Duloxetine and placebo alter different gray matter regions in chronic low back pain patients

Chatterjee, Neil; Noor, N.; Crowell, Andrea; Mackey, Sean

doi:10.1016/j.jpain.2010.01.169

Cited by 1 publication

(1 citation statement)

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“…Previous research suggests these medications are associated with changes in brain structure, including reduced gray matter volume associated with pregabalin administration among FM patients, 34 and altered gray matter associated with duloxetine administration in osteoarthritis 35 and chronic low pain back pain. 36 Accordingly, medication use may also be a critical confound in VBM and should examined among larger samples in the future.…”

Section: Limitationsmentioning

confidence: 99%

Attempt to replicate voxel-based morphometry analysis in fibromyalgia: Detection of below threshold differences framed by contributions of variable clinical presentation to low reproducibility

Baker

Nanda

Park

et al. 2022

Preprint

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Background: Fibromyalgia is a prevalent chronic pain condition characterized by widespread pain and sensory hypersensitivity. While much remains unknown about the neurobiological underpinnings of fibromyalgia, central nervous system alterations appear to be heavily implicated in its pathophysiology. Previous research examining brain structural abnormalities associated with fibromyalgia has yielded inconsistent findings. Thus, we followed previous methods to examine brain gray matter differences in fibromyalgia. We hypothesized that, relative to healthy controls, participants with fibromyalgia would exhibit lower gray matter volume in regions consistently implicated in fibromyalgia: the anterior cingulate cortex and medial prefrontal cortex. Methods: This study used magnetic resonance imaging to evaluate regional and whole brain differences in gray matter among females with and without fibromyalgia. Group differences were analyzed with two-sample t-tests, controlling for total intracranial volume. Results: No significant differences in regional or whole brain gray matter volumes were detected between fibromyalgia and healthy controls. Conclusions: Results add to an existing body of disparate findings regarding brain gray matter volume differences in fibromyalgia, and suggest structural differences previously detected in fibromyalgia should be examined for reproducibility. Absent significant differences may also suggest that functional, but not structural, brain adaptations are primarily associated with fibromyalgia.

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Section: Limitationsmentioning

confidence: 99%