Leukemia is a chronic disease that affects children's physiology, psychology, also their growth, and development. It also impacts children life quality. Acute lymphoblastic leukemia (ALL) disease and its chemotherapy give some effects on children. The effects can be reduced by the nurse through an atraumatic care intervention using implementing complementary therapies. The objective of this therapy is to improve and maintain children's life quality. The goal of this research is to describe the effectiveness of complementary therapies in children with ALL (Acute Lymphoblastic Leukemia). This study uses the literature review method by selecting some journal articles using the PICO technique. The exclusion-inclusion criteria in selecting the journal article are: published in the latest 5 years (2016-2021), used Indonesian and English language, available in the full-text format, and has a specific theme in complementary therapy for children with ALL. Based on the analysis of the articles, it is concluded that most of the interventions in therapy can reduce some symptoms because of ALL diseases and the side effect of chemotherapy. From this study, it is suggested that some successfully proven interventions can be applied and implemented independently by the family with ALL diseases children. It is also recommended to be used as a nursing care intervention in development centers/services.