Ductal carcinoma in situ arising in mammary hamartoma

Tse, Gary; Law, Ben M. F.; Pang, L-M; Cheung, Hoiwan

doi:10.1136/jcp.55.7.541

Cited by 27 publications

(18 citation statements)

References 8 publications

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“…Very rarely, it has also been reported that hamartomas develop into carcinoma (7). While an invasive lobular carcinoma is reported to develop in some publications, development of ductal carcinoma is the most frequently reported (15)(16)(17)(18)(19)(20)(21). Thus, once the diagnosis is established, an excision should be performed (Figure 1-3).…”

Section: Discussionmentioning

confidence: 99%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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Objective: Breast hamartomas are benign breast tumors, which are observed very rarely. We aimed to share our surgical approaches and a comparison of preoperative and postoperative pathology results of patients applying to breast polyclinics. Materials and Methods:Out of 32.000 patients approximately, we reviewed data of 12 patients with the diagnosis of breast hamartoma retrospectively, who had applied to the breast polyclinic between dates of March 2007 and October 2012.Results: All patients were female and their average age was 35 (17-58 years). Four of the hamartomas were detected in the right breast, and eight in the left breast. The average diameter of lesions was 7.3 cm (3-21cm). The diameter in our three cases was above 10 cm, and they were evaluated as giant hamartomas. All our cases underwent a fine needle aspiration biopsy (FNAB) or a core biopsy preoperatively. When the reports of preoperative biopsies performed on patients who had applied due to a palpable mass and the postoperative pathology reports were compared, it was detected that they showed a substantial correlation. Conclusion:Hamartomas are benign tumors of the breast. The rate of preoperative diagnosis is high when physical examination, imaging and histopathology approaches are taken in combination. Although very rare, a surgical excision should be performed due to the malignant change in tumors. Hamartomların dördü sağ memede sekizi sol memede saptandı. Lezyonların ortalama çapı 7,3 cm idi (min-maks; 3-21). Üç olguda lezyon çapı 10 cm üzerinde olup bu olgular dev hamartom olarak değerlendirildi. Olgularımı-zın hepsine preoperatif ince iğne aspirasyon biyopsisi (İİAB) veya kor biyopsi yapıldı. Ele gelen kitle ile başvuran hastalara yapılan preoperatif biyopsi ile postoperatif patoloji raporları karşılaştırıldığında büyük oranda korelasyon gösterdikleri tespit edildi.Sonuç: Hamartomlar memenin iyi huylu tümörleridir. Fizik muayene, gö-rüntüleme ve histopatolojinin birlikte ele alınmasıyla preoperatif tanı konma oranı yüksektir. Çok nadir de olsa malign değişim göstermesi sebebiyle cerrahi eksizyon yapılmalıdır.

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Section: Discussionmentioning

confidence: 99%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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“…The unique features of this case include central infarction, skin inflammatory-like reaction, and painful, heavy breast. Sonography and core needle biopsy were characteristically benign, although, malignancy within such a large hamartoma cannot be ruled out as it had been reported [4,5]. Clinically, giant fibroadenoma, lactating adenoma, cystosarcoma phylloides, giant hamartoma, fibrocystic mass, angiosarcoma and inflammatory breast carcinoma are included in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Breast hamartoma is most frequently discovered in the 4th to 6th decade, with a reported age range of 5-76 years [3,4]. This benign tumor may contain coincidental focal epithelial malignancy, including in situ ductal carcinoma, invasive duct carcinoma or invasive lobular carcinoma [4,5]. Inflammatory skin reaction associated with a rapidly enlarging breast mass usually is suspicious for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Although the incidence of hamartoma has been reported to be 0.1-0.7%, the true incidence is believed to be higher due to increasing use of breast imaging and image-guided biopsies. Breast hamartoma is most frequently discovered in the 4th to 6th decade, with a reported age range of 5-76 years [3,4]. This benign tumor may contain coincidental focal epithelial malignancy, including in situ ductal carcinoma, invasive duct carcinoma or invasive lobular carcinoma [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Infarction of a Giant Breast Hamartoma in a Pregnant Patient Mimicking an Inflammatory Breast Cancer

Haj

Chernihovski²,

Solomon³

et al. 2007

Breast Care

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A giant mass of the breast with discoloration of the overlying skin during pregnancy requires investigation to rule out the possibility of breast malignancy. The aim of this paper is to report a case of rapidly growing hamartoma in a pregnant patient mimicking advanced breast cancer and to discuss the usefulness of sonography and core needle biopsy in the diagnosis. Case Report: A 24-year-old woman in her 16th week of pregnancy presented with a very enlarged and painful breast. The overlying skin was edematous, brown to red, with severely dilated and congested veins. A huge mass was palpated and easily separated from the main breast. Results: Sonography and needle core biopsy were consistent with benign lesion but inadequate to exclude malignancy. At surgery, a giant (1,600 g) well-defined, ovoid mass was enucleated under general anesthesia. Gross and microscopic sections of this tumor were consistent with hamartoma with a central area of infarction. Clinical and histological features of this tumor are briefly discussed. Conclusion: Inability to exclude malignancy in case of symptomatic giant breast tumor during pregnancy should be an indication for early surgical excision.

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“…It shows a well-defined lesion of homogeneous hyposignal T1 that enhances homogeneously after injection of contrast medium with a non-enhanced peripheral border [16]. Biopsy or excision with histological examination is not necessary for the diagnosis [8], but allows to affirm the benignity because rare cases of carcinomatous degeneration have been reported [3] [8].…”

Section: Discussionmentioning

confidence: 99%

Giant Breast Hamartoma: A Case Report in Togo

N’timon¹,

Darré²,

Dagbe³

et al. 2018

OJRad

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We report the case of a 50-year-old patient, who was explored in mammography, ultrasound and CT for a large painful mass of the right breast that had been evolving for 30 years and gradually increasing in size. There was a typical "sausage slice" appearance with clear center macrocalcifications on the mammogram; an aspect of "breast in the breast" on ultrasound. The scanner had made it possible to specify the dimensions of the mass, which measured 21.4 cm in height; 18.6 cm wide and 9.5 cm thick. Histology after exeresis noted the adenolipofibromatous nature of the mass.

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Ductal carcinoma in situ arising in mammary hamartoma

Cited by 27 publications

References 8 publications

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Infarction of a Giant Breast Hamartoma in a Pregnant Patient Mimicking an Inflammatory Breast Cancer

Giant Breast Hamartoma: A Case Report in Togo

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