract and Oral Candida utilis on Growth Performance and Intestinal Health of Weaned Piglets

Effects of Yucca Shidigera Extract and Candida Utilis on Growth Performance and Intestinal Health of Weaned Piglets

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