“…Also, there is a possible bacterial infection of the scarred renal tissues and functional tubule abnormalities in conjunction with the compromised immunity, leading to abscess formation [26,27] Table(3) presented the lungs CT manifestation in SCA : pleural effusion, pneumonia ,atelectasis, ground glass nodules ,consolidation ,fibrosis lung abscess which was found in different ages as well; at all types of SCD including Hb SS ,Hb SC ,Hb SB 0-thalassemia ,Hb SB+ thalassemia that are presented in table ( 8) Similar studies have mentioned that the acute chest syndrome is one of the most common causes of hospitalization and even death of SCA patients, pulmonary vascular obstruction. [28]and pleural effusion may also be seen, [29,30] Patients with SCA may develop obstructive or restrictive lung diseases, when there is a progressive decline in the pulmonary functions .This may be explained by established fibrotic lung changes from repeated episodes of pulmonary infective and vaso-occlusive events. High resolution CT scan (HRCT) shows these interstitial changes, that are of reticular or reticulonodular pattern and may be associated with traction bronchiectasis [31] …”