Ductal and lobular carcinoma in situ arising within an enlarging biopsy proven fibroadenoma

Feliciano, Yara; Freire, Rochelle; Net, Jose; Yepes, Monica M.

doi:10.1136/bcr-2020-237017

Cited by 8 publications

(19 citation statements)

References 26 publications

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“…Fibroadenoma (FA) is one of the most common benign breast tumors with a peak age of onset between 15 and 35 years [ 1 ]. Breast cancer rarely arises from FA and is detected only in 0.02–0.125% of FA-related cases, usually in patients over 40 years of age [ 2 ]. Furthermore, clinical, sonographic and mammographic findings are similar to those of FA alone [ 3 ], thereby complicating cancer detection.…”

Section: Introductionmentioning

confidence: 99%

Early HER2-positive breast cancer arising from a fibroadenoma: a case report

Fujimoto

Matsuura

Kawasaki

et al. 2021

Oxford Medical Case Reports

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Breast cancer arising from fibroadenoma (FA) is rare, in which almost all reported cases are human epidermal growth factor receptor 2 (HER2)-negative. This is the first report to describe a case of HER2-positive breast cancer arising from FA that was treated with chemotherapy plus anti-HER2 therapy. In this early case, upfront surgery outcomes guided the selection of appropriate systemic therapy. A 31-year-old woman previously diagnosed with FA experienced tumor growth. Core needle biopsy and imaging studies confirmed a diagnosis of stage IIA HER2-positive invasive ductal carcinoma (IDC) with no evidence of lymph node metastasis (cT2N0M0). Breast-conserving surgery was performed. Pathological diagnosis revealed stage IA IDC with a predominant intraductal component (pT1aN0M0), arising from FA. In conclusion, we encountered an extremely rare case of HER2-positive breast cancer arising from FA in which pathological infiltration was difficult to predict based on preoperative imaging.

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Section: Introductionmentioning

confidence: 99%

Early HER2-positive breast cancer arising from a fibroadenoma: a case report

Fujimoto

Matsuura

Kawasaki

et al. 2021

Oxford Medical Case Reports

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“…Cancer may arise from the surrounding breast tissue, in the fissures of the FA, or the carcinoma may be completely confined within the FA. The age at presentation of these patients is 42.5 to 46.9 years-old, approximately 20 years later than the maximum age at presentation of patients with pure FA[ 1 , 6 , 10 , 12 ].…”

Section: Discussionmentioning

confidence: 95%

“…FA is a biphasic tumor composed of stromal (connective) and epithelial tissue that grows by estrogen and progesterone stimulation and is commonly found in pregnancy and lactation. During menopause, FAs suffer atrophy[ 3 , 4 , 6 , 9 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Ductal carcinoma in situ within a fibroadenoma: A case report and review of literature

Olivares-Antúnez,

Dávila-Zablah,

Vázquez-Ávila

et al. 2024

World J Radiol

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BACKGROUND Fibroadenoma (FA) is the most common tumor found in young women, although it can occur in any age group. Ductal carcinoma in situ (DCIS) that is confined in a FA is rare; it is most frequently reported as an incidental finding. CASE SUMMARY We report a case of DCIS within a FA in a 46-year-old female without cancer-related personal and family histories. The patient was diagnosed with a breast conglomerate of nodules and was followed for 1 year. In the current control image study, we found suspicious microcalcification, as a new finding, within one of the nodules. Consequently, a core biopsy of the tumor, which appeared hypoechoic, oval, and circumscribed, was performed. The pathological diagnosis was ductal carcinoma in situ within a fibroepithelial lesion. The patient underwent breast-conserving surgery and received radiotherapy as well as endocrine therapy (tamoxifen). CONCLUSION We recommend a multidisciplinary approach for adequate treatment and follow-up.

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“…These 2 cases of breast DCIS arising within a fibroadenoma also clearly suggest that fibroadenomas should not be ignored and warrant close follow-up. Based on the course of the follow-up and diagnosis in the above cases and referring to the previous literature, a significantly enlarged mammary nodule with irregular morphology or uneven internal echogenicity under ultrasound may indicate the need for biopsy or surgical intervention[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Preoperational diagnosis and management of breast ductal carcinoma in situ arising within fibroadenoma: Two case reports

Wu¹,

Sun²,

Mo³

et al. 2022

WJCC

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BACKGROUND Ductal carcinoma in situ (DCIS) arising within fibroadenoma is a type of tumor that is rarely encountered in clinic, with only about 100 cases of carcinoma arising within a fibroadenoma reported in the literature. Here, we present two cases of breast DCIS arising within a fibroadenoma and discuss their clinical and imaging findings as well as treatment. CASE SUMMARY The patients did not have cancer-related personal and family histories. Case 1 (a 49-year-old woman) was diagnosed with a bilateral breast nodule in May 2018 and was followed (preoperative imaging data including ultrasound and mammography) for 3 years; she underwent an excisional biopsy to address an enlargement in nodule size. Case 2 (a 37-year-old woman) was diagnosed with a left breast nodule in June 2021 and consequently received vacuum-assisted biopsy of the tumor which appeared as “irregularly shaped” and “unevenly textured” tissue on ultrasound. The pathological diagnosis was clear in both cases. Both patients underwent breast-conserving surgery and sentinel lymph node biopsy. The two cases received or planned to receive radiotherapy as well as endocrine therapy (tamoxifen). CONCLUSION Breast DCIS arising within a fibroadenoma is rare, but patients treated with radiotherapy and endocrine therapy can have good prognosis.

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Ductal and lobular carcinoma in situ arising within an enlarging biopsy proven fibroadenoma

Cited by 8 publications

References 26 publications

Early HER2-positive breast cancer arising from a fibroadenoma: a case report

Early HER2-positive breast cancer arising from a fibroadenoma: a case report

Ductal carcinoma in situ within a fibroadenoma: A case report and review of literature

Preoperational diagnosis and management of breast ductal carcinoma in situ arising within fibroadenoma: Two case reports

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