Duplicated Gene Evolution of the Primate Alcohol Dehydrogenase Family

Oota, Hiroki; Kídd, Kenneth K.

doi:10.1007/978-4-431-54011-3_9

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Frugivory is common across animals, so we might ask whether diverse fruit-eating species share molecular adaptations to alcohol metabolism. Across species, alcohol is first metabolized by alcohol dehydrogenase (ADH), producing a toxic intermediate, acetaldehyde, which is in turn converted to harmless acetate by the enzyme aldehyde dehydrogenase (ALDH) (for a more complete review of alcohol metabolic genes, see Oota et al 39 ). Interestingly, in D. melanogaster , increased alcohol metabolism correlates with ethanol content of species-specific food niches, 40 and intra-specific variation in alcohol sensitivity correlates with ADH activity toward alcohol in D. melanogaster .…”

Section: Evidence Of Molecular Adaptations To Alcohol Metabolism Amon...mentioning

confidence: 99%

The Promise of an Evolutionary Perspective of Alcohol Consumption

2023

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The urgent need for medical treatments of alcohol use disorders has motivated the search for novel molecular targets of alcohol response. Most studies exploit the strengths of lab animals without considering how these and other species may have adapted to respond to alcohol in an ecological context. Here, we provide an evolutionary perspective on the molecular and genetic underpinnings of alcohol consumption by reviewing evidence that alcohol metabolic enzymes have undergone adaptive evolution at 2 evolutionary junctures: first, to enable alcohol consumption accompanying the advent of a frugivorous diet in a primate ancestor, and second, to decrease the likelihood of excessive alcohol consumption concurrent with the spread of agriculture and fermentation in East Asia. By similarly considering how diverse vertebrate and invertebrate species have undergone natural selection for alcohol responses, novel conserved molecular targets of alcohol are likely be discovered that may represent promising therapeutic targets.

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Section: Evidence Of Molecular Adaptations To Alcohol Metabolism Amon...mentioning

confidence: 99%

The Promise of an Evolutionary Perspective of Alcohol Consumption

2023

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show abstract

“…Frugivory is common across animals, so we might ask whether diverse fruit-eating species share molecular adaptations to alcohol metabolism. Across species, alcohol is first metabolized by alcohol dehydrogenase (ADH), producing a toxic intermediate, acetaldehyde, which is in turn converted to harmless acetate by the enzyme aldehyde dehydrogenase (ALDH) (for a more complete review of alcohol metabolic genes, see Oota et al 33 ). Interestingly, in the fruit fly (Drosophila melanogaster), increased alcohol metabolism correlates with ethanol content of species-specific food niches 34 , and intra-specific variation in alcohol sensitivity correlates with ADH activity towards alcohol in D. melanogaster 35 .…”

Section: Evidence Of Molecular Adaptations To Alcohol Metabolism Amon...mentioning

confidence: 99%

The promise of an evolutionary perspective of alcohol consumption

Hofmann¹,

Clites²,

Pierce³

2022

Preprint

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The urgent need for medical treatments of alcohol use disorders has motivated the search for novel molecular targets of alcohol response. Most studies exploit the strengths of lab animals without considering how these and other species may have adapted to respond to alcohol in an ecological context. Here, we provide an evolutionary perspective on the molecular and genetic underpinnings of alcohol consumption by reviewing evidence that alcohol metabolic enzymes have undergone adaptive evolution at two evolutionary junctures: first, to enable alcohol consumption accompanying the advent of a frugivorous diet in a primate ancestor, and second, to decrease the likelihood of excessive alcohol consumption concurrent with the spread of agriculture and fermentation in East Asia. By similarly considering how diverse vertebrate and invertebrate species have undergone natural selection for alcohol responses, novel conserved molecular targets of alcohol are likely be discovered that may represent promising therapeutic targets.

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The Natural History of Class I Primate Alcohol Dehydrogenases Includes Gene Duplication, Gene Loss, and Gene Conversion

et al. 2012

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BackgroundGene duplication is a source of molecular innovation throughout evolution. However, even with massive amounts of genome sequence data, correlating gene duplication with speciation and other events in natural history can be difficult. This is especially true in its most interesting cases, where rapid and multiple duplications are likely to reflect adaptation to rapidly changing environments and life styles. This may be so for Class I of alcohol dehydrogenases (ADH1s), where multiple duplications occurred in primate lineages in Old and New World monkeys (OWMs and NWMs) and hominoids.Methodology/Principal FindingsTo build a preferred model for the natural history of ADH1s, we determined the sequences of nine new ADH1 genes, finding for the first time multiple paralogs in various prosimians (lemurs, strepsirhines). Database mining then identified novel ADH1 paralogs in both macaque (an OWM) and marmoset (a NWM). These were used with the previously identified human paralogs to resolve controversies relating to dates of duplication and gene conversion in the ADH1 family. Central to these controversies are differences in the topologies of trees generated from exonic (coding) sequences and intronic sequences.Conclusions/SignificanceWe provide evidence that gene conversions are the primary source of difference, using molecular clock dating of duplications and analyses of microinsertions and deletions (micro-indels). The tree topology inferred from intron sequences appear to more correctly represent the natural history of ADH1s, with the ADH1 paralogs in platyrrhines (NWMs) and catarrhines (OWMs and hominoids) having arisen by duplications shortly predating the divergence of OWMs and NWMs. We also conclude that paralogs in lemurs arose independently. Finally, we identify errors in database interpretation as the source of controversies concerning gene conversion. These analyses provide a model for the natural history of ADH1s that posits four ADH1 paralogs in the ancestor of Catarrhine and Platyrrhine primates, followed by the loss of an ADH1 paralog in the human lineage.

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Duplicated Gene Evolution of the Primate Alcohol Dehydrogenase Family

Cited by 4 publications

References 52 publications

The Promise of an Evolutionary Perspective of Alcohol Consumption

The Promise of an Evolutionary Perspective of Alcohol Consumption

The promise of an evolutionary perspective of alcohol consumption

The Natural History of Class I Primate Alcohol Dehydrogenases Includes Gene Duplication, Gene Loss, and Gene Conversion

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