DUOX1‐mediated hydrogen peroxide release regulates sodium transport in H441 bronchiolar epithelial cells

Abstract

Our observations suggest that tonic production of H O by DUOX1 participates in maintaining the level of vectorial sodium transport by lung epithelial cells. Moreover, the system appears to be well tuned as it would allow H O -dependent innate immunity without inducing airway/alveolar sodium and fluid hyperabsorption.

Polyamines, metabolites and metabolomics

“…On the other hand, polyamines also serve as substrates for oxidation reactions that produce H 2 O 2 both, intra‐ and extracellularly. Even though small amounts of H 2 O 2 are required for cellular signalling, 11 elevated levels may cause different pathologies including vascular dysfunction and cellular damage after ischaemia‐reperfusion injury 12,13 . Another reason underlining the importance of polyamines for survival of eukaryotic cells is that spermidine plays a unique role in the initiation of translation.…”