Ductal Carcinoma In Situ That Involves Sclerosing Adenosis: High Frequency of Bilateral Breast Cancer Occurrence

Yoshida, Atsushi; Hayashi, Naoki; Akiyama, Futoshi; Yamauchi, Hideko; Uruno, Takashi; Kikuchi, Mari; Yagata, Hiroshi; Tsugawa, Koichiro; Suzuki, Koyu; Nakamura, Seigo; Tsunoda, Hiroko

doi:10.1016/j.clbc.2012.08.002

Cited by 15 publications

(15 citation statements)

References 15 publications

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“…Sclerosing adenosis is a proliferative lesion derived from the terminal ductal lobular unit having the features of both adenosis and stromal sclerosis . We have previously reported that sclerosing adenosis was a high risk factor for bilateral breast cancer . Our report indicated that sclerosing adenosis may be less likely than non‐sclerosing adenosis to upstage to invasive carcinoma.…”

Section: Discussionmentioning

confidence: 62%

A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast

Kondo

Hayashi

Ohde

et al. 2015

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 62%

A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast

Kondo

Hayashi

Ohde

et al. 2015

Journal of Surgical Oncology

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“…Whereas partial mastectomy for patients with SA-DCIS was preferred by Yoshida et al , who argued that total mastectomy was unnecessary 5. Simple mastectomy with SLNB was the most prevalent strategy adopted in our series.…”

Section: Discussionmentioning

confidence: 90%

Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Tang

et al. 2018

J Clin Pathol

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CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality.

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“…14,15 The frequency of bilateral breast cancer in all breast cancer patients was 1.6% to 7%, 16,17 whereas the frequency of bilateral breast cancer in Bc-SA was as high as 27%. 17 In a retrospective study analyzing 117 synchronous bilateral breast cancer and 7400 unilateral breast cancer patients, the author indicated that the presence of SA was a risk factor for developing synchronous bilateral breast cancer (hazard ratio: 11.8; 95% confidence interval: 5.3–26.3; P < 0.001).…”

Section: Discussionmentioning

confidence: 92%

“…2 In addition, several studies reported that architectural distortion was more often associated with Bc-SA. Yoshida et al 15 reported that architectural distortion was more frequent in patients with SA-DCIS compared with those with non-SA DCIS (15, 54% vs. 5, 2%, P < 0.01) on mammography; Ogura et al 5 reported 13 (46%) cases with architectural distortion in a study of 28 Bc-SA cases. One possible explanation was that architectural distortion became apparent as cancer developed or grew into the sclerotic stroma of SA.…”

Section: Discussionmentioning

confidence: 97%

Breast Sclerosing Adenosis and Accompanying Malignancies

et al. 2015

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Sclerosing adenosis (SA) is a less common histopathological lesion of the breast that can coexist with proliferative lesions as well as malignancies. We aimed to analyze the clinicopathological characteristics of SA and to investigate the radiological features of SA.Patients who underwent breast surgery at our institute from 2007 to 2013 were retrospectively reviewed. A total of 815 breasts (722 patients) were included in the final analysis. Synchronous bilateral SA was defined as the detection of another SA arising in the contralateral breast within 1 month after surgery for the initial breast lesion. Baseline characteristics, imaging records (ultrasonography, mammography, and magnetic resonance imaging [MRI]), and pathology were included in the analysis.The median age at diagnosis was 47 years old. The majority of patients had unilateral non-Bc-SA (457/722). Among 102 patients with bilateral SA, 78.4% were diagnosed synchronously. In total, 26 patients suffered from synchronous bilateral breast cancer. Upon final pathological investigation, 226 cases were SA involving breast cancer (Bc-SA), most (56.2%) of which were ductal carcinoma in situ (DCIS). In addition, lobular carcinoma in situ (LCIS) and diseases that involved LCIS also comprised up to 11.1% of cases. The majority of SA cases (405; 49.7%) had no obvious symptoms except for imaging changes in mammography or ultrasound. Compared with non-Bc-SA cases, Bc-SA cases were more likely to exhibit features of mass (32.8% vs. 28.6%) and architectural distortion (20.4% vs. 13.0%) on mammography. Ultrasonography, mammography, and MRI revealed unsatisfactory sensitivity and specificity to differentiate Bc-SA from non-Bc-SA. MRI exhibited the highest sensitivity and lowest specificity, whereas the specificity of mammography was as low as 50.0%.A tendency for synchronous bilaterality in both Bc-SA and non-Bc-SA was noted. DCIS was the most commonly observed malignancy involved in Bc-SA. Although most patients with SA were asymptomatic, the ability of imaging studies to accurately differentiate non-Bc-SA from Bc-SA remained unsatisfactory.

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Ductal Carcinoma In Situ That Involves Sclerosing Adenosis: High Frequency of Bilateral Breast Cancer Occurrence

Cited by 15 publications

References 15 publications

A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast

A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast

Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions

Breast Sclerosing Adenosis and Accompanying Malignancies

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