Ductal carcinoma in-situ arising within benign phyllodes tumours

Abstract

Ductal carcinoma in situ arising within a benign phyllodes tumour is a rare neoplasm of the breast. We present a case of a 19-year-old woman who had a right breast lump for six months with the above diagnosis together with a mini-review of the literature. Ultrasound revealed a 5-cm breast lump and core biopsy revealed ductal carcinoma in situ. She underwent wide local excision of the breast lump with clear margins. Final histology confirmed ductal carcinoma in situ within a fibroepithelial lesion consistent with a benign phyllodes tumour. To our knowledge, this is the youngest case of ductal carcinoma in situ arising in a phyllodes tumour to have been reported so far.

High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumour: A report of a case and literature review

“…Including this case study, 47 published cases were analysed (Table 1) (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). All of them were female patients aged between 19 and 80 years old (mean age = 47.6 years old and median age = 49 years old).…”

Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation

“…Invasive carcinomatous lesions associated with phyllodes tumors of the breast are exceedingly rare, with fewer than 20 cases described in the last 50 years [4] , [10] . The majority of histological types being ductal invasive carcinomas/NST, invasive lobular carcinomas or squamous cell carcinomas [4] , [10] , [11] .…”

“…Invasive carcinomatous lesions associated with phyllodes tumors of the breast are exceedingly rare, with fewer than 20 cases described in the last 50 years [4] , [10] . The majority of histological types being ductal invasive carcinomas/NST, invasive lobular carcinomas or squamous cell carcinomas [4] , [10] , [11] . These carcinomas are most often associated with benign phyllode tumors (60–80% of cases) but much more rarely with borderline or malignant ones [11] , [12] , [13] , [14] .…”

“…These carcinomas are most often associated with benign phyllode tumors (60–80% of cases) but much more rarely with borderline or malignant ones [11] , [12] , [13] , [14] . The molecular biological mechanisms associated with the development of these carcinomatous lesions in phyllode tumors remain poorly understood [4] , [5] , [10] , [13] . For the first time in this work, we were able to demonstrate the presence of mutations in the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene.…”

“…Carcinomatous lesions associated with phyllodes tumors are extremely rare and are found in less than 1% of all cases. The majority of them being carcinoma in situ but invasive lesions have also been described in exceptional cases [4] , [5] . To date, the molecular biological mechanisms associated with this carcinomatous transformation, as well as their potential therapeutic implications, remain unknown.…”