Ductal Lavage for Detection of Cellular Atypia in Women at High Risk for Breast Cancer

Dooley, William C.; Ljung, Britt Marie; Veronesi, Umberto; Cazzaniga, Massimiliano; Elledge, Richard M.; O’Shaughnessy, Joyce; Kuerer, Henry Mark; Hung, David T.; Khan, Seema A.; Phillips, Rogsbert F.; Ganz, Patricia A.; Euhus, David M.; Esserman, Laura J.; Haffty, Bruce G.; King, Bonnie L.; Kelley, Mark C.; Anderson, Maxine M.; Schmit, Paul J.; Clark, Ramona R.; Kass, Frederic C.; Anderson, Benjamin O.; Troyan, Susan L.; Arias, Raquel De Paz; Quiring, John; Love, Susan M.; Page, David L.; King, Eileen B.

doi:10.1093/jnci/93.21.1624

Cited by 256 publications

(265 citation statements)

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“…1,2 In the few studies that have examined the breast cancer risk associated with cytologic atypia, a finding of cytologic atypia was associated with a breast cancer risk similar to that reported in women with a finding of atypical hyperplasia on examination of histologic sections. 2,3 Although the cytologic criteria used to categorize intraductal epithelial changes are well defined, they have not been uniformly applied, and they have not been proven to be reproducible.…”

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confidence: 72%

“…4,5 In studies that have compared cytologic findings of atypia with histologic findings from corresponding tissue, the correlation was poor and the rate of false-positive results high. 1,5 Consequently, ancillary studies to better assess cellular changes are being sought. 6 Breast cancer progression is characterized by the accumulation of numeric changes on many chromosomes, particularly early or frequent increases in the copy numbers of chromosomes 1,8,11, and 17.…”

mentioning

confidence: 99%

“…1,5 Consequently, ancillary studies to better assess cellular changes are being sought. 6 Breast cancer progression is characterized by the accumulation of numeric changes on many chromosomes, particularly early or frequent increases in the copy numbers of chromosomes 1,8,11, and 17. [7][8][9][10][11][12][13][14][15][16] Fluorescence in situ hybridization (FISH) evaluation of chromosomal aberrations in ductal lavage specimens may be more sensitive and specific than conventional cytologic evaluation for categorization of breast lesions.…”

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confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16] Fluorescence in situ hybridization (FISH) evaluation of chromosomal aberrations in ductal lavage specimens may be more sensitive and specific than conventional cytologic evaluation for categorization of breast lesions. [17][18][19] To determine the utility of FISH in categorizing breast epithelial changes, we used this technique to evaluate numeric changes in chromosomes 1,8,11, and 17 in breast FNA specimens from 27 women at high risk for breast cancer. For comparison, we used cytologic smears from seven invasive ductal breast carcinomas and nine specimens of nonproliferative epithelium (NPE) from women at low risk for breast cancer.…”

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confidence: 99%

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Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

et al. 2006

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Cytologic evaluation of ductal lavage or random periareolar fine-needle aspiration (FNA) specimens has been proposed to improve risk stratification of women at high risk for breast cancer. However, cytologic assessment of morphologic changes is subjective. To assess the utility of fluorescence in situ hybridization (FISH) in the categorization of breast lesions, we prospectively evaluated 32 random periareolar FNA specimens from 27 women at high risk for breast cancer. Cytologic specimens were prepared using the thin preparation technique, and diagnoses were made on the basis of previously published criteria. Specimens were also evaluated by FISH for chromosomes 1, 8, 11, and 17. Monosomy was defined as the loss of one signal or both signals in 420% of cells, and polysomy was defined as the presence of Z3 signals in 46% of cells. Cytologic smears from seven invasive ductal carcinomas and nine benign breast specimens from women at low risk for breast cancer were included for comparison. In the high-risk group, cytologic findings were nonproliferative epithelium (NPE) in 16 cases and hyperplasia in 16 cases. Chromosomal aberrations were detected in 11 (69%) of 16 NPE cases, 14 (89%) of 16 hyperplasia cases, seven (100%) of seven carcinoma cases, and none of the low-risk cases. Highrisk cases had significantly more monosomy of chromosomes 1, 11, and 17 and polysomy of chromosome 8 compared to low-risk cases and significantly less polysomy of chromosomes 1, 8, 11, and 17 compared to patients with cancer. There were no significant differences in monosomy or polysomy of individual chromosomes or a combination of chromosomes between the NPE and hyperplasia groups. This study shows that aberrations of chromosome number are common in high-risk women irrespective of cytologic findings. Studies evaluating the association between specific patterns of chromosomal polysomy and progression to malignancy may be warranted.

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confidence: 72%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

et al. 2006

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“…43,44 Mild atypia may suggest an unrecognized malignant lesion or may represent a highrisk lesion with the potential to become malignant. We identified 7 women with atypical cytology, 42.9% of whom were BRCA carriers, out of 30 women who underwent successful DL in our high-risk cohort.…”

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confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Thermal analysis of high‐density polyethylene and low‐density polyethylene with enhanced biodegradability

Contat‐Rodrigo

Ribes‐Greus

Imrie

2002

J of Applied Polymer Sci

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ABSTRACT:The thermal properties of high-density polyethylene (HDPE) and low-density polyethylene (LDPE) filled with different biodegradable additives (Mater-Bi AF05H, Cornplast, and Bioefect 72000) were investigated with thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The DSC traces of the additives indicated that they did not undergo any significant phase change or transition in the temperature region typically encountered by a commercial composting system. The TGA results showed that the presence of the additive led to a thermally less stable matrix and higher residue percentages. The products obtained during the thermodegradation of these degradable polyolefins were similar to those from pure polyethylenes. The LDPE blends were thermally less stable than the HDPE blends.

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Ductal Lavage for Detection of Cellular Atypia in Women at High Risk for Breast Cancer

Abstract: Large numbers of ductal cells can be collected by ductal lavage to detect atypical cellular changes within the breast. Ductal lavage is a safe and well-tolerated procedure and is a more sensitive method of detecting cellular atypia than nipple aspiration.

Cited by 256 publications

References 23 publications

Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Thermal analysis of high‐density polyethylene and low‐density polyethylene with enhanced biodegradability

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