Dumb-Bell Ganglioneuroma of the Cervical Spine

Strang, R. R.; Nordenstam, H

doi:10.1111/j.1600-0404.1962.tb01078.x

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Enzinger and Weiss [1] described 2 of 88 ganglioneuromas that originated from the cervical spine, albeit the detailed fi gures were unknown. Pang et al [12] reviewed the anatomical location of 23 reported cases of spinal ganglioneuromas, and categorized the ganglioneuromas of the spine and spinal cord reported in the literature into intramedullary [7,20] , extramedullary / intradural [10,21] , extradural / dumb-bell tumors and the latter ones were found to occur in about 70 % of all spinal cases. Kyoshima et al [3] reported an unusual case of multiple ganglioneuromas at bilateral C2 and C3 levels, and reviewed reported cases presenting with dumb-bell pattern.…”

Section: Discussionmentioning

confidence: 99%

Microsurgical Excision of Ganglioneuroma Arising from the C8 Nerve Root within the Neuroforamen

Uchida

Kobayashi²,

Kubota³

et al. 2007

Minim Invasive Neurosurg

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Ganglioneuromas are benign, slow-growing tumors originating from sympathetic nerves or peripheral nerves, often associated with multiple tumor syndromes. They occasionally occur as spinal lesions and grow within the spinal canal or as paraspinal lesions. In this report, we describe a rare solitary ganglioneuroma arising from the cervical nerve root (C8) within the intervertebral foramen in adults. The tumor could be detected as a mass limited to the neuroforamen at an early stage by MR images. Unilateral microsurgical foraminotomy and EN BLOC resection of the tumor resulted in disappearance of the symptoms. Microsurgical resection of the relevant nerve root through limited medial foraminotomy at an intricate anatomical region of the cervico-thoracic junction was appropriate in the current case for complete resection of the tumor as well as to prevent postoperative structural weakness that could result in late segmental instability.

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Section: Discussionmentioning

confidence: 99%

Microsurgical Excision of Ganglioneuroma Arising from the C8 Nerve Root within the Neuroforamen

Uchida

Kobayashi²,

Kubota³

et al. 2007

Minim Invasive Neurosurg

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“…17 Among them, dorsal root ganglion-derived GN is extremely rare 18 and only 10 cases of intradural GN derived from cervical dorsal root ganglia have been reported. 3,[19][20][21][22][23][24][25] We summarize the previously reported cases and the current case and found that a dumbbell-shaped tumor is most frequently seen and half exhibit multiple tumors (Table 1). Although multiple-tumor cases suggest an association with neurofibromatosis type 1 (NF-1), it remains unknown genetic relation between NF-1 and GN.3 Sporadic cases tend to exhibit C2 dorsal ganglion-derived GN similar to the current case, implying an association with GN development.…”

Section: Observationsmentioning

confidence: 65%

Cervical ganglioneuroma arising from the dorsal root ganglion: illustrative case

Torimaki¹,

Sasaki²,

Ohara³

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Ganglioneuroma is a benign and well-differentiated tumor derived from neural crest cells, which occurs infrequently, with most patients being female and adolescents. While predilection sites are the posterior mediastinum and retroperitoneal cavity, ganglioneuroma originating from the dorsal root ganglion is very rare. Here the authors report a case with C2 dorsal root ganglion-derived ganglioneuroma with some literature review. OBSERVATIONS A 45-year-old male patient complained of persistent right-side throbbing occipital headache for more than a year. Magnetic resonance imaging (MRI) of the cervical spine revealed a dumbbell-shaped intradural extramedullary tumor from the C2 posterior surface of the odontoid to right C1–2 intervertebral foramen with high T2- and low T1-weighted signal intensities. The tumor displayed homogeneous contrast enhancement by MRI. The authors suspected schwannoma and performed a tumorectomy for both diagnosis and treatment purposes. Intraoperative findings showed that the tumor originated from the dorsal root ganglion, and pathological examination revealed ganglioneuroma. Immediately after the tumorectomy, the throbbing occipital headache disappeared and the patient was discharged from the hospital without major complications. LESSONS Although ganglioneuroma derived from the dorsal root ganglion is very rare, a differential diagnosis of the ganglioneuroma should be made, when schwannoma is suspected.

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“…La primera descripción de un ganglioneuroma se realizó en 1870 4 , y aunque desde entonces se han descrito varios casos [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] , sigue tratándose de un tumor poco frecuente. Como su nombre indica, está compuesto por células ganglionares maduras 19 y asienta en aquellos tejidos derivados embriológicamente de la cresta neural, principalmente en el sistema nervioso autónomo.…”

Section: Discussionunclassified

Ganglioneuromas cervicales y su relación con la neurofibromatosis tipo 1

Jiménez-Zapata¹,

Fernández-García²,

Sánchez-Fernández³

et al. 2022

CIRU

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Los ganglioneuromas son tumores de lento crecimiento que se originan en tejidos derivados de la cresta neural, principalmente en el sistema nervioso autónomo. Se localizan sobre todo en el mediastino posterior, siendo la afectación intraespinal muy poco frecuente. Presentamos el caso de una mujer intervenida de ganglioneuromas localizados en la columna cervical y agrupamos los casos descritos previamente en la literatura inglesa revisando las características principales de estas neoplasias e incluyéndolas en el espectro de manifestaciones de la neurofibromatosis tipo 1.

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Dumb-Bell Ganglioneuroma of the Cervical Spine

Cited by 11 publications

References 9 publications

Microsurgical Excision of Ganglioneuroma Arising from the C8 Nerve Root within the Neuroforamen

Microsurgical Excision of Ganglioneuroma Arising from the C8 Nerve Root within the Neuroforamen

Cervical ganglioneuroma arising from the dorsal root ganglion: illustrative case

Ganglioneuromas cervicales y su relación con la neurofibromatosis tipo 1

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