Duodenal metastasis from lung adenocarcinoma: A rare cause of melena

Alsaeed, Eyad; Tunio, Mutahir A.; Alsayari, Khalid; Al-Dandan, Sadeq; Riaz, Khalid

doi:10.1016/j.ijscr.2015.06.019

Cited by 21 publications

(36 citation statements)

References 10 publications

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“…However, previous research reports indicate that the locations of metastatic adenocarcinoma of lung origin in the duodenum were the second portion, 5,11 the third portion, 6 and the fourth portion of duodenum. 3,9,12 Besides, those patients were found in the opposite site of papilla of Vater, 4 in the duodenal bulb, 7 and bulging mucosa on the minor papilla of the duodenum abnormalities. 10 Early duodenal adenocarcinoma symptoms are typically vague.…”

Section: Discussionmentioning

confidence: 93%

“…Among small bowel metastasis, the jejunum is the most frequent site of involvement (50.9%), followed by the ileum (33.3%), and the duodenum (15.8%). 9 The vast majority of duodenum metastatic lung adenocarcinoma patients present with vague chief complaints such as weight loss, 3,4,9 melena, 3,5,7,9 anorexia, 3,4,6,9 epigastric pain or discomfort, 4,9,10 lethargy, 4,9 abdominal fullness, 6 altered bowel habit, 3 indigestion, 10 shortness of breath, 5 dyspnea on exertion, 3 weakness, 3,5 anemia, 7 fever, 6 cough, 3 blood stained sputum, 3 fatigue, 3 or no clinical symptoms. 11 Compared with previous case reports, the patient complaining of gastroesophageal reflux disease is rarely encountered in this report.…”

Section: Discussionmentioning

confidence: 99%

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Duodenum metastatic adenocarcinoma of lung origin: A case report

Tsai

Chen

Tung

2020

Adv in Digestive Medicine

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Duodenal metastases from lung adenocarcinoma are extremely uncommon, and rarely produce symptoms. We report a case of duodenal metastasis from primary lung adenocarcinoma presented with history of gastroesophageal reflux disease, superficial gastritis, and chemotherapy‐related grade I fatigue. Tumor cells showed immunopositivity for cytokeratin‐7 (CK7), thyroid transcription factor 1, and immunonegativity for CK20, CDX2, and synaptophysin, supporting the diagnosis of metastatic adenocarcinoma of the lung origin.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Duodenum metastatic adenocarcinoma of lung origin: A case report

Tsai

Chen

Tung

2020

Adv in Digestive Medicine

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“…On endoscopy, most metastatic lesions present as "volcano-like tumors" or submucosal tumors with bridging folds and superficial ulcerations [20,21]. Moreover, capsule endoscopy has been shown to be more effective in detecting small bowel abnormalities when compared to push enteroscopy and is usually indicated for cases of obscure GI bleeds [22]. The literature also has evidence of technetium-labelled red blood cell scans being used to successfully locate the source of bleeding from a primary lung cancer metastasis to the small bowel [10].…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

Ahmed

Nasir

Donna

et al. 2020

Case Rep Gastroenterol

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Lung cancer is a common malignancy which is frequently found to metastasize to distant sites including bone, liver, and adrenal glands. There are rare reports of metastases to the gastrointestinal (GI) tract, with the duodenum being the most uncommon. We present a rare case of a poorly differentiated lung carcinoma metastasizing to the duodenum. This case enhances the medical literature as it provides additional distinct features to the clinical and histological presentation of metastatic lung carcinoma to the GI tract. A 61-year-old male with a history of poorly differentiated lung carcinoma presented with worsening dizziness, fatigue, and early satiety. He had extensive workup done in the past for hemoptysis including a computerized tomography scan of the chest which showed a new lobulated, apical lesion and hilar Case Ahmed et al.: Poorly Differentiated Lung Carcinoma Metastasis to the Duodenum 187lymphadenopathy. He ultimately had a transthoracic fine-needle aspiration (FNA) of the mass and was later diagnosed with poorly differentiated lung carcinoma. On examination, the patient was noted to be pale, tachycardic, and hypotensive. The patient was noted to have an acute drop in his hemoglobin requiring fluid resuscitation, multiple blood transfusions, and evaluation with an esophagogastroduodenoscopy. He was found to have an oozing ulcer in the third portion of the duodenum whose biopsies showed poorly differentiated carcinoma with areas of neuroendocrine differentiation, similar to his lung biopsy results, which was consistent with metastatic lung carcinoma.

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“…Distant metastases from lung cancer are usually found in the lung, bone, brain, liver, and adrenal gland; however, metastases in duodenum and pancreas are very rare (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). We report herein our experience with case of duodenal and pancreas metastases from lung adenocarcinoma.…”

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confidence: 99%

Duodenal and pancreas metastasis from lung cancer

Tamura¹,

Ohara²,

Kagohashi³

et al. 2017

Tuberk Toraks

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Distant metastases from lung cancer are usually found in the lung, bone, brain, liver, and adrenal gland; however, metastases in duodenum and pancreas are very rare (1-10). We report herein our experience with case of duodenal and pancreas metastases from lung adenocarcinoma.A 56-year-old man was referred to our hospital due to an ill-defined mass, which was diagnosed as having lung adenocarcinoma pathologically, in the left lower lobe of the lung with ipsilateral mediastinal lymph nodes (Figure 1). The patient was treated with platinum-based chemotherapy for 5 months. The patient was readmitted with the two weeks history of epigastric pain. He also complained of anorexia, lethargy, and weight loss of 4 kilograms over past four months. Epigastric pain was not dull in nature, aggravated by food in take, and it had increased in intensity over two weeks, for which he was taking oxycodone/acetaminophen, but minimal pain relief. The patient had 10-year history of systemic lupus erythematosus, which has been treated with prednisolone. He was ex-smoker with one pack a day for 20 years. On physical examination, he was found in fair general condition, but his vitals were stable.On abdominal examination, there was mild epigastric tenderness without any rigidity, guarding, orrebound tenderness. The rest of systemic examination was unremarkable. Complete blood count (CBC) showed hemoglobin 12.0 gm/dL, white blood cells (WBC) 8200/microL; and platelets 336.000/microL. Liver and renal function tests were within normal limits. Fecal occult blood (FOB) test was found negative. Upper gastrointestinal endoscopy revealed a tumorous lesion at the opposite site of papilla of Vater (Figure 2). Pathological specimen from the duodenal lesion showed adenocarcinoma and immuno histochemical staining for thyroid transcription factor-1 positive cells ( Figure 3A: Hematoxylin-Eosin staining, Figure 3B: thyroid transcription factor-1: TTF-1). These findings strongly supported the diagnosis of metastatic adenocarcinoma of the lung origin. Computed tomography (CT) of abdomen showed ill-defined mass measuring 3.2×3.0 cm in Duodenal and pancreas metastasis from lung cancer

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Duodenal metastasis from lung adenocarcinoma: A rare cause of melena

Abstract: HighlightsDuodenal metastasis.Melena and microcytic anemia.Lung carcinoma.

Cited by 21 publications

References 10 publications

Duodenum metastatic adenocarcinoma of lung origin: A case report

Duodenum metastatic adenocarcinoma of lung origin: A case report

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review

Duodenal and pancreas metastasis from lung cancer

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