Duloxetine for Postoperative Pain Control Following Knee or Hip Replacement: A Systematic Review and Meta-Analysis

The efficacy of peri-operative duloxetine on reducing post-operative pain and opioid doses – literature review

“…In this group, a significant reduction in pain was also observed, lasting until the sixth week after surgery for pain assessed at rest and up to three months for pain assessed at movement. The main limitations of this work, according to the authors themselves, were the variable drug administration and placebo regimens used in the included studies [35].…”