Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

Dong, Minyue; Sonoda, Yoshimi; Kawamoto, Masahiko; Konomi, Hiroyuki; Kobayashi, Kiroku; Yamaguchi, Koji; Tanaka, Masao

doi:10.1007/s00535-004-1557-9

Cited by 11 publications

(14 citation statements)

References 29 publications

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“…The lack of responsiveness to CCK‐8 may be attributed to many factors, including prolonged fasting or the presence of the tube and inflated balloon in the duodenum for a prolonged period of time. It is well documented in animals that the duodenum is important in maintaining sphincter of Oddi response to CCK [8]. Thus, it is possible that the pressure exerted by the inflated balloon on the duodenal walls may have modified the response to CCK‐8.…”

Section: Discussionmentioning

confidence: 99%

Determination of the biliary excretion of piperacillin in humans using a novel method

Ghibellini¹,

Vasist²,

Hill³

et al. 2006

Brit J Clinical Pharma

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AimTo evaluate the applicability of a novel method to determine the biliary excretion of piperacillin. MethodsHealthy volunteers were administered piperacillin i.v. Duodenal aspirates were collected via a custom-made oroenteric catheter; blood and urine also were collected. Gallbladder ejection fraction (EF) was determined by gamma scintig raphy and pharmacokinetic parameters were calculated using noncompartmental analysis. ResultsThe fraction of the piperacillin dose excreted unchanged into bile was 1.1 ± 0.3% (biliary clearance corrected for EF was 0.032 ± 0.008 ml min − 1 kg − 1 ). ConclusionsThis methodology can be used to determine reliably the biliary clearance of drugs that are excreted only marginally into bile. Normalization of biliary clearance for EF significantly reduces intersubject variability of this parameter.

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Section: Discussionmentioning

confidence: 99%

Determination of the biliary excretion of piperacillin in humans using a novel method

Ghibellini¹,

Vasist²,

Hill³

et al. 2006

Brit J Clinical Pharma

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“…Thus, we were able to compare the effects of various reagents in the same animals. In this context, four to six dogs have been used in recent studies from our institution (Hayashi et al 2010;Sato et al 2010a) and other institutions (Dong et al 2005;Morita et al 2012;Yanai et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Intragastric Dai-Kenchu-To, a Japanese Herbal Medicine, Stimulates Colonic Motility via Transient Receptor Potential Cation Channel Subfamily V Member 1 in Dogs

Kikuchi

Shibata

Imoto

et al. 2013

Tohoku J. Exp. Med.

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Japanese herbal medicine, also known as Kampo, is used for various diseases in Japan. One of those medicines, Dai-Kenchu-To (DKT), is considered clinically effective for adhesive bowel obstruction and chronic constipation. Although scientific evidence of DKT to improve adhesive bowel obstruction was shown in several previous reports, mechanism of DKT to improve constipation remains unknown. Our aim was to study the effect of intragastric DKT on colonic motility and defecation, and the involvement of various receptors in DKT-induced colonic contractions. Five beagle dogs were instructed with serosal strain-gauge force transducers to measure circular muscle activity at the proximal, middle, and distal colon. Dogs are suitable for a present study to administer the drugs repeatedly to the same individual and look at its effect on colonic motility. We studied the effects of DKT (2.5 or 5 g) administered into the stomach on colonic motility. Muscarinic receptor antagonist atropine, nicotinic receptor antagonist hexamthonium, or 5-hydroxytryptamine-3 receptor antagonist ondansetron was injected intravenously 10 min before DKT administration. Capsazepine, an antagonist to transient receptor potential cation channel subfamily V member 1 (TRPV1), was administered into the stomach 5 min before DKT administration. Intragastric DKT (2.5 or 5 g) induced colonic contractions within 10 min after administration but did not induce defecation. Pretreatment with atropine, hexamthonium, ondansetron, or capsazepine inhibited DKT-induced colonic contractions. These results indicate that orally administered DKT stimulates colonic motility via TRPV1, muscarinic, nicotinic, and 5-hydroxytryptamine-3 receptors, thereby providing scientific support for the efficacy of oral DKT in chronic constipation.

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“…The role of the duodenum in the SO response to CCK was recently investigated in a conscious dog model [17]. Disruption of the duodenal-SO neural connections by surgical translocation of the SO from the duodenum to the jejunum modified the SO response to intravenous CCK.…”

Section: Vasoactive Intestinal Peptidementioning

confidence: 99%

Neurohormonal regulation of the sphincter of oddi

Woods

Saccone

2007

Curr Gastroenterol Rep

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The control of sphincter of Oddi (SO) motor activity is complex and involves interactions between the SO smooth muscle with nerves, bioactive agents, and presumably interstitial cells of Cajal. Disturbances in SO motility are known to be related to painful clinical conditions, such as SO dysfunction and acute pancreatitis. Understanding normal SO motility and comparing this to disturbed SO motility patterns may identify mechanisms that could be targeted for future pharmacologic intervention. The effect on SO motility of recently identified neurotransmitters/neuropeptides, such as purines and orexins, is currently being determined. Furthermore, because the control of SO motility is complex, investigations with known bioactive agents, such as cholecystokinin and nitric oxide, are continuing. This review summarizes research investigating SO motility and function performed in 2005 and 2006.

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Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs

Cited by 11 publications

References 29 publications

Determination of the biliary excretion of piperacillin in humans using a novel method

Determination of the biliary excretion of piperacillin in humans using a novel method

Intragastric Dai-Kenchu-To, a Japanese Herbal Medicine, Stimulates Colonic Motility via Transient Receptor Potential Cation Channel Subfamily V Member 1 in Dogs

Neurohormonal regulation of the sphincter of oddi

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