Duodenal lymphocytosis in functional dyspepsia

Capannolo, Annalisa; Necozione, Stefano; Gabrieli, Dolores; Ciccone, Fabiana; Sollima, Laura; Melchiorri, Loredana; Frieri, Giuseppe

doi:10.1016/j.ajg.2019.05.006

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Microscopic enteropathy with an increased number of intestinal IELs can be associated with IDA. The increase in IELs, in addition to being a characteristic histological feature of CD, has been reported in various other disorders such as H. pylori infection, Giardia infection, IgA deficiency, hypogammaglobulinemia, autoimmune enteropathy, common variable immune deficiency, eosinophilic gastroenteritis, collagenous sprue, and Crohn's disease [87,88].…”

Section: Other Causes Of Iron Deficiency Anemia In Celiac Patientsmentioning

confidence: 87%

Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet

et al. 2020

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Celiac disease (CD) is an autoimmune disorder characterized by intolerance to dietary gluten in genetically predisposed subjects. Iron deficiency anemia (IDA) is a common sign in CD, being the only abnormality in approximately 40% of celiac patients. A multifactorial etiology leads to IDA in CD. The two main causes are the villous atrophy of the mucosa at the site of iron absorption (the duodenum) and the resulting inflammation, which triggers the mechanism that leads to the anemia of chronic disease. Until now, it has been unclear why some patients with CD continue to have IDA despite a careful gluten-free diet (GFD) and the normalization of villous atrophy. Furthermore, some celiac patients are refractory to oral iron supplementation despite the healing of the mucosa, and they thus require periodic intravenous iron administration. The Marsh classification evaluates the degree of inflammation and villous atrophy, but it does not assess the possible persistence of ultrastructural and molecular alterations in enterocytes. The latter was found in CD in remission after adopting a GFD and could be responsible for the persistently reduced absorption of iron and IDA. Even in non-celiac gluten sensitivity, anemia is present in 18.5–22% of patients and appears to be related to ultrastructural and molecular alterations in intestinal microvilli. It is possible that a genetic component may also play a role in IDA. In this review, we evaluate and discuss the main mechanisms of IDA in CD and the possible causes of its persistence after adopting a GFD, as well as their therapeutic implications.

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Section: Other Causes Of Iron Deficiency Anemia In Celiac Patientsmentioning

confidence: 87%

Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet

et al. 2020

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Functional Dyspepsia and Food: Immune Overlap with Food Sensitivity Disorders

Pryor

Burns

Duncanson

et al. 2020

Curr Gastroenterol Rep

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Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

Wang

Fang

2021

J Neurogastroenterol Motil

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Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders (FGIDs) and account for a large proportion of consulting patients. These 2 disorders overlap with each other frequently. The pathogenesis of IBS or FD is complicated and multi-factors related, in which infectious or non-infectious inflammation and local or systemic immune response play significant roles. There are few studies focusing on the mechanism of inflammation in patients with overlap syndrome of irritable bowel syndrome and functional dyspepsia (IBS-FD). This review focuses on current advances about the role of inflammation in the pathogenesis of IBS and FD and the possible mechanism of inflammation in IBS-FD.

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Duodenal lymphocytosis in functional dyspepsia

Cited by 3 publications

References 30 publications

Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet

Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet

Functional Dyspepsia and Food: Immune Overlap with Food Sensitivity Disorders

Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

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