Ductal Carcinoma of the Prostate: An Uncommon Entity With Atypical Behaviour

WITHDRAWN: First Case of Ductal Adenocarcinoma of the Prostate with MAP3K1 Homozygous Deletion: A Case Report and Literature Review

“…[13] Radiotherapy is a suitable de nitive treatment option in the management of DAP; however, the optimal systemic therapy for metastatic ductal adenocarcinoma remains to be established. [14][15][16] Treatment for MAP3K1 loss depends on whether androgen receptor testing is positive or negative. When it is positive, MEK inhibitor therapy may be effective.…”

Ductal adenocarcinoma of the prostate: A systematic review and meta‐analysis of incidence, presentation, prognosis, and management

“…One study, Igdem 2010, reported RT to have more favorable biochemical relapse rates and cancer‐specific survival than RP 36 . Conversely, the same study reported RP to have more favorable overall survival than RT, 36 although a tendency for selecting RT in unfit men should be considered as a possible confounder here 37,38 . As such, although there is no clear consensus regarding the optimal treatment modality for DAC, it does seem that radiotherapy may be superior, perhaps because of the reduced likelihood of seeding of ductal cancer cells into the peritoneal cavity as might occur with radical prostatectomy.…”

Prostatic ductal adenocarcinoma variant predicts worse pathological and oncological outcomes: Insight from over 1000 consecutive patients from a large prospective uro‐oncology registry

“…In view of conflicting reports on the significance of the PDA histological variant in patients with prostate cancer, and to probe beyond pathological outcomes as most previous studies on this topic had focused on, this study aimed to evaluate the prognostic implications of PDA in localized prostate cancer patients. PDA is a rare subtype of prostate cancer (PCa), characterized by tall columnar cells that can be in simple or pseudo‐stratified layers, arranged in variable architectural patterns such as cribriform, papillary, solid, and PIN‐like pattern 1,12 . These different architectural features can be seen in combination or individually, forming several subtypes with variable clinical courses 1 .…”

“…Older studies supported aggressive biology with PDA, 2,4,5,8–10 associated with multiple adverse pathological outcomes 7,8,11 . In fact, it is typically assigned a Gleason score of 8 or 9 (if comedonecrosis is present), corresponding to the grade group (GG) 4 or 5 12 . However, seemingly going against this paradigm are the results of a more recent paper by Iakymenko et al 13 .…”