Ductus Arteriosus

Desligneres, S; Jc, Larroche

doi:10.1159/000240286

Cited by 32 publications

(2 citation statements)

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“…Within a few days after birth, the mammalian ductus arteriosus and ductus venosus become functionally closed, and later anatomically closed, and thus represent a natural model, free of experimental perturbations, for studying the effects of occlusion and consequent hypoxia on vascular endothelial and smooth muscle cell morphology. Light microscope studies indicate that several pathological changes which commonly occur in atherosclerosis, such as intimal thickening and cell necrosis, also commonly occur in closing ductus vasculature (Desligneres and Larroche, 1970;Gittenberger-deGroot, 1977). Detailed electron microscope studies of closing ductus vasculature are quite limited, however; only studies of rat (Mato and Aiwaka, 1968;Mato et al, 1970) and human (Toda et al, 1980b) ductus arteriosus have been reported, and these studies dealt mainly with fetal and neonatal cases.…”

mentioning

confidence: 99%

Degenerative changes in endothelial and smooth muscle cells from aging swine ductus arteriosus and venosus

1981

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Degenerative changes in endothelial and smooth muscle cells from fetal, 2-month-, and 6-month-old swine ductus vasculature were observed. In fetal ductus, a discontinuous internal elastic lamina and increased extracellular mucopolysaccharide deposition were initially noted. At 2 months of age, there was widespread fibromuscular intimal thickening, the appearance of modified smooth muscle cells, increased medial fibrosis, and the occurrence of cell debris and nuclear pyknosis. Early modification of smooth muscle cells was marked by increased occurrence of lysosomes, widely dilated rough endoplasmic reticulum, and Golgi bodies. Abundant aggregates of Weibel-Palade bodies occurred in early endothelial cell degeneration. At 6 months of age, after complete anatomical closure, there was abundant lipid vacuole production by degenerated medial smooth muscle cells. This study demonstrates that at various stages of occlusion, endothelial and smooth muscle cells from ductus vasculature exhibit morphological changes which are qualitatively similar to atherosclerosis.

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confidence: 99%

Degenerative changes in endothelial and smooth muscle cells from aging swine ductus arteriosus and venosus

1981

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“…Proliferation of inti ma and media producing mounds, mucoid-filled spaces, and fragmentation of the internal elastic membrane, leads to anatomical obliteration during the first weeks to months of life [15]. But there is evidence that intimal and subintimai proliferation begins before birth forming 'cu shions' that protrude into the lumen [17,18].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Idopathic Stenosis of the Ductus arteriosus Associated with Fetal Atrial Flutter

Mielke

Steil²,

Gonser³

1997

Fetal Diagn Ther

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Antenatal stenosis or closure of the ductus arteriosus unrelated to either congenital heart defects or prostaglandin inhibitors is considered to be uncommon, but may result in congestive heart failure, hydrops fetalis, and perinatal death. We report a case of idiopathic ductal stenosis detected prenatally by two-dimensional and Doppler echocardiography in a fetus presenting atrial flutter and right atrial dilatation at 31 weeks of gestation. Prenatal treatment with digoxin and verapamil resulted in conversion to sinus rhythm. The fetus was closely monitored. Congestive heart failure did not develop, and the fetus was delivered spontaneously in good condition at 39 weeks of gestation. In case of ductal stenosis, the potential risk of congestive heart failure must be considered, and maternal administration of drugs with constrictive effects on the ductus arteriosus, as indomethacin or betamethasone, should be avoided.

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Early Functional Closure of the Ductus Arteriosus Associated With Decreased Severity of Respiratory Distress Syndrome in Preterm Infants

Thibeault¹,

Emmanouilides²,

Dodge³

et al. 1977

Arch Pediatr Adolesc Med

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\s=b\It has been shown that a patent ductus arteriosus may complicate the course of the respiratory distress syndrome (RDS) in preterm infants. In this study, an attempt is made to answer the question: Is there any relationship between RDS and patency of the ductus arteriosus in preterm infants, that is, do preterm infants without the RDS have early functional closure of the ductus arteriosus? Clinical observations were made on 144 preterm infants 25 to 34 weeks' gestation. Infants were included in the study if the status of the ductus arteriosus (open or closed) could be established either by clinical examination or retrograde aortography. The ductus arteriosus was closed in 59 infants within 48 hours of birth and open in 85. None of the infants with a closed ductus had severe RDS and only three had mild RDS. In contrast, 50% (43 of 85) of infants with open ductus had severe RDS. These findings suggest that early functional closure of the ductus can occur even invery immature infants, and this early closure appears to be associated with a decreased incidence of RDS.

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Ductus Arteriosus

Cited by 32 publications

References 4 publications

Degenerative changes in endothelial and smooth muscle cells from aging swine ductus arteriosus and venosus

Degenerative changes in endothelial and smooth muscle cells from aging swine ductus arteriosus and venosus

Prenatal Diagnosis of Idopathic Stenosis of the Ductus arteriosus Associated with Fetal Atrial Flutter

Early Functional Closure of the Ductus Arteriosus Associated With Decreased Severity of Respiratory Distress Syndrome in Preterm Infants

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