Duplex imaging of residual venous obstruction to guide duration of therapy for lower extremity deep venous thrombosis

Stephenson, Elliot; Liem, Timothy K.

doi:10.1016/j.jvsv.2014.08.003

Cited by 12 publications

(19 citation statements)

References 26 publications

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“…Stephenson et al 1 published a recent meta-analysis (included six articles) that showed that RVO is a mild risk factor for VTE recurrence. 1 A prospective cohort study performed by Cosmi et al 1 showed that the RVOþ group had a higher VTE recurrence rate, but that was not statistically significant. Poli et al 1 performed a prospective cohort study that showed similar VTE recurrence rate between RVOþ and RVOÀ groups.…”

Section: Discussionmentioning

confidence: 96%

“…There are many definitions of RVO. 1 According to Prandoni et al, at maximal compression, if the compressed vein's diameter was >2 mm when a single test was performed or if the compressed vein's diameter was >3 mm in two consecutive compression measurements, RVO was considered present. 1 Siragusa et al 1 defined the presence of RVO as a compressed vein's diameter >40% of the noncompressed vein's diameter.…”

Section: Discussionmentioning

confidence: 99%

“…1 According to Prandoni et al, at maximal compression, if the compressed vein's diameter was >2 mm when a single test was performed or if the compressed vein's diameter was >3 mm in two consecutive compression measurements, RVO was considered present. 1 Siragusa et al 1 defined the presence of RVO as a compressed vein's diameter >40% of the noncompressed vein's diameter. Le Gal et al 1 came out with the third definition which classified RVO degree into five categories: mild RVO with normal compression ultrasound appearance, minimal wall thickening (5% or less of maximal vein diameter), partial resolution (40% or more of the vein's diameter was compressible), minimal resolution (less than 40% of the vein being compressible), and stable/worsened thrombus.…”

Section: Discussionmentioning

confidence: 99%

“…Surveillance CUS after initial diagnosis of lower limb DVT can assess the thrombus progression in patients who have been unable to receive anticoagulation treatment. 1 It also Different studies assessing the role of RVO as a predictor of VTE recurrence has generated different results. Stephenson et al 1 published a recent meta-analysis (included six articles) that showed that RVO is a mild risk factor for VTE recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The technique which was used was similar to the Prandoni technique. 1 On the compressibility scan, a compressible vein was considered normal. If the vein could only be compressed partially, it suggested the presence of thrombus.…”

mentioning

confidence: 99%

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Preliminary Investigations Showing Venous Thromboembolism Recurrence in Patients with Residual Venous Obstruction in Singaporean Population

Sule

Chong

et al. 2017

Int J Angiol

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This study aims to determine the association of residual venous obstruction (RVO) with recurrent venous thromboembolism (VTE). A retrospective cohort study was conducted determining if RVO on ultrasonography is associated with recurrent VTE in a Singaporean population. The subjects were identified from the Vascular Diagnostic Laboratory patients' record of Tan Tock Seng Hospital (TTSH), Singapore between 2008 and 2013. All the patients included had RVO after 3 months of anticoagulation. Data such as age, gender, race, thrombus location, etiology, history of malignancy, thrombophilia screen, treatment duration, and follow-up were recorded for analysis. Statistical analysis was performed using Stata/SE 13.1 (StataCorp LLC). The study was approved by the National Healthcare Group Domain Specific Review Board (DSRB), Singapore. Out of the 34 patients who had RVO, 6 (17.6%) developed VTE recurrence. Patients were treated with anticoagulation for a mean time of 24.5 months. The mean follow-up time for VTE recurrence was 25.4 months. Out of the six patients who had VTE recurrence, one had common iliac vein involvement, four had superficial femoral vein and common femoral vein involvement, zero had popliteal vein involvement, and one had calf veins involvement. There was a significant association between thrombophilia ( = 0.0195) and malignancy ( = 0.020) at inclusion with the risk of recurrent VTE. The presence of RVO after 3 months of anticoagulation is likely to increase the risk of VTE recurrence. Larger studies with RVO are needed to evaluate if there is an increased risk of VTE recurrence in the Asian population.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%