Dünnschicht‐Chromatographie von Aminosäuren auf Kieselgel G. 2. Mitteilung. Eine Schnellmethode zur Trennung und zum qualitativen Nachweis von 22 Aminosäuren

Fahmy, A. R.; Niederwieser, A.; Pataki, György; Brenner, M.

doi:10.1002/hlca.19610440727

Cited by 142 publications

(17 citation statements)

References 9 publications

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“…In Golgi silver stains (11) of 22 tadpole retinas we found only three of the four ganglion cell types in the adult frog-the "E" type, the "H" type, and the "broad" type ( Fig. 2); the constricted ganglion cell tree of the frog was absent in the tadpole.…”

mentioning

confidence: 85%

Synthesis of Amino Acids by the Heating of Formaldehyde and Ammonia

Fox

Windsor

1970

Science

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The heating of formaldehyde and ammonia yields a product that, on hydrolysis, is converted into seven amino acids: aspartic acid, glutamic acid, serine, proline, valine, glycine, and alanine. Glycine is the predominant amino acid. Inasmuch as formaldehyde and ammonia have been identified as compounds in galactic clouds, these experimental results are interpreted in a cosmochemical and geochemical context.

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confidence: 85%

Synthesis of Amino Acids by the Heating of Formaldehyde and Ammonia

Fox

Windsor

1970

Science

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“…Amine derivatives were detected by ninhydrin spray [30], followed by heating the sheets. Column chromatography was performed on silica gel columns (size A, 28 2; B, 30 2.5; and c, 43 4 cm; silica gel 0.040-0.063 mm.…”

Section: Experimental Partmentioning

confidence: 99%

Anti-Proliferative Effects of Novel Glyco-Lipid-Arsenicals (III) on MCF-7 Human Breast Cancer Cells

Wimmer¹,

Robinson²,

Gopisetty-Venkata³

et al. 2006

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Arsenic trioxide appears to be effective in the treatment of pro-myelocytic leukaemia. The substituted phenylarsen(III)oxides are highly polar, they have a high tendency to undergo oxidation to As (V) and to form oligomers, to prevent this we protected the As-(OH)(2) group as cyclic dithiaarsanes. To increase the compound's biological stability and passive diffusion we conjugated the compound of interest with lipoamino acids (Laas). Alternatively, we further conjugated the dithiaarsane derivative with a carbohydrate to utilize active transport systems and to target compound. We investigated two novel glyco-lipid arsenicals (III) (compounds 9 and 11) for their ability to initiate MCF-7 breast cancer cell death and characterized the mechanism by which death was initiated. A significant decrease in MCF-7 cell proliferation was observed using 1 microM and 10 microM compound (11) and 10 microM of compound (9). Treatment with compound (11) triggered apoptosis of MFC-7 cells while compound (9) induced inhibition of cellular proliferation was not via rapid induction of apoptosis and more likely reflected necrosis and/or alterations in the cell cycle. Differences in the anti-proliferative potency of the two compounds indicate that structural modifications influence effectiveness.

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“…Ein weiterer Vorteil der vor kurzem entwickelten Schutzgruppe [13] ist die starke lösungsvermittelnde Eigenschaft dieses Restes für polare Peptidzwischenstufen. Sichtbargemacht wurden die Chromatogramme in der Iodkammer mit Xinhydrin [14], mit Tolidin [15] und mit Sakaguchi-Reagenz [16]. …”

Section: Zusammenfassungunclassified

Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1- (1 -Adamantyl) -1 -methylethoxycarbonyl- Schutzgruppe+ / Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 - Adamantyl)-1 -methylethoxycarbonyl Group

Heinzel

Kronbach

Voelter

1982

Zeitschrift Für Naturforschung B

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A synthesis of high yields of TP 5 is described. The a-amino functions were blocked by the acid-labile 1-(1 -adamantyl)-1-methylethoxycarbonyl-(Adpoc)group. The Adpoc group is cleaved under mild acidolytic conditions with 3% TFA in CH2CI2 while the tert-butyl residues remained intact. This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides

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Dünnschicht‐Chromatographie von Aminosäuren auf Kieselgel G. 2. Mitteilung. Eine Schnellmethode zur Trennung und zum qualitativen Nachweis von 22 Aminosäuren

Abstract: A thin layer chromatographic methods for rapid separation and detection of 22 commonly occurring amino‐acids is described. Special reference is made to the analysis of protein hydrolysates and to the sensitivity of the ninhydrin reaction.

Cited by 142 publications

References 9 publications

Synthesis of Amino Acids by the Heating of Formaldehyde and Ammonia

Synthesis of Amino Acids by the Heating of Formaldehyde and Ammonia

Anti-Proliferative Effects of Novel Glyco-Lipid-Arsenicals (III) on MCF-7 Human Breast Cancer Cells

Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1- (1 -Adamantyl) -1 -methylethoxycarbonyl- Schutzgruppe+ / Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 - Adamantyl)-1 -methylethoxycarbonyl Group

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