Ductal carcinoma in situ of the breast: correlation between mammographic and pathologic findings.

Evans, Andy; Pinder, Sarah; Wilson, Robin; Sibbering, Mark; Poller, David; Elston, C. W.; Ellis, Ian O.

doi:10.2214/ajr.162.6.8191988

Cited by 111 publications

(70 citation statements)

References 18 publications

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“…Similar to what we observed in the dog, the incidence of calcification in human DCIS ranges between 42% and 72% (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Up to 90% of DCIS lesions in human are detected on the basis of mammograpically visible microcalcifications (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). All canine DCISs were associated with comedo-type carcinoma and contained microcalcification and, interestingly, were mammographically detected.…”

Section: Discussionsupporting

confidence: 72%

Mammography and Ultrasound Imaging of Preinvasive and Invasive Canine Spontaneous Mammary Cancer and Their Similarities to Human Breast Cancer

Mohammed¹,

Meloni²,

Parpaglia³

et al. 2011

Cancer Prevention Research

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Understanding the evolution of proliferative breast disease such as atypical hyperplasia and carcinoma in situ is essential for clinical management of women diagnosed with these lesions. Therefore, an animal model that faithfully represents human breast disease in every aspect from spontaneity of dysplasia onset, histopathologic features, and genetics to clinical outcome is needed. Previously, we studied canine spontaneous atypical hyperplasia and ductal carcinoma in situ (low, intermediate, and high grade) and reported their similarities to human lesions in histopathologic and molecular features as well as prevalence. To further validate the resemblance of these lesions to humans, we examined their mammographic and sonographic characteristics in comparison with those of human's as well as the potential of the human Breast Imaging Reporting and Data System (BI-RADS) to predict canine disease. Nonlesional, benign, and malignant mammary glands of dogs presented to Sassari Veterinary Hospital were imaged using mammography and ultrasonography. The images where then analyzed and statistically correlated with histopathologic findings and to their similarities to humans. Our results showed that canine mammary preinvasive lesions, benign, and malignant tumors have mammographic abnormalities, including the presence, pattern, and distribution of macrocalcification and microcalcification, similar to their human counterparts. BI-RADS categorization is an accurate predictor of mammary malignancy in canine, with 90% sensitivity and 82.8% specificity. The similarities of mammographic images and the ability of BI-RADS to predict canine mammary malignances with high specificity and sensitivity further confirm and strengthen the value of dog as a model to study human breast premalignancies for the development of prognostic biomarkers.

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Section: Discussionsupporting

confidence: 72%

Mammography and Ultrasound Imaging of Preinvasive and Invasive Canine Spontaneous Mammary Cancer and Their Similarities to Human Breast Cancer

Mohammed¹,

Meloni²,

Parpaglia³

et al. 2011

Cancer Prevention Research

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“…Further examinations like a core needle biopsy or vacuumassisted biopsy are needed for clarification or exclusion of malignancy [6]. However in up to 40% (mostly in low grade DCIS) no calcifications can be seen [7].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the extent of microcalcifications to predict the size of a ductal carcinoma in situ: comparison between tomosynthesis and conventional mammography

Berger

Schwizer

Varga³

et al. 2016

Clinical Imaging

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OBJECTIVES The objective was to determine if digital tomosynthesis of the breast (DBT) assesses the extension of ductal carcinoma in situ (DCIS) with higher precision than mammography (MG). MATERIAL AND METHODS The local ethics committee approved this retrospective study including 26 patients with DCIS, which were rated by three radiologists. Statistics were performed using intraclass correlation (ICC) for interreader agreement and the Pearson correlation for correlation of MG and DBT. Standard of reference was the histologic extension. RESULTS The ICC was excellent. Correlation between MG and histology was 0.879 (P<.01) and for DBT and histology was 0.914 (P<.01). CONCLUSION DBT provides a slightly better estimation of the size of a DCIS than MG. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Abstract ObjectivesIf digital tomosynthesis of the breast (DBT) assesses the extension of Ductal carcinoma in situ (DCIS) with higher precision than mammography (MG). Material and MethodsRetrospective and local ethic committee approved study including 26 DCIS, which were rated by three radiologists. Statistics were performed using intraclass correlation (ICC) for interreader agreement and the Pearson's Correlation for correlation of MG and DBT. Standard of reference was the histologic extension. ResultsThe ICC was excellent. Correlation between MG and histology was 0.879(p<0.01) and for DBT and histology 0.914(p<0.01). ConclusionDBT provides a slightly better estimation of the size of a DCIS than MG.

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“…Studies on the radiological appearance of DCIS subtypes have shown that mammography has a high sensitivity in the detection of high-grade DCIS owing to the high frequency of visible calcification of intraductal necrotic debris; however, this technique is much less sensitive in demonstrating the presence of low-grade DCIS (Holland et al, 1990, Evans et al, 1994a. These findings suggest a correlation between mammographically visible linear/branching calcification and high-grade invasive carcinoma.…”

Section: Aj Evans Et Al Discussionmentioning

confidence: 99%

“…Highgrade DCIS, which is usually mammographically visible (Holland et al, 1990;Evans et al, 1994a), as calcification is frequently associated with high-grade invasive tumours. A previous study has shown calcification to be a common feature of grade 3 screen-detected tumours (De Nunzio et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

The detection of ductal carcinoma in situ at mammographic screening enables the diagnosis of small, grade 3 invasive tumours

Evans

Pinder²,

Snead³

et al. 1997

Br J Cancer

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Summary This study was carried out to assess the frequency of ductal carcinoma in situ (DCIS) occurring within and surrounding grade 3 invasive tumours and the effect of its detection on size and nodal stage of invasive carcinomas at mammographic detection. Grade 3 tumours with either no associated DCIS or DCIS only within the invasive component were significantly larger in size than tumours with surrounding DCIS (P<0.02) and were less likely to be under or equal to 10 mm in size (0% or 13% vs 30% respectively, P<0.02). Tumours with mammographic calcification were more likely to be less than or equal to 10 mm in size than non-calcific tumours (32% vs 11% respectively, P<0.05). This was because of the high frequency of tumours less than or equal to 10 mm in size in the linear/branching calcification group. Tumours showing calcification without a mass also appear to be a group with good prognostic features, with a mean size of 13 mm, 33% being 10 mm or less in size and only 17% being node positive. We have found that the presence of surrounding DCIS enables earlier detection of grade 3 invasive carcinomas because of the presence of mammographically visible calcification. Detection of calcification suggestive of DCIS should remain an important part of mammographic screening.

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Ductal carcinoma in situ of the breast: correlation between mammographic and pathologic findings.

Cited by 111 publications

References 18 publications

Mammography and Ultrasound Imaging of Preinvasive and Invasive Canine Spontaneous Mammary Cancer and Their Similarities to Human Breast Cancer

Mammography and Ultrasound Imaging of Preinvasive and Invasive Canine Spontaneous Mammary Cancer and Their Similarities to Human Breast Cancer

Assessment of the extent of microcalcifications to predict the size of a ductal carcinoma in situ: comparison between tomosynthesis and conventional mammography

The detection of ductal carcinoma in situ at mammographic screening enables the diagnosis of small, grade 3 invasive tumours

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