Duplicate Type and Screen Testing: Waste in the Clinical Laboratory

Compton, Margaret; Szklarski, Penny C.; Booth, Garrett S.

doi:10.5858/arpa.2016-0629-oa

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…The range of HHb concentrations is chosen to investigate sensitivity of the MIP in diluted blood samples, which would enable decreasing the sample volume up to a factor 1000, thus strongly reducing medical waste in clinical applications. [76,[103][104][105][106][107] Figure 3b shows the calibration curve of the MIP-and NIP-coated PSiO 2 scaffolds. Two linear regions are evident for the MIP-based sensor, namely, a higher-sensitivity region between 0.1 and 1 mg mL −1 and a lower-sensitivity region between 1 and 8 mg mL −1 .…”

Section: Resultsmentioning

confidence: 99%

Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Mazzotta

Giulio

Mariani

et al. 2023

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Molecularly imprinted polymers (MIPs) have recently emerged as robust and versatile artificial receptors. MIP synthesis is carried out in liquid phase and optimized on planar surfaces. Application of MIPs to nanostructured materials is challenging due to diffusion‐limited transport of monomers within the nanomaterial recesses, especially when the aspect ratio is >10. Here, the room temperature vapor‐phase synthesis of MIPs in nanostructured materials is reported. The vapor phase synthesis leverages a >1000‐fold increase in the diffusion coefficient of monomers in vapor phase, compared to liquid phase, to relax diffusion‐limited transport and enable the controlled synthesis of MIPs also in nanostructures with high aspect ratio. As proof‐of‐concept application, pyrrole is used as the functional monomer thanks to its large exploitation in MIP preparation; nanostructured porous silicon oxide (PSiO2) is chosen to assess the vapor‐phase deposition of PPy‐based MIP in nanostructures with aspect ratio >100; human hemoglobin (HHb) is selected as the target molecule for the preparation of a MIP‐based PSiO2 optical sensor. High sensitivity and selectivity, low detection limit, high stability and reusability are achieved in label‐free optical detection of HHb, also in human plasma and artificial serum. The proposed vapor‐phase synthesis of MIPs is immediately transferable to other nanomaterials, transducers, and proteins.

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Section: Resultsmentioning

confidence: 99%

Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Mazzotta

Giulio

Mariani

et al. 2023

Small

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“…We hypothesized that transplant physicians may have a practice habit of screening for fungal infections among transplant patients that they extend to nontransplant patients as a possible explanation for why they were more likely to order avoidable tests in these lower-risk patients. Inappropriate test ordering by specific clinical services has been reported previously; for example, a single-center retrospective study from Vanderbilt University Medical Center showed that duplicate type and screen tests for nontransplant patients were more common among adult services than pediatric services [ 16 ]. Additionally, several departments, especially where they care for transplant recipients, used NCBFAs in the routine order sets on admission or when working up for fever or increased inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors for Inappropriate Use of Non-Culture-Based Fungal Assays: Implication for Diagnostic Stewardship

Ito

Okamoto

Yamamoto

et al. 2021

Open Forum Infectious Diseases

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Background Non-culture-based fungal assays (NCBFAs) have been used increasingly to help diagnose invasive fungal diseases. However, little is known about inappropriate use of NCBFAs. We aimed to investigate inappropriate use of NCBFAs in a tertiary academic hospital. Methods This retrospective cohort study included patients who underwent testing with beta-D glucan (BDG) between Jan and Mar 2018, or galactomannan antigen (GMA) or cryptococcal antigen (CRAG) between Jan and Jun 2018. Testing was deemed appropriate if the clinical presentation was compatible with a fungal infection and there was a predisposing host factor at the time of ordering. We compared patients with appropriate and inappropriate use of NCBFAs using the multivariate logistic regression analysis. Results 470 patients (BDG, 394; GMA, 138; CRAG, 164) met inclusion criteria and were evaluated. About 80% of NCBFAs were deemed inappropriate. Ordering by transplant medicine physicians, repetitions of the test, the absence of predisposing factors for fungal infections, and the absence of recommendations from infectious diseases consultants were associated with an increased risk of inappropriate NCBFA use. Conclusions We found a large proportion of NCBFAs were deemed inappropriate. There is an opportunity for diagnostic stewardship to reduce avoidable fungal testing among patients at low risk for fungal infection.

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Reducing Overuse of 3-Day Repeat Type and Screen Testing across an 11-Hospital Safety Net System

et al. 2023

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Duplicate Type and Screen Testing: Waste in the Clinical Laboratory

Abstract: - Our study demonstrates that inappropriate TS ordering is costly, both financially and clinically. By evaluating the percentage of inappropriate TS tests by clinical services, we have identified services that may benefit from additional education and technologic intervention.

Cited by 7 publications

References 21 publications

Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Incidence and Risk Factors for Inappropriate Use of Non-Culture-Based Fungal Assays: Implication for Diagnostic Stewardship

Reducing Overuse of 3-Day Repeat Type and Screen Testing across an 11-Hospital Safety Net System

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