Duodenal microbiota and weight-loss following sleeve gastrectomy and Roux-en-Y gastric bypass – a pilot study

Abstract

Background Bariatric surgery is the most effective method of morbid obesity treatment. Microbiota has many functions in human body and many of them are still unknown. The aim of this study was to establish if the composition of duodenal microbiota influence success rate of bariatric surgery. Methods It was a prospective cohort study. The data concerning demographics and comorbidities was collected perioperatively. The duodenal biopsies were collected prior to surgery with the gastroscope. Then DNA analysis was conducted. The data connected to the operation outcomes was gathered after 6 and 12 months after surgery. Results The group of 32 patients was included. Two groups (successful – group 1 and unsuccessful – group 0) based on percentage excess weight loss after 6 months were created. The Total Actual Abundance was higher in group 0. In group 0 there was a significantly higher amount of Roseburia and Arthrobacter (p = 0.024, p = 0.027, respectively). Genus LDA effect size analysis showed Prevotella, Megasphaera and Pseudorhodobacter in group 1 to be significant. Whereas Roseburia and Arthrobacter were significant in group 0. Conclusions Duodenal microbiota composition may be a prognostic factor for the success of the bariatric surgery but further research on the larger group is needed.