Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation correlation of pathologic parameters with outcome of treatment

Solin, Lawrence J.; Yeh, I‐Tien; Kurtz, John M.; Fourquet, A.; Recht, Abram; Kuske, Robert R.; McCormick, Beryl; Cross, Michael; Schultz, Delray; Amalric, R; LiVolsi, Virginia A.; Kowalyshyn, Michael J.; Torhorst, J.; Jacquemier, Jocelyne; Westermann, Cindy D.; Mazoujian, Gwen; Zafrani, B; Rosen, Paul Peter; Goodman, Robert L.; Fowble, Barbara

doi:10.1002/1097-0142(19930415)71:8<2532::aid-cncr2820710817>3.0.co;2-0

Cited by 199 publications

(77 citation statements)

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“…Most previous studies of recurrence following treatment of DCIS have found a higher incidence of both DCIS and invasive carcinoma following high-grade DCIS, at least in the short term (Lagios et al, 1989;Schwartz et al, 1992;Bellamy et al, 1993;Solin et al, 1993;Sneige et al, 1995;Silverstein et al, 1996;Fisher et al, 1999). In the EORTC study, although the risk of DCIS recurrence was found to be significantly related to the initial histology, the risk of invasive recurrence was not (Bijker et al, 2001a).…”

Section: Discussionmentioning

confidence: 95%

“…Owing to the potential for metastasis, the latter are of considerable significance as the chance of successful eradication of the disease may have been lost. In several studies the incidence of recurrence, at least in the short term, has been found to be higher following high-grade (poorly differentiated) DCIS than following low-grade (well differentiated) lesions (Lagios et al, 1989;Schwartz et al, 1992;Bellamy et al, 1993;Solin et al, 1993;Sneige et al, 1995;Silverstein et al, 1996;Fisher et al, 1999). Moreover, in some studies, the incidence of an invasive recurrence has been found to be higher after high-grade DCIS than after low-grade lesions (Lagios et al, 1989;Bellamy et al, 1993).…”

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confidence: 99%

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Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast

et al. 2004

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The grade of recurrent in situ and invasive carcinoma occurring after treatment of pure ductal carcinoma in situ (DCIS) has been compared with the grade of the original DCIS in 122 patients from four different centres (The Royal Marsden Hospitals, London and Sutton, 57 patients; Guy's Hospital, London, 19 patients; Nottingham City Hospital, 31 patients and The Royal Liverpool Hospital, 15 patients). The recurrent carcinoma was pure DCIS in 70 women (57%) and in 52 women (43%) invasive carcinoma was present, which was associated with an in situ element in 43. In all, 19 patients developed a second recurrence (pure DCIS in 11 and invasive with or without an in situ element in eight). The majority of invasive carcinomas followed high-grade DCIS. There was strong agreement between the grade of the original DCIS and that of the recurrent DCIS (k ¼ 0.679), which was the same in 95 of 113 patients (84%). The grade of the original DCIS showed only fair agreement with the grade of recurrent invasive carcinoma (k ¼ 0.241), although agreement was stronger with the pleomorphism score of the recurrent carcinoma (k ¼ 0.396). There was moderate agreement, in recurrent invasive lesions, between the grade of the DCIS and that of the associated invasive element (k ¼ 0.515). Other features that showed moderate or strong agreement between the original and recurrent DCIS were necrosis and periductal inflammation. The similarity between the histological findings of the original and subsequent DCIS is consistent with the concept that recurrent lesions represent regrowth of residual carcinoma. In addition, although agreement between the grade of the original DCIS and that of any subsequent invasive carcinoma was only fair, there is no suggestion that low-grade DCIS lesions progress to higher grade lesions or to the development of higher grade invasive carcinoma. This is in agreement with immunohistochemical and molecular data indicating that low-grade and high-grade mammary carcinomas are quite different lesions.

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Section: Discussionmentioning

confidence: 95%

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Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast

et al. 2004

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“…16 The significance of both grade and necrosis in predicting local recurrence of DCIS has been demonstrated in several studies. 5,14,20,[24][25][26][27] These factors were the basis for the Van Nuys classification for DCIS. In a study by Sanders et al 4 in 2005, a small group of patients diagnosed with low-grade DCIS treated with biopsy only were analyzed with long-term follow-up.…”

Section: Discussionmentioning

confidence: 99%

Prognostic markers and long-term outcomes in ductal carcinoma in situ of the breast treated with excision alone

Holmes

Lloyd

Chervoneva

et al. 2011

Cancer

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“…Although several prognostic factors have been elaborated for certain types of DCIS, the clinical outcome of DCIS in an individual patient is not exactly known (Holland et al, 1994;Silverstein et al, 1990Silverstein et al, , 1995aSolin et al, 1993). Molecular markers associated with speci®c forms of DCIS and their progression to invasive ductal carcinoma should provide improved, i.e.…”

Section: Introductionmentioning

confidence: 99%

A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland

et al. 2000

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Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation correlation of pathologic parameters with outcome of treatment

Cited by 199 publications

References 24 publications

Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast

Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast

Prognostic markers and long-term outcomes in ductal carcinoma in situ of the breast treated with excision alone

A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland

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