Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease

Keely, Simon; Talley, Nick

doi:10.1111/nmo.13854

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…The colonic microbial communities have a well‐established role in metabolizing BAs to facilitate reabsorption [19]. Two studies (Boutte et al.…”

Section: Resultsmentioning

confidence: 99%

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Influence of the bile acid/microbiota axis in ileal surgery: a systematic review

Senanayake,

Makanyengo,

Hoedt

et al. 2024

Colorectal Disease

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AimThe gastrointestinal bile acid (BA)/microbiota axis has emerged as a potential mediator of health and disease, particularly in relation to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer. Whilst it presents an exciting new avenue for therapies, it has not yet been characterized in surgical resection of the ileum, where BA reabsorption occurs. The identification of BA/microbiota signatures may provide future therapies with perioperative personalized medicine. In this work we conduct a systematic review with the aim of investigating the microbiome and BA changes that are associated with resection of the ileum.MethodThe databases included were MEDLINE, EMBASE, Web of Science and Cochrane libraries. The outcomes of interest were faecal microbiome and BA signatures after ileal resection.ResultsOf the initial 3106 articles, three studies met the inclusion/exclusion criteria for data extraction. A total of 257 patients (46% surgery, 54% nonsurgery controls) were included in the three studies. Two studies included patients with short bowel syndrome and the other included patients with IBD. Large‐scale microbiota changes were reported. In general, alpha diversity had decreased amongst patients with ileal surgery. Phylum‐level changes included decreased Bacteroidetes and increased Proteobacteria and Fusobacteria in patients with an intestinal resection. Surgery was associated with increased total faecal BAs, cholic acid and chenodeoxycholic acid. There were decreases in deoxycholic acid and glycine and taurine conjugated bile salts. Integrated BA and microbiota data identified correlations with several bacterial families and BA.ConclusionThe BA/microbiota axis is still a novel area with minimal observational data in surgery. Further mechanistic research is necessary to further explore this and identify its role in improving perioperative outcomes.

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“…The colonic microbial communities have a well‐established role in metabolizing BAs to facilitate reabsorption [19]. Two studies (Boutte et al.…”

Section: Resultsmentioning

confidence: 99%

“…The colonic microbial communities have a well-established role in metabolizing BAs to facilitate reabsorption [19]. were unchanged, there was noted to be a decreased ratio of conjugated/unconjugated BAs and primary/secondary BAs.…”

Section: Microbiota and Ba Changes In Patients With An Ileal Resectio...mentioning

confidence: 99%

Influence of the bile acid/microbiota axis in ileal surgery: a systematic review

Senanayake,

Makanyengo,

Hoedt

et al. 2024

Colorectal Disease

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“…In addition to this, changes in bile acid may be the link between diet, the microbiota, and leaky gut, all of which may be factors that contribute to the development of FD ( Keely and Talley, 2020 ). For example, excess dietary fats are likely to increase intestinal permeability through a variety of mechanistic pathways, including the modification of tight junction expression and distribution, the promotion of the transition to barrier-disruptive hydrophobic bile acids, and the induction of oxidative stress and apoptosis in enterocytes ( Duncanson et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Zhang

et al. 2023

Front. Neurosci.

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ObjectivesThis study aims to perform a bibliometric analysis of functional dyspepsia (FD), which includes visualizing bibliographic information, in order to identify prevailing study themes, topics of interest, contributing journals, countries, institutions, and authors as well as co-citation patterns.MethodsThe Web of Science™ Core Collection Database was used to retrieve all peer-reviewed scientific publications related to FD research. The validated search terms were entered into the “title” and “author keywords” fields, and the results were sorted by publication year from 2006 to 2022. There were no restrictions on language. On 12 February 2023, a manual export of the complete metadata for each original publication and review article was performed. CiteSpace was used to reveal co-authorship, publication, and co-citation patterns to find prominent authors, organizations, countries, and journals in FD research as well as to identify author keywords with strong citation bursts, which could indicate an emerging research area. VOSviewer was used to build the co-occurrence indicator (co-word) to identify the main author keywords on which previous studies focused and to induce clustered scientific landscape for two consecutive periods to identify intriguing areas for future research.ResultsA search of the database retrieved 2,957 documents. There was a wave-like pattern in the number of publications until 2017, after which there was a spike in publication volume. The USA, China, and Japan provided the majority of contributions. In terms of institution, Mayo Clin, Univ Newcastle, and Katholieke Univ Leuven were found to be the prolific institutions. Additionally, the results indicate that eastern Asian researchers contributed significantly to the global knowledge of literature that led other countries; however, Canada, the USA, Australia, England, and Germany were found to have the highest degree of betweenness centrality. Nicholas J. Talley, Jan Tack, Gerald Holtmann, Michael Camilleri, Ken Haruma, and Paul Moayyedi occupied the top positions based on productivity and centrality indicators. Six thematic clusters emerged (Helicobacter pylori infection; pathophysiological mechanisms of FD; extraintestinal co-morbidities and overlap syndromes associated with FD; herbal medicine in FD; diabetic gastroparesis; and dietary factors in FD). “Acupuncture,” “duodenal eosinophilia,” “gut microbiota,” and others were among the author keywords with rising prevalence.ConclusionIn FD research, eastern Asian countries have established themselves as major contributors with the highest publishing productivity; however, research has primarily been driven by North America, Europe, and Australia, where cooperation is generally more active and highly influential scientific results are produced. Our analysis suggests that increased investments, training of human resources, improved infrastructures, and expanded collaborations are essential to improving the quality of FD research in Asia. The emerging author keyword analysis suggests that eosinophil-mast cell axis, gut microbiota, mental disorders, and acupuncture are the key areas that attract researchers’ attention as future research boulevards. There is a highly skewed distribution of research output across Asia, with most focus on complementary and alternative medicine (CAM) coming from Chinese, Japanese, and South Korean centers. However, CAM remains an underexplored area of research in the context of FD, and it deserves greater research efforts in order to obtain quality scientific evidence. Furthermore, we propose that the research framework of CAM should not be limited to dysmotility; rather, it could be interpreted within a more holistic context that includes the brain-gut-microbiota axis, as well as novel concepts such as duodenitis, increased mucosal permeability, and infiltration and activation of eosinophils and mast cells, among others. Overall, we provided bibliometrics-based overviews of relevant literature to researchers from different backgrounds and healthcare professionals to provide an in-depth overview of major trends in FD research.

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“…2016), in situations of BA excess, and this may explain why this species is commonly reported as decreased in the FGID microbiota. This hypothesis suggests the selection of a distinct microbial profile lacking BA sensitive species, in conjunction with an altered BA pool, may directly influence the epithelial barrier integrity in FGIDs (Keely & Talley, 2020). As such, BA metabolism may contribute to altered homeostatic balance in FGID patients, leading to increased barrier permeability and increased interactions between luminal antigens and the immune system.…”

Section: Barrier Disruption In Fgidsmentioning

confidence: 99%

Physiological mechanisms of unexplained (functional) gastrointestinal disorders

Burns

Hoedt

Walker

et al. 2021

The Journal of Physiology

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Functional gastrointestinal disorders (FGIDs) encompass a range of complex conditions with similar clinical characteristics and no overt pathology. Recent recognition of sub‐clinical pathologies in FGIDs, in conjunction with physiological and biochemical abnormalities including increased intestinal permeability, microbial profile alterations, differences in metabolites and extra‐intestinal manifestations of disease, call into question the designation of these conditions as ‘functional’. This is despite significant heterogeneity in both symptom profile and specifics of reported physiological abnormalities hampering efforts to determine defined mechanisms that drive onset and chronicity of symptoms. Instead, the literature demonstrates these conditions are disorders of homeostatic imbalance, with disruptions in both host and microbial function and metabolism. This imbalance is also associated with extraintestinal abnormalities including psychological comorbidities and fatigue that may be a consequence of gastrointestinal disruption. Given the exploitation of such abnormalities will be crucial for improved therapeutic selection, an enhanced understanding of the relationship between alterations in function of the gastrointestinal tract and the response of the immune system is of interest in identifying mechanisms that drive FGID onset and chronicity. Considerations for future research should include the role of sex hormones in regulating physiological functions and treatment responses in patients, as well as the importance of high‐level phenotyping of clinical, immune, microbial and physiological parameters in study cohorts. There is opportunity to examine the functional contribution of the microbiota and associated metabolites as a source of mechanistic insight and targets for therapeutic modulation. image

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Duodenal bile acids as determinants of intestinal mucosal homeostasis and disease

Cited by 9 publications

References 39 publications

Influence of the bile acid/microbiota axis in ileal surgery: a systematic review

Influence of the bile acid/microbiota axis in ileal surgery: a systematic review

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Physiological mechanisms of unexplained (functional) gastrointestinal disorders

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